Search Results - "Heiniö, Camilla"

Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes by Zafar, Sadia, Quixabeira, Dafne Carolina Alves, Kudling, Tatiana Viktorovna, Cervera-Carrascon, Victor, Santos, Joao Manuel, Grönberg-Vähä-Koskela, Susanna, Zhao, Fang, Aronen, Pasi, Heiniö, Camilla, Havunen, Riikka, Sorsa, Suvi, Kanerva, Anna, Hemminki, Akseli

“…Oncolytic adenoviruses are promising cancer therapeutic agents. Clinical data have shown adenoviruses’ ability to transduce tumors after systemic delivery in…”
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TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling by Heiniö, Camilla, Havunen, Riikka, Santos, Joao, de Lint, Klaas, Cervera-Carrascon, Victor, Kanerva, Anna, Hemminki, Akseli

“…In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic…”
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Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 by Quixabeira, Dafne C. A., Cervera-Carrascon, Victor, Santos, Joao M., Clubb, James H.A., Kudling, Tatiana V., Basnet, Saru, Heiniö, Camilla, Grönberg-Vähä-Koskela, Susanna, Anttila, Marjukka, Havunen, Riikka, Kanerva, Anna, Hemminki, Akseli

“…Intratumoral immunotherapies are entering clinical use but concerns remain regarding their effects on non-injected tumors. Here, we studied the impact of local…”
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Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity by Santos, João Manuel, Heiniö, Camilla, Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Siurala, Mikko, Havunen, Riikka, Butzow, Ralf, Zafar, Sadia, de Gruijl, Tanja, Lassus, Heini, Kanerva, Anna, Hemminki, Akseli

“…BackgroundOvarian cancers often contain significant numbers of tumor-infiltrating lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy…”
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Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1 by Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Santos, Joao M, Havunen, Riikka, Milenova, Ioanna, Verhoeff, Jan, Heiniö, Camilla, Zafar, Sadia, Garcia-Vallejo, Juan J, van Beusechem, Victor W, de Gruijl, Tanja D, Kalervo, Aino, Sorsa, Suvi, Kanerva, Anna, Hemminki, Akseli

“…Immune checkpoint inhibitors such as anti-PD-1 have revolutionized the field of oncology over the past decade. Nevertheless, the majority of patients do not…”
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Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers by Santos, Joao, Heiniö, Camilla, Quixabeira, Dafne, Zafar, Sadia, Clubb, James, Pakola, Santeri, Cervera-Carrascon, Victor, Havunen, Riikka, Kanerva, Anna, Hemminki, Akseli

“…Immunotherapy with tumor-infiltrating lymphocytes (TIL) or oncolytic adenoviruses, have shown promising results in cancer treatment, when used as separate…”
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Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer by Clubb, James H A, Kudling, Tatiana V, Heiniö, Camilla, Basnet, Saru, Pakola, Santeri, Cervera Carrascón, Víctor, Santos, João Manuel, Quixabeira, Dafne C A, Havunen, Riikka, Sorsa, Suvi, Zheng, Vincent, Salo, Tuula, Bäck, Leif, Aro, Katri, Tulokas, Sanni, Loimu, Venla, Hemminki, Akseli

“…Immune checkpoint inhibitors (ICI) have provided significant improvement in clinical outcomes for some patients with solid tumors. However, for patients with…”
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Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition by Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Santos, Joao Manuel, Havunen, Riikka, Zafar, Sadia, Hemminki, Otto, Heiniö, Camilla, Munaro, Eleonora, Siurala, Mikko, Sorsa, Suvi, Mirtti, Tuomas, Järvinen, Petrus, Mildh, Markus, Nisen, Harry, Rannikko, Antti, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

“…Checkpoint inhibitors have revolutionized cancer therapy and validated immunotherapy as an approach. Unfortunately, responses are seen in a minority of…”
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Effect of Genetic Modifications on Physical and Functional Titers of Adenoviral Cancer Gene Therapy Constructs by Heiniö, Camilla, Sorsa, Suvi, Siurala, Mikko, Grönberg-Vähä-Koskela, Susanna, Havunen, Riikka, Haavisto, Elina, Koski, Anniina, Hemminki, Otto, Zafar, Sadia, Cervera-Carrascon, Víctor, Munaro, Eleonora, Kanerva, Anna, Hemminki, Akseli

