Search Results - "Heinmöller, Ernst"

Inferred Immune-Cell Activity Is an Independent Predictor of HER2-Negative Breast Cancer Prognosis and Response to Paclitaxel-Based Therapy in the GeparSepto Trial by Fasching, Peter A, Szeto, Christopher, Denkert, Carsten, Benz, Stephen, Weber, Karsten, Spilman, Patricia, Budczies, Jan, Schneeweiss, Andreas, Stickeler, Elmar, Schmatloch, Sabine, Jackisch, Christian, Karn, Thomas, Sinn, Hans Peter, Warm, Mathias, van Mackelenbergh, Marion, Rabizadeh, Shahrooz, Schem, Christian, Heinmöller, Ernst, Mueller, Volkmar, Marmé, Frederik, Soon-Shiong, Patrick, Nekljudova, Valentina, Untch, Michael, Loibl, Sibylle

“…Tumor microenvironment (TME) immune markers have been correlated with both response to neoadjuvant therapy and prognosis in patients with breast cancer. Here,…”
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Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis by Baumgart, Mario, Werther, Meike, Bockholt, Anke, Scheurer, Maria, Rüschoff, Josef, Dietmaier, Wolfgang, Ghadimi, B Michael, Heinmöller, Ernst

“…Chronic pancreatitis (CP) is a predisposing disease for pancreatic carcinoma (PC), however, precise molecular mechanisms of cancer development in the…”
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Microarray analysis reveals differential expression of benign and malignant pheochromocytoma by Waldmann, Jens, Fendrich, Volker, Holler, Julia, Buchholz, Malte, Heinmöller, Ernst, Langer, Peter, Ramaswamy, Annette, Samans, Birgit, Walz, Martin K, Rothmund, Matthias, Bartsch, Detlef K, Slater, Emily P

“…The diagnosis of a malignant pheochromocytoma (PC) can only be established by the presence of distant metastases, but a subset of apparently benign PCs develop…”
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Multiple Mutation Analyses in Single Tumor Cells with Improved Whole Genome Amplification by Dietmaier, Wolfgang, Hartmann, Arndt, Wallinger, Sabine, Heinmöller, Ernst, Kerner, Thomas, Endl, Elmar, Jauch, Karl-Walter, Hofstädter, Ferdinand, Rüschoff, Josef

“…Combining whole genome amplification (WGA) methods with novel laser-based microdissection techniques has made it possible to exploit recent progress in…”
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Molecular Analysis of Microdissected Tumors and Preneoplastic Intraductal Lesions in Pancreatic Carcinoma by Heinmöller, Ernst, Dietmaier, Wolfgang, Zirngibl, Hubert, Heinmöller, Petra, Scaringe, William, Jauch, Karl-Walter, Hofstädter, Ferdinand, Rüschoff, Josef

“…Little or no data exist concerning the inactivation of tumor suppressor genes in intraductal lesions surrounding invasive ductal pancreatic carcinomas. Using a…”
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Challenges and Pitfalls in HNPCC Screening by Microsatellite Analysis and Immunohistochemistry by Müller, Annegret, Giuffre, Giuseppe, Edmonston, Tina Bocker, Mathiak, Micaela, Roggendorf, Beate, Heinmöller, Ernst, Brodegger, Thomas, Tuccari, Giovanni, Mangold, Elisabeth, Buettner, Reinhard, Rüschoff, Josef

“…Hereditary non-polyposis colorectal cancer (HNPCC) accounts for approximately 2 to 4% of the total colorectal cancer burden. For economic reasons a diagnostic…”
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Toward Efficient Analysis of Mutations in Single Cells from Ethanol-Fixed, Paraffin-Embedded, and Immunohistochemically Stained Tissues by Heinmöller, Ernst, Liu, Qiang, Sun, Yuan, Schlake, Gudrun, Hill, Kathleen A, Weiss, Larry M, Sommer, Steve S

“…Only a few studies have demonstrated successful molecular analysis after whole genome amplification using single cells dissected from paraffin-embedded…”
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The genetic basis of sporadic pancreatic cancer by Baumgart, Mario, Heinmöller, Ernst, Horstmann, Olaf, Becker, Heinz, Ghadimi, B Michael

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Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas by Fendrich, Volker, Slater, Emily P, Heinmöller, Ernst, Ramaswamy, Annette, Celik, Ilhan, Nowak, Oxana, Chaloupka, Brunhilde, Gerdes, Berthold, Bartsch, Detlef K

“…Tissue inhibitor of metalloproteinase-3 (TIMP3) antagonizes matrix metalloproteinase activity and can suppress tumor growth, angiogenesis, invasion, and…”
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Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient - case report and review of clinicopathological features by Schildhaus, Hans-Ulrich, Lokka, Suvi, Fenner, Werner, Küster, Jens, Kühnle, Ingrid, Heinmöller, Ernst

“…Embryonal rhabdomyosarcoma of the prostate in an adult is a very rare event with only a few cases published. Diagnosis usually occurs with advanced disease…”
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Caveolin Gene Expression Predicts Clinical Outcomes for Early-Stage HER2-Negative Breast Cancer Treated with Paclitaxel-Based Chemotherapy in the GeparSepto Trial by Williams, Terence M, Schneeweiss, Andreas, Jackisch, Christian, Shen, Changxian, Weber, Karsten E, Fasching, Peter A, Denkert, Carsten, Furlanetto, Jenny, Heinmöller, Ernst, Schmatloch, Sabine, Karn, Thomas, Szeto, Christopher W, van Mackelenbergh, Marion T, Nekljudova, Valentina, Stickeler, Elmar, Soon-Shiong, Patrick, Schem, Christian, Mairinger, Thomas, Müller, Volkmar, Marme, Frederik, Untch, Michael, Loibl, Sibylle

