Search Results - "Heinisch, Jürgen"

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling by Arimoto, Kei-ichiro, Löchte, Sara, Stoner, Samuel A, Burkart, Christoph, Zhang, Yue, Miyauchi, Sayuri, Wilmes, Stephan, Fan, Jun-Bao, Heinisch, Jürgen J, Li, Zhi, Yan, Ming, Pellegrini, Sandra, Colland, Frédéric, Piehler, Jacob, Zhang, Dong-Er

“…STAT2, previously known as a positive effector of interferon signaling, is now shown to participate in negative feedback and suppression of this signaling…”
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How to study intertwined and autoregulated eukaryotic signal transduction pathways by Heinisch, Jürgen J.

“…Mitogen‐activated protein kinase (MAPK) pathways are a major means of eukaryotic cells to adapt to environmental changes, in the case of microorganisms, and to…”
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Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport by Conze, Christian, Rierola, Marina, Trushina, Nataliya I., Peters, Michael, Janning, Dennis, Holzer, Max, Heinisch, Jürgen J., Arendt, Thomas, Bakota, Lidia, Brandt, Roland

“…The microtubule-associated protein tau plays a central role in tauopathies such as Alzheimer’s disease (AD). The exact molecular mechanisms underlying tau…”
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High-Resolution Imaging of Chemical and Biological Sites on Living Cells Using Peak Force Tapping Atomic Force Microscopy by Alsteens, David, Dupres, Vincent, Yunus, Sami, Latgé, Jean-Paul, Heinisch, Jürgen J, Dufrêne, Yves F

“…Currently, there is a growing need for methods that can quantify and map the molecular interactions of biological samples, both with high-force sensitivity and…”
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Yeast cell wall integrity sensors form specific plasma membrane microdomains important for signalling by Kock, Christian, Arlt, Henning, Ungermann, Christian, Heinisch, Jürgen J.

“…Summary The cell wall integrity (CWI) pathway of the yeast Saccharomyces cerevisiae relies on the detection of cell surface stress by five sensors (Wsc1, Wsc2,…”
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Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides by Schiemann, Ronja, Buhr, Annika, Cordes, Eva, Walter, Stefan, Heinisch, Jürgen J., Ferrero, Paola, Milting, Hendrik, Paululat, Achim, Meyer, Heiko

“…Muscle contraction depends on strictly controlled Ca 2+ transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic…”
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Posttranscriptional expression regulation: what determines translation rates? by Brockmann, Regina, Beyer, Andreas, Heinisch, Jürgen J, Wilhelm, Thomas

“…Recent analyses indicate that differences in protein concentrations are only 20%-40% attributable to variable mRNA levels, underlining the importance of…”
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A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function by Dehnen, Lena, Janz, Maren, Verma, Jitender Kumar, Psathaki, Olympia Ekaterini, Langemeyer, Lars, Fröhlich, Florian, Heinisch, Jürgen J, Meyer, Heiko, Ungermann, Christian, Paululat, Achim

“…Endosome biogenesis in eukaryotic cells is critical for nutrient uptake and plasma membrane integrity. Early endosomes initially contain Rab5, which is…”
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Yeast on the milky way: genetics, physiology and biotechnology of Kluyveromyces lactis by Rodicio, Rosaura, Heinisch, Jürgen J.

“…The milk yeast Kluyveromyces lactis has a life cycle similar to that of Saccharomyces cerevisiae and can be employed as a model eukaryote using classical…”
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Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons by Janning, Dennis, Igaev, Maxim, Sündermann, Frederik, Brühmann, Jörg, Beutel, Oliver, Heinisch, Jürgen J, Bakota, Lidia, Piehler, Jacob, Junge, Wolfgang, Brandt, Roland

“…The microtubule-associated phosphoprotein tau regulates microtubule dynamics and is involved in neurodegenerative diseases collectively called tauopathies. It…”
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The Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis by Bertels, Laura-Katharina, Fernández Murillo, Lucía, Heinisch, Jürgen J.

“…The pentose phosphate pathway (PPP) is a route that can work in parallel to glycolysis in glucose degradation in most living cells. It has a unidirectional…”
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Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae by Bartölke, Rabea, Heinisch, Jürgen J, Wieczorek, Helmut, Vitavska, Olga

“…The members of the solute carrier 45 (SLC45) family have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair…”
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Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae by Esch, Bianca M, Limar, Sergej, Bogdanowski, André, Gournas, Christos, More, Tushar, Sundag, Celine, Walter, Stefan, Heinisch, Jürgen J, Ejsing, Christer S, André, Bruno, Fröhlich, Florian, Copenhaver, Gregory P, Dudley, Aimee M

“…Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid…”
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Up against the wall: is yeast cell wall integrity ensured by mechanosensing in plasma membrane microdomains? by Kock, Christian, Dufrêne, Yves F, Heinisch, Jürgen J

“…Yeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of…”
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Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium by Vázquez, Xenia, García, Patricia, García, Vanesa, de Toro, María, Ladero, Víctor, Heinisch, Jürgen J., Fernández, Javier, Rodicio, Rosaura, Rodicio, M. Rosario

“…pUO-STmRV1 is an IncC plasmid discovered in the Spanish clone of the emergent monophasic variant of Salmonella enterica serovar Typhimurium, which has probably…”
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A Versatile Toolset for Genetic Manipulation of the Wine Yeast Hanseniaspora uvarum by Heinisch, Jürgen J, Murra, Andrea, Jürgens, Kai, Schmitz, Hans-Peter

“…is an ascomycetous yeast that frequently dominates the population in the first two days of wine fermentations. It contributes to the production of many…”
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The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation by Schmitz, Hans-Peter, Jendretzki, Arne, Sterk, Carolin, Heinisch, Jürgen J

“…Rho5 is a small GTPase of and a homolog of mammalian Rac1. The latter regulates glucose metabolism and actin cytoskeleton dynamics, and its misregulation…”
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The Intracellular Distribution of the Small GTPase Rho5 and Its Dimeric Guanidine Nucleotide Exchange Factor Dck1/Lmo1 Determine Their Function in Oxidative Stress Response by Bischof, Linnet, Schweitzer, Franziska, Sterk, Carolin C., Heinisch, Jürgen J.

“…Rho5, the yeast homolog of human Rac1, is a small GTPase which regulates the cell response to nutrient and oxidative stress by inducing mitophagy and…”
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Functional Conservation of the Small GTPase Rho5/Rac1-A Tale of Yeast and Men by Bischof, Linnet, Schweitzer, Franziska, Heinisch, Jürgen J

“…Small GTPases are molecular switches that participate in many essential cellular processes. Amongst them, human Rac1 was first described for its role in…”
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Together we are strong--cell wall integrity sensors in yeasts by Rodicio, Rosaura, Heinisch, Jürgen J

“…The integrity of the fungal cell wall is ensured by a signal transduction pathway, the so-called CWI pathway, which has best been studied in the model yeast…”
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