Search Results - "Heinrich, Victoria A."

Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma by Manni, Michelle L., Heinrich, Victoria A., Buchan, Gregory J., O’Brien, James P., Uvalle, Crystal, Cechova, Veronika, Koudelka, Adolf, Ukani, Dharti, Rawas-Qalaji, Mohamad, Oury, Tim D., Hart, Renee, Ellgass, Madeline, Mullett, Steven J., Fajt, Merritt L., Wenzel, Sally E., Holguin, Fernando, Freeman, Bruce A., Wendell, Stacy G.

“…Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung…”
Get full text

Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma by Heinrich, Victoria A, Uvalle, Crystal, Manni, Michelle L, Li, Kelvin, Mullett, Steven J, Donepudi, Sri Ramya, Clader, Jason, Fitch, Adam, Ellgass, Madeline, Cechova, Veronika, Qin, Shulin, Holguin, Fernando, Freeman, Bruce A, Methé, Barbara A, Morris, Alison, Gelhaus, Stacy L

“…Obesity and associated changes to the gut microbiome worsen airway inflammation and hyperresponsiveness in asthma. Obesogenic host-microbial metabolomes have…”
Get full text

Evolved resistance to a novel cationic peptide antibiotic requires high mutation supply by Santos-Lopez, Alfonso, Fritz, Melissa J, Lombardo, Jeffrey B, Burr, Ansen H P, Heinrich, Victoria A, Marshall, Christopher W, Cooper, Vaughn S

“…Abstract Background and Objectives A key strategy for resolving the antibiotic resistance crisis is the development of new drugs with antimicrobial properties…”
Get full text

Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria by Hurley, Katherine A, Heinrich, Victoria A, Hershfield, Jeremy R, Demons, Samandra T, Weibel, Douglas B

“…We performed a structure–activity relationship study of 2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)­amino)-2-(hydroxymethyl)­propane-1,3-diol…”
Get full text

Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase by Hurley, Katherine A, Santos, Thiago M A, Fensterwald, Molly R, Rajendran, Madhusudan, Moore, Jared T, Balmond, Edward I, Blahnik, Brice J, Faulkner, Katherine C, Foss, Marie H, Heinrich, Victoria A, Lammers, Matthew G, Moore, Lucas C, Reynolds, Gregory D, Shearn-Nance, Galen P, Stearns, Brian A, Yao, Zi W, Shaw, Jared T, Weibel, Douglas B

“…Bacterial DNA gyrase is an essential type II topoisomerase that enables cells to overcome topological barriers encountered during replication, transcription,…”
Get full text

Systemic bile acids potentiate airway hyperresponsiveness and modulate Th17 cell function in obesity-associated asthma by Manni, Michelle L, Heinrich, Victoria A, Uvalle, Crystal E, Manuel, Allison, Ellgass, Madeline R, Mullett, Steven J, Normann, Marigny C, Koziel, Corrine, Fajt, Merritt L, Wenzel, Sally E, Holguin, Fernando, Freeman, Bruce A, Wendell, Stacy L

“…Obesity-associated asthma is phenotypically characterized by low grade inflammation and resistance to standard therapies. Like many other asthma endotypes, the…”
Get full text

Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyraseThe authors declare no competing interests.The authors declare no competing financial interest.Electronic supplementary information (ESI) available: Tables, figures, bacterial strain information and compound purity data. See DOI: 10.1039/c7md00012j by Hurley, Katherine A, Santos, Thiago M. A, Fensterwald, Molly R, Rajendran, Madhusudan, Moore, Jared T, Balmond, Edward I, Blahnik, Brice J, Faulkner, Katherine C, Foss, Marie H, Heinrich, Victoria A, Lammers, Matthew G, Moore, Lucas C, Reynolds, Gregory D, Shearn-Nance, Galen P, Stearns, Brian A, Yao, Zi W, Shaw, Jared T, Weibel, Douglas B

“…Bacterial DNA gyrase is an essential type II topoisomerase that enables cells to overcome topological barriers encountered during replication, transcription,…”
Get full text

Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase† †The authors declare no competing interests. ‡ ‡The authors declare no competing financial interest. § §Electronic supplementary information (ESI) available: Tables, figures, bacterial strain information and compound purity data. See DOI: 10.1039/c7md00012j by Hurley, Katherine A., Santos, Thiago M. A., Fensterwald, Molly R., Rajendran, Madhusudan, Moore, Jared T., Balmond, Edward I., Blahnik, Brice J., Faulkner, Katherine C., Foss, Marie H., Heinrich, Victoria A., Lammers, Matthew G., Moore, Lucas C., Reynolds, Gregory D., Shearn-Nance, Galen P., Stearns, Brian A., Yao, Zi W., Shaw, Jared T., Weibel, Douglas B.

“…New gyramide antibiotics with reduced drug efflux and improved antibiotic activity against pathogenic bacteria. Bacterial DNA gyrase is an essential type II…”
Get full text