“…Caveolin-1 and -2 (CAV1/2) dysregulation are implicated in driving cancer progression and may predict response to nab-paclitaxel. We explored the prognostic…”
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Abstract PD5-08: Tumor immune-cell activity assessed by RNAseq is an independent predictor of therapy response and prognosis after neoadjuvant chemotherapy in HER2 negative breast cancer patients - An analysis of the GeparSepto trial by Fasching, Peter A, Denkert, Carsten, Benz, Stephen, Weber, Karsten E, Szeto, Christopher, Budczies, Jan, Schneeweiss, Andreas, Stickeler, Elmar, Schmatloch, Sabine, Jackisch, Christian, Karn, Thomas, Sinn, Hans Peter, Warm, Mathias, van Mackelenbergh, Marion, Rabizadeh, Sharooz, Schem, Christian, Heinmöller, Ernst, Müller, Volkmar, Marmé, Frederik, Soon-Shiong, Patrick, Nekljudova, Valentina, Untch, Michael, Loibl, Sibylle

“…Background: Tumor immune markers such as tumor infiltrating lymphocytes (TILs) or expression-based profiles have been correlated with both response to…”
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Abstract P6-10-04: Landscape of immune-cell signatures in early high-risk breast cancer (BC) reveals clinically-relevant enrichment of immune subpopulations by Szeto, Christopher, Denkert, Carsten, Fasching, Peter A, Benz, Stephen, Weber, Karsten E, Budczies, Jan, Schneeweiss, Andreas, Stickeler, Elmar, Schmatloch, Sabine, Jackisch, Christian, Karn, Thomas, Sinn, Hans P, Warm, Mathias, van Mackelenbergh, Marion, Rabizadeh, Shahrooz, Schem, Christian, Heinmöller, Ernst, Müller, Volkmar, Marmé, Frederik, Soon-Shiong, Patrick, Nekljudova, Valentina, Loibl, Sibylle, Untch, Michael

“…Background: Immunosurveillance suppression, evasion, or avoidance, has emerged as a key targetable hallmark of cancer, driven by e.g. checkpoint expression,…”
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Plasma Membrane Calcium ATPase Expression in Human Colon Multistep Carcinogenesis by Rüschoff, Jan H., Brandenburger, Timo, Strehler, Emanuel E., Filoteo, Adelaida G., Heinmöller, Ernst, Aumüller, Gerhard, Wilhelm, Beate

“…The expression of the plasma membrane Ca2+ ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal…”
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Laser Microdissection of Small Tissue Samples – Application to Chronic Pancreatitis Tissues by Heinmöller, Ernst, Bockholt, Anke, Werther, Meike, Ziemer, Maria, Müller, Annegret, Ghadimi, B. Michael, Rüschoff, Josef

“…Laser microdissection is considered to be the gold standard of tissue sampling, especially if a defined small tissue area consisting of single or few cells…”
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Microsatellite Analysis of Hereditary Nonpolyposis Colorectal Cancer-Associated Colorectal Adenomas by Laser-Assisted Microdissection: Correlation with Mismatch Repair Protein Expression Provides New Insights in Early Steps of Tumorigenesis by Giuffre, Giuseppe, Muller, Annegret, Brodegger, Thomas, Bocker-Edmonston, Tina, Gebert, Johannes, Kloor, Matthias, Dietmaier, Wolfgang, Kullmann, Frank, Buttner, Reinhard, Tuccari, Giovanni, Ruschoff, Josef, German HNPCC Consortium, German Cancer Aid, (Deutsche Krebshilfe)

“…Although microsatellite instability (MSI) testing is a useful tool for molecular screening of hereditary nonpolyposis colorectal cancer (HNPCC) carcinomas,…”
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Intraepithelial neoplasms (PanIN) and intraductal papillary-mucinous neoplasms (IPMN) of the pancreas as precursor lesions of pancreatic carcinoma by Ott, Claudia, Heinmöller, Ernst, Gaumann, Andreas, Schölmerich, Jürgen, Klebl, Frank

“…Due to the fatal prognosis of pancreatic carcinoma, great efforts have been made to investigate precursor lesions of invasive neoplasia during the last few…”
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Molecular genetic analysis of surveillance biopsy samples from Barrett's mucosa – Significance of sampling by Werther, Meike, Saure, Christoph, Pahl, René, Schorr, Friedrich, Rüschoff, Josef, Alles, Jens Uwe, Heinmöller, Ernst

“…Our aim was to determine the spectrum and accumulation of mutations in surveillance biopsies from Barrett's mucosa of individual patients during follow-up. We…”
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Pitfalls in diagnostic molecular pathology - significance of sampling error by HEINMÖLLER, Ernst, RENKE, Birgit, BEYSER, Kurt, DIETMAIER, Wolfgang, LANGNER, Cord, RÜSCHOFF, Josef

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Abstract P1-10-01: Caveolin gene expression predicts for response and clinical outcomes of patients treated with preoperative paclitaxel-based chemotherapy regimens in early stage breast cancer by Williams, Terence, Schneeweiss, Andreas, Jackisch, Christian, Shen, Changxian, Weber, Karsten, Fasching, Peter, Denkert, Carsten, Furlanetto, Jenny, Heinmoller, Ernst, Schmatloch, Sabine, Karn, Thomas, Szeto, Christopher, van Mackelenbergh, Marion, Nekljudova, Valentina, Stickeler, Elmar, Soon-Shiong, Patrick, Schem, Christian, Fleige, Barbara, Muller, Volkmar, Marme, Frederik, Untch, Michael, Loibl, Sibylle

“…Background: Biomarkers are needed to prognosticate and predict efficacy of therapy for patients undergoing neoadjuvant chemotherapy for HER2-negative breast…”
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