“…After the discovery and characterization of the adenovirus in the 1950s, this prevalent cause of the common cold and other usually mild diseases has been…”
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Effective Combination Immunotherapy with Oncolytic Adenovirus and Anti-PD-1 for Treatment of Human and Murine Ovarian Cancers by Heiniö, Camilla, Clubb, James, Kudling, Tatiana, Quixabeira, Dafne, Cervera-Carrascon, Victor, Havunen, Riikka, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Tapper, Johanna, Kanerva, Anna, Hemminki, Akseli

“…Ovarian cancer (OvCa) is one of the most common gynecological cancers and has the highest mortality in this category. Tumors are often detected late, and…”
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The Unexplored Diversity of Pleolipoviruses: The Surprising Case of Two Viruses with Identical Major Structural Modules by Atanasova, Nina S, Heiniö, Camilla H, Demina, Tatiana A, Bamford, Dennis H, Oksanen, Hanna M

“…Extremely halophilic are the only known hosts for pleolipoviruses which are pleomorphic non-lytic viruses resembling cellular membrane vesicles. Recently,…”
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Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors by Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C.A., Clubb, James H.A., Grönberg-Vähä-Koskela, Susanna A.M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

“…Immunotherapy with bispecific T cell engagers has shown efficacy in patients with hematologic malignancies and uveal melanoma. Antitumor effects of bispecific…”
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An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage by Pakola, Santeri, Quixabeira, Dafne C A, Kudling, Tatiana V, Clubb, James H A, Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M, Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly treatment-resistant cancer. Currently, the only curative treatment for PDAC is surgery, but most patients…”
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Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors by Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Havunen, Riikka, Santos, Joao M., Kutvonen, Emma, Clubb, James H.A., Siurala, Mikko, Heiniö, Camilla, Zafar, Sadia, Koivula, Teija, Lumen, Dave, Vaha, Marjo, Garcia-Horsman, Arturo, Airaksinen, Anu J., Sorsa, Suvi, Anttila, Marjukka, Hukkanen, Veijo, Kanerva, Anna, Hemminki, Akseli

“…Despite some promising results, the majority of patients do not benefit from T cell therapies, as tumors prevent T cells from entering the tumor, shut down…”
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814 Enhancing anti-tumor response in ICI-refractory non-small cell lung cancer through intravenous administration of oncolytic adenovirus armed with hTNFα and hIL-2 in combination with aPD-1 blockade by Kudling, Tatiana V, Clubb, James, Pakola, Santeri A, Quixabeira, Dafne Alves, Lähdeniemi, Iris, Heiniö, Camilla, Arias, Victor, Grönberg-Vähä-Koskela, Susanna AM, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao Manuel, Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko, Altonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W, Ilonen, Ilkka, Hemminki, Akseli

“…BackgroundDespite significant achievements in targeted and immunotherapies, including immune checkpoint inhibitors (ICI), treatment outcomes for advanced…”
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Oncolytic adenovirus for treatment of malignant ascites by Hemminki, Akseli, Heiniö, Camilla

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Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression by Kudling, Tatiana V., Clubb, James H.A., Quixabeira, Dafne C.A., Santos, Joao M., Havunen, Riikka, Kononov, Alexander, Heiniö, Camilla, Cervera-Carrascon, Victor, Pakola, Santeri, Basnet, Saru, Grönberg-Vähä-Koskela, Susanna, Arias, Victor, Gladwyn-Ng, Ivan, Aro, Katri, Bäck, Leif, Räsänen, Jari, Ilonen, Ilkka, Borenius, Kristian, Räsänen, Mikko, Hemminki, Otto, Rannikko, Antti, Kanerva, Anna, Tapper, Johanna, Hemminki, Akseli

“…Cytokines have proven to be effective for cancer therapy, however whilst low-dose monotherapy with cytokines provides limited therapeutic benefit, high-dose…”
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Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer by Kudling, Tatiana V., Clubb, James H.A., Pakola, Santeri, Quixabeira, Dafne C.A., Lähdeniemi, Iris A.K., Heiniö, Camilla, Arias, Victor, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao M., Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko I., Aaltonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W., Ilonen, Ilkka, Hemminki, Akseli

“…Lung cancer remains among the most difficult-to-treat malignancies and is the leading cause of cancer-related deaths worldwide. The introduction of targeted…”
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Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting by Clubb, James H A, Kudling, Tatiana V, Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C A, Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli

“…Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, but preclinical testing of hypotheses such as combination therapies has been…”
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