Search Results - "Heinken, Almut"
-
1
Gut microbiota functions: metabolism of nutrients and other food components
Published in European journal of nutrition (01-02-2018)“…The diverse microbial community that inhabits the human gut has an extensive metabolic repertoire that is distinct from, but complements the activity of…”
Get full text
Journal Article -
2
Metabolic modelling reveals broad changes in gut microbial metabolism in inflammatory bowel disease patients with dysbiosis
Published in NPJ systems biology and applications (06-05-2021)“…Inflammatory bowel diseases, such as Crohn’s Disease, are characterised by an altered blood and faecal metabolome, and changes in gut microbiome composition…”
Get full text
Journal Article -
3
A structured evaluation of genome-scale constraint-based modeling tools for microbial consortia
Published in PLoS computational biology (14-08-2023)“…Harnessing the power of microbial consortia is integral to a diverse range of sectors, from healthcare to biotechnology to environmental remediation. To fully…”
Get full text
Journal Article -
4
Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota
Published in Nature biotechnology (01-01-2017)“…A large set of microbial metabolic models (AGORA) could be applied to better understand the functions of the human gut microbiome. Genome-scale metabolic…”
Get full text
Journal Article -
5
Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome
Published in Molecular systems biology (01-05-2020)“…Comprehensive molecular‐level models of human metabolism have been generated on a cellular level. However, models of whole‐body metabolism have not been…”
Get full text
Journal Article -
6
Systematic prediction of health-relevant human-microbial co-metabolism through a computational framework
Published in Gut microbes (04-03-2015)“…The gut microbiota is well known to affect host metabolic phenotypes. The systemic effects of the gut microbiota on host metabolism are generally evaluated via…”
Get full text
Journal Article -
7
Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease
Published in Microbiome (15-05-2019)“…The human gut microbiome performs important functions in human health and disease. A classic example for host-gut microbial co-metabolism is host biosynthesis…”
Get full text
Journal Article -
8
Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta
Published in PLoS biology (19-05-2023)“…Human gut bacteria perform diverse metabolic functions with consequences for host health. The prevalent and disease-linked Actinobacterium Eggerthella lenta…”
Get full text
Journal Article -
9
Integration of constraint-based modeling with fecal metabolomics reveals large deleterious effects of Fusobacterium spp. on community butyrate production
Published in Gut microbes (01-01-2021)“…Characterizing the metabolic functions of the gut microbiome in health and disease is pivotal for translating alterations in microbial composition into…”
Get full text
Journal Article -
10
Functional Metabolic Map of Faecalibacterium prausnitzii, a Beneficial Human Gut Microbe
Published in Journal of bacteriology (01-09-2014)“…The human gut microbiota plays a central role in human well-being and disease. In this study, we present an integrated, iterative approach of computational…”
Get full text
Journal Article -
11
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease
Published in Cell reports (Cambridge) (12-11-2019)“…Parkinson’s disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal…”
Get full text
Journal Article -
12
Systems-level characterization of a host-microbe metabolic symbiosis in the mammalian gut
Published in Gut microbes (01-01-2013)“…The human gut microbiota consists of ten times more microorganisms than there are cells in our body, processes otherwise indigestible nutrients, and produces…”
Get full text
Journal Article -
13
Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells
Published in Cell reports (Cambridge) (30-04-2019)“…By modulating the human gut microbiome, prebiotics and probiotics (combinations of which are called synbiotics) may be used to treat diseases such as…”
Get full text
Journal Article -
14
Longitudinal flux balance analyses of a patient with episodic colonic inflammation reveals microbiome metabolic dynamics
Published in Gut microbes (31-12-2023)“…We report the first use of constraint-based microbial community modeling on a single individual with episodic inflammation of the gastrointestinal tract, who…”
Get full text
Journal Article -
15
Causal inference on microbiome-metabolome relations in observational host-microbiome data via in silico in vivo association pattern analyses
Published in Cell reports methods (23-10-2023)“…Understanding the effects of the microbiome on the host’s metabolism is core to enlightening the role of the microbiome in health and disease. Herein, we…”
Get full text
Journal Article -
16
A systematic review and meta-analysis of proteomic and metabolomic alterations in anaphylaxis reactions
Published in Frontiers in immunology (07-02-2024)“…Anaphylaxis manifests as a severe immediate-type hypersensitivity reaction initiated through the immunological activation of target B-cells by allergens,…”
Get full text
Journal Article -
17
A systems biology approach to drug targets in Pseudomonas aeruginosa biofilm
Published in PloS one (16-04-2012)“…Antibiotic resistance is an increasing problem in the health care system and we are in a constant race with evolving bacteria. Biofilm-associated growth is…”
Get full text
Journal Article -
18
A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes
Published in mSystems (17-09-2024)“…is responsible for a range of diseases in humans contributing significantly to morbidity and mortality. Among more than 200 serotypes of , serotype M1 strains…”
Get full text
Journal Article -
19
NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health
Published in Metabolites (31-03-2022)“…Microbial metabolites measured using NMR may serve as markers for physiological or pathological host-microbe interactions and possibly mediate the beneficial…”
Get full text
Journal Article -
20
Microbiome Modelling Toolbox 2.0: efficient, tractable modelling of microbiome communities
Published in Bioinformatics (12-04-2022)“…Abstract Motivation Constraint-Based Reconstruction and Analysis (COBRA) is a widely used approach for the interrogation and stratification of microbiome…”
Get full text
Journal Article