Search Results - "Heinloth, Alexandra N"

Therapeutic Options for Treatment-Resistant Depression by Shelton, Richard C., Osuntokun, Olawale, Heinloth, Alexandra N., Corya, Sara A.

“…Treatment-resistant depression (TRD) presents major challenges for both patients and clinicians. There is no universally accepted definition of TRD, but…”
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An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage by Heffernan, Timothy P., Simpson, Dennis A., Frank, Alexandra R., Heinloth, Alexandra N., Paules, Richard S., Cordeiro-Stone, Marila, Kaufmann, William K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gene Expression Profiling of Rat Livers Reveals Indicators of Potential Adverse Effects by Heinloth, Alexandra N., Irwin, Richard D., Boorman, Gary A., Nettesheim, Paul, Fannin, Rickie D., Sieber, Stella O., Snell, Michael L., Tucker, Charles J., Li, Leping, Travlos, Gregory S., Vansant, Gordon, Blackshear, Pamela E., Tennant, Raymond W., Cunningham, Michael L., Paules, Richard S.

“…This study tested the hypothesis that gene expression profiling can reveal indicators of subtle injury to the liver induced by a low dose of a substance that…”
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Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants by Huang, Lingkang, Heinloth, Alexandra N, Zeng, Zhao-Bang, Paules, Richard S, Bushel, Pierre R

“…Some of the biochemical events that lead to necrosis of the liver are well-known. However, the pathogenesis of necrosis of the liver from exposure to…”
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Cdc7-Dbf4 and the Human S Checkpoint Response to UVC by Heffernan, Timothy P., Ünsal-Kaçmaz, Keziban, Heinloth, Alexandra N., Simpson, Dennis A., Paules, Richard S., Sancar, Aziz, Cordeiro-Stone, Marila, Kaufmann, William K.

“…The S checkpoint response to ultraviolet radiation (UVC) that inhibits replicon initiation is dependent on the ATR and Chk1 kinases. Downstream effectors of…”
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Application of Toxicogenomics to Toxicology: Basic Concepts in the Analysis of Microarray Data by Irwin, Richard D., Boorman, Gary A., Cunningham, Michael L., Heinloth, Alexandra N., Malarkey, David E., Paules, Richard S.

“…Toxicology and the practice of pathology are rapidly evolving in the postgenomic era. Observable treatment related changes have been the hallmark of toxicology…”
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Gene set enrichment analysis for non-monotone association and multiple experimental categories by Lin, Rongheng, Dai, Shuangshuang, Irwin, Richard D, Heinloth, Alexandra N, Boorman, Gary A, Li, Leping

“…Recently, microarray data analyses using functional pathway information, e.g., gene set enrichment analysis (GSEA) and significance analysis of function and…”
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Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis by Stauffer, Virginia L, Lipkovich, Ilya, Hoffmann, Vicki Poole, Heinloth, Alexandra N, McGregor, H Scott, Kinon, Bruce J

“…This study focuses on exploring the relationship between changes in appetite or eating behaviors and subsequent weight change for adult patients with…”
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Failure to Replicate Genetic Associations with Antidepressant Treatment Response in Duloxetine-Treated Patients by Perlis, Roy H, Fijal, Bonnie, Dharia, Sweta, Heinloth, Alexandra N, Houston, John P

“…Background Recent studies have identified associations of polymorphisms in several target genes with antidepressant treatment response of serotonin reuptake…”
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Review of Efficacy and Safety of Duloxetine 40 to 60 mg Once Daily in Patients with Diabetic Peripheral Neuropathic Pain by Skljarevski, Vladimir, Frakes, Elijah P., Sagman, Doron, Lipsius, Sarah, Heinloth, Alexandra N., Dueñas Tentori, Héctor J.

