Search Results - "Heinisch, Gottfried"

Synthesis, Structure−Activity Relationships, and Antitumor Studies of 2-Benzoxazolyl Hydrazones Derived from Alpha-(N)-acyl Heteroaromatics by Easmon, Johnny, Pürstinger, Gerhard, Thies, Katrin-Sofia, Heinisch, Gottfried, Hofmann, Johann

“…Recently we have described the antitumor activities of 2-benzoxazolylhydrazones derived from 2-formyl and 2-acetylpyridines. In search of a more efficacious…”
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Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines by EASMON, Johnny, PüRSTINGER, Gerhard, HEINISCH, Gottfried, ROTH, Thomas, FIEBIG, Heinz H., HOLZER, Wolfgang, JäGER, Walter, JENNY, Marcel, HOFMANN, Johann

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Synthesis, Cytotoxic, and Antitumor Activities of 2-Pyridylhydrazones Derived from 3-Benzoylpyridazines by Easmon, Johnny, Pürstinger, Gerhard, Heinisch, Gottfried, Fiebig, Hans H., Roth, Thomas, Hofmann, Johann

“…A series of 2‐pyridylhydrazones derived from phenyl‐pyridazin‐3‐yl‐methanones were prepared in search for potential novel antitumor agents. The stereochemistry…”
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2‐benzoxazolyl and 2‐benzimidazolyl hydrazones derived from 2‐acetylpyridine: A novel class of antitumor agents by Easmon, Johnny, Puerstinger, Gerhard, Roth, Thomas, Fiebig, Heinz‐Herbert, Jenny, Marcel, Jaeger, Walter, Heinisch, Gottfried, Hofmann, Johann

“…Here we describe the effects of novel benzoxazol‐2‐yl and benzimidazol‐2‐yl hydrazones derived from 2‐pyridinecarbaldehyde and 2‐acetylpyridine. The IC50…”
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Pyridazines XLII. On the Synthesis of N-5-substitutes Pyridazino[4,5-b]quinolin-10(5H)-ones by Heinisch, Gottfried, Hainder, Norbert, Volf, Ivo

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Substituted Pyridazino[3,4-b][1,5]benzoxazepin-5(6H)ones as Multidrug-Resistance Modulating Agents by Ott, Ingo, Kircher, Brigitte, Heinisch, Gottfried, Matuszczak, Barbara

“…Pyridazino[3,4-b][1,5]benzoxazepin-5(6H)ones substituted with propylene-linked basic side chains were synthesized and investigated for the ability to reverse…”
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N-benzoxazol-2-yl-N′-1-(isoquinolin-3-yl-ethylidene)-hydrazine, a novel compound with antitumor activity, induces radicals and dissipation of mitochondrial membrane potential by Hofmann, Johann, Easmon, Johnny, Puerstinger, Gerhard, Heinisch, Gottfried, Jenny, Marcel, Shtil, Alexander A., Hermann, Martin, Condorelli, Daniele F., Sciré, Salvatore, Musumarra, Giuseppe

“…Summary The novel compound N -benzoxazol-2-yl- N ′-1-(isoquinolin-3-yl-ethylidene)-hydrazine (EPH136) has been shown to exhibit antitumor activity in vitro and…”
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Pharmacologically active pyridazine derivatives. Part 2 by Heinisch, G, Kopelent-Frank, H

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Diazine-derived guanidines, isothioureas, and isoureas: Synthesis and attempts of configurational assignment by Heinisch, Gottfried, Matuszczak, Barbara, Rakowitz, Dietmar, Mereiter, Kurt

“…The utility of diazinyl substituted carbodiimides (1a‐c) for the synthesis of novel guanidines (2), isothioureas (3), and isoureas (4) is shown. Attempts to…”
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Novel thiosemicarbazones derived from formyl- and acyldiazines : synthesis, effects of cell proliferation, and synergism with antiviral agents by EASMON, J, HEINISCH, G, HOLZER, W, ROSENWIRTH, B

“…The synthesis of a series of novel thiosemicarbazones (TSC's) derived from various alkyl diazinyl (3-pyridazinyl, 4-pyrimidinyl, 2-pyrazinyl) ketones and…”
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Investigations on the Mechanism of Action of the Novel Antitumor Agents 2-Benzothiazolyl, 2-Benzoxazolyl, and 2-Benzimidazolyl Hydrazones Derived from 2-Acetylpyridine by Hall, Iris H., Peaty, Nathanael J., Henry, Jennifer R., Easmon, Johnny, Heinisch, Gottfried, Pürstinger, Gerhard

“…2‐Acetylpyridine hydrazone derivatives of benzothiazole, benzoxazole, and benzimidazole were found to exhibit potent cytotoxic activity against the growth of…”
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Pyridazines, 90. On the Synthesis of Novel 1,2-Diazine Containing Tricyclic Systems: Preparation of Tetraazaphenazines by Matuszczak, Barbara, Heinisch, Gottfried, Huber, Elisabeth

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Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4 N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines by Easmon, Johnny, Pürstinger, Gerhard, Heinisch, Gottfried, Roth, Thomas, Fiebig, Heinz H, Holzer, Wolfgang, Jäger, Walter, Jenny, Marcel, Hofmann, Johann

“…A series of thiosemicarbazones (TSCs) (bearing a 4N-azabicyclo[3.2.2]nonane moiety) derived from 3-acylpyridazines, 4-acetylpyrimidines, and 2-acetylpyrazines…”
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Pharmacologically active pyridazine derivatives. Part 1 by Heinisch, G, Frank, H

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Pyridazines LXXVIII On the reactivity of 4-methoxy-[(4-pyridazinyl)methylidene]aniline in ester enolate-imine condensation reactions by Heinisch, Gottfried, Langer, Thierry, Tonnel, Jacques

“…Reactions of the pyridazine derived aldimine 1 with lithium enolates of various α‐substituted acetates were investigated. An unprecedented formation of the…”
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Advances in the Synthesis of Substituted Pyridazines via Introduction of Carbon Functional Group into the Parent heterocycle by Heinisch, Gottfried

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Synthesis of Substituted Tri- and Tetracyclic Compounds Bearing a Pyridazine Core and their Biological Evaluation as Antimycobacterial Agents by Heinisch, Gottfried, Matuszczak, Barbara, Planitzer, Karin

“…Starting from substituted 3,6‐dichloropyridazine‐4‐carboxamides (2, 3) tri‐ and tetracyclic compounds (4, 5) could be smoothly prepared. Structural…”
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Novel diazinyl 3-pyridyl ketones: Efficient synthesis and complete assignment of 1H and 13C NMR spectra by Heinisch, Gottfried, Langer, Thierry, Lukavsky, Peter

“…The preparation of six diazinyl 3‐pyridyl ketones 3–8 is described. Detailed 1H and 13C nmr data of these novel building blocks are given…”
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Novel diazinyl 3‐pyridyl ketones: Efficient synthesis and complete assignment of 1 H and 13 C NMR spectra by Heinisch, Gottfried, Langer, Thierry, Lukavsky, Peter

“…Abstract The preparation of six diazinyl 3‐pyridyl ketones 3–8 is described. Detailed 1 H and 13 C nmr data of these novel building blocks are given…”
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Pyridazines. 84. Pyridazino[3,4-e]pyrido[3,2-b][1,4]diazepine, a novel tricyclic ring system by Heinisch, Gottfried, Matuszczak, Barbara

“…The preparation of pyridazino[3,4‐e]pyrido[3,2‐b][1,4]diazepin‐5‐ones 8 and 9 starting from appropriately substituted pyridazine‐4‐carboxamides is reported…”
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