“…We summarize efficacy and safety findings from 4 double-blind, placebo-controlled, 12-week studies and 1 open-label, uncontrolled, 34-week…”
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ATM Requirement in Gene Expression Responses to Ionizing Radiation in Human Lymphoblasts and Fibroblasts by Innes, Cynthia L, Heinloth, Alexandra N, Flores, Kristina G, Sieber, Stella O, Deming, Paula B, Bushel, Pierre R, Kaufmann, William K, Paules, Richard S

“…The heritable disorder ataxia telangiectasia (AT) is caused by mutations in the AT-mutated ( ATM ) gene with manifestations that include predisposition to…”
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Double-blind, randomized trial comparing efficacy and safety of continuing olanzapine versus switching to quetiapine in overweight or obese patients with schizophrenia or schizoaffective disorder by Deberdt, Walter, Lipkovich, Ilya, Heinloth, Alexandra N, Liu, Lin, Kollack-Walker, Sara, Edwards, Sara E, Hoffmann, Vicki Poole, Hardy, Thomas A

“…We examined the potential risks and benefits of switching from olanzapine to quetiapine in mentally stable, obese, or overweight patients with schizophrenia or…”
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Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation by Heinloth, Alexandra N., Shackelford, Rodney E., Innes, Cynthia L., Bennett, Lee, Li, Leping, Amin, Rupesh P., Sieber, Stella O., Flores, Kristina G., Bushel, Pierre R., Paules, Richard S.

“…The human genome is exposed to many different kinds of DNA‐damaging agents. While most damage is detected and repaired through complex damage recognition and…”
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Validation of the adult attention-deficit/hyperactivity disorder quality-of-life scale in European patients: comparison with patients from the USA by Brod, Meryl, Adler, Lenard A., Lipsius, Sarah, Tanaka, Yoko, Heinloth, Alexandra N., Upadhyaya, Himanshu

“…The adult attention-deficit/hyperactivity disorder (ADHD) quality-of-life (AAQoL) scale was previously validated in adult patients in the USA; here, the AAQoL…”
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The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder by Fijal, Bonnie, Perlis, Roy H, Heinloth, Alexandra N, Houston, John P

“…We tested the hypothesis that single nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase (COMT) gene are associated with baseline pain levels…”
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Association of Common Variations in the Norepinephrine Transporter Gene With Response to Olanzapine-Fluoxetine Combination Versus Continued-Fluoxetine Treatment in Patients With Treatment-Resistant Depression: A Candidate Gene Analysis by HOUSTON, John P, LAU, Kit, ARIS, Virginie, WENLEI LIU, FIJAL, Bonnie A, HEINLOTH, Alexandra N, PERLIS, Roy H

“…To determine whether single-nucleotide polymorphisms (SNPs) in candidate genes are associated with response to olanzapine-fluoxetine combination. A post hoc…”
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Evaluation of genetic models for response in a randomized clinical trial of duloxetine in major depressive disorder by Houston, John P, Zou, Wei, Aris, Virginie, Fijal, Bonnie, Chen, Peining, Heinloth, Alexandra N, Martinez, James

“…Abstract In self-identified white patients with major depressive disorder ( N =126) treated with open-label duloxetine (60–120 mg/d), a significant association…”
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Early improvement in pain predicts pain response at endpoint in patients with fibromyalgia by Wang, Fujun, Ruberg, Stephen J, Gaynor, Paula J, Heinloth, Alexandra N, Arnold, Lesley M

“…An unanswered, but clinically important question is whether there are early indicators that a patient might respond to duloxetine treatment for fibromyalgia…”
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Genetic associations of prolactin increase in olanzapine/fluoxetine combination-treated patients by Houston, John P, Fijal, Bonnie, Heinloth, Alexandra N, Adams, David H

“…Abstract In patients from two clinical trials, we investigated the associations of single nucleotide polymorphisms (SNPs) in candidate genes with prolactin…”
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Phenotypic Anchoring of Acetaminophen-Induced Oxidative Stress with Gene Expression Profiles in Rat Liver by Powell, Christine L., Kosyk, Oksana, Ross, Pamela K., Schoonhoven, Robert, Boysen, Gunnar, Swenberg, James A., Heinloth, Alexandra N., Boorman, Gary A., Cunningham, Michael L., Paules, Richard S., Rusyn, Ivan

“…Toxicogenomics provides the ability to examine in greater detail the underlying molecular events that precede and accompany toxicity, thus allowing prediction…”
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