Search Results - "Heinemann, F S"

CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer by Wright, H J, Arulmoli, J, Motazedi, M, Nelson, L J, Heinemann, F S, Flanagan, L A, Razorenova, O V

“…Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic form of breast cancer that lacks the estrogen, progesterone and HER2 receptors and…”
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Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder by Schiffer, H.H., Heinemann, S.F.

“…The etiology of mood disorders remains elusive, despite our increasing understanding of the neurotransmitter systems and brain regions that are involved. We…”
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Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor by Xu, J, Cohen, B N, Zhu, Y, Dziewczapolski, G, Panda, S, Lester, H A, Heinemann, S F, Contractor, A

“…High-affinity nicotinic receptors containing β2 subunits (β2 * ) are widely expressed in the brain, modulating many neuronal processes and contributing to…”
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Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning by Wehner, J.M., Keller, J.J., Keller, A.B., Picciotto, M.R., Paylor, R., Booker, T.K., Beaudet, A., Heinemann, S.F., Balogh, S.A.

“…Nicotine can enhance contextual learning while ethanol impairs some forms of learning. Nicotine can overcome some of the impairing effects of ethanol when the…”
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Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems by Conn, P. J, Alagarsamy, S, Marino, M. J, Rouse, S. T, Gereau, R.W, Heinemann, S. F

“…The metabotropic glutamate receptor, mGluR5, has a critical role in induction of NMDA-receptor-dependent forms of synaptic plasticity and excitotoxicity. This…”
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Regional, Cellular, and Ultrastructural Distribution of N-Methyl-D- Aspartate Receptor Subunit 1 in Monkey Hippocampus by Siegel, S. J., Brose, N., Janssen, W. G., Gasic, G. P., Jahn, R., Heinemann, S. F., Morrison, J. H.

“…The regional, cellular, and subcellular distributions of N-methyl-D-aspartate (NMDA) receptor subunit 1, NMDAR-1, were investigated in monkey hippocampus by…”
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Ca2+Permeability of Unedited and Edited Versions of the Kainate Selective Glutamate Receptor GluR6 by Egebjerg, Jan, Heinemann, Stephen F.

“…The Ca2+permeability of the kainate selective glutamate receptor GluR6 depends on the editing of the RNA (or DNA). The unedited version of GluR6, GluR6Q,…”
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Identification of the Kainate Receptor Subunits Underlying Modulation of Excitatory Synaptic Transmission in the CA3 Region of the Hippocampus by Contractor, Anis, Swanson, Geoffrey T, Sailer, Andreas, O'Gorman, Stephen, Heinemann, Stephen F

“…To understand the physiological role of kainate receptors and their participation in seizure induction in animal models of epilepsy, it will be necessary to…”
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Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice by Heinemann, Stephen F, Mulle, Christophe, Sailer, Andreas, Pérez-Otaño, Isabel, Dickinson-Anson, Heather, Castillo, Pablo E, Bureau, Ingrid, Maron, Cornelia, Gage, Fred H, Mann, Jeffrey R, Bettler, Bernhard

“…l-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain, acts on three classes of ionotropic receptors: NMDA…”
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Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment by Marks, MJ, Pauly, JR, Gross, SD, Deneris, ES, Hermans-Borgmeyer, I, Heinemann, SF, Collins, AC

“…DBA mice were chronically treated with nicotine by continuous intravenous infusion of 4.0 mg/kg/hr for 10 d. Drug-treated mice were tolerant to the acute…”
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Control of Proton Sensitivity of the NMDA Receptor by RNA Splicing and Polyamines by Traynelis, Stephen F., Hartley, Melissa, Heinemann, Stephen F.

“…The function of the N-methyl-D-aspartate (NMDA)-preferring glutamate receptor can be regulated by extracellular pH, a process that may be important during…”
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Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit by Papke, R L, Heinemann, S F

“…As previously reported by Luetje and Patrick [J. Neurosci. 11:837-845 (1991)], the nicotine-like alkaloid cytisine is relatively ineffective in evoking current…”
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Alternative Splicing Generates Metabotropic Glutamate Receptors Inducing Different Patterns of Calcium Release in Xenopus oocytes by Pin, Jean-Philippe, Waeber, Christian, Prezeau, Laurent, Bockaert, Joel, Heinemann, Stephen F.

“…A splice variant of the metabotropic glutamate receptor (mGluR) 1a, named mGluR1c, was isolated. Compared to mGluR1a, the predicted mGluR1c protein is 302…”
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Autoantibodies to Glutamate Receptor GluR3 in Rasmussen's Encephalitis by Rogers, Scott W., Andrews, P. Ian, Gahring, Lorise C., Whisenand, Teri, Cauley, Keith, Crain, Barbara, Hughes, Thomas E., Heinemann, Stephen F., McNamara, James O.

“…Rasmussen's encephalitis is a progressive childhood disease of unknown cause characterized by severe epilepsy, hemiplegia, dementia, and inflammation of the…”
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Identification of a Site in Glutamate Receptor Subunits that Controls Calcium Permeability by Hume, Richard I., Dingledine, Raymond, Heinemann, Stephen F.

“…The neurotransmitter glutamate mediates excitatory synaptic transmission throughout the brain. A family of genes encoding subunits of the…”
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Domains involved in the specificity of G protein activation in phospholipase C‐coupled metabotropic glutamate receptors by Pin, J.P., Joly, C., Heinemann, S.F., Bockaert, J.

“…G protein‐coupled glutamate receptors (mGluR) have recently been characterized. These receptors have seven putative transmembrane domains, but display no…”
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Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior by Kolber, Benedict J, Montana, Michael C, Carrasquillo, Yarimar, Xu, Jian, Heinemann, Stephen F, Muglia, Louis J, Gereau, 4th, Robert W

“…The central nucleus of the amygdala (CeA) has been identified as a site of nociceptive processing important for sensitization induced by peripheral injury…”
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The Role of RNA Editing of Kainate Receptors in Synaptic Plasticity and Seizures by Vissel, B., Royle, G.A., Christie, B.R., Schiffer, H.H., Ghetti, A., Tritto, T., Perez-Otano, I., Radcliffe, R.A., Seamans, J., Sejnowski, T., Wehner, J.M., Collins, A.C., O'Gorman, S., Heinemann, S.F.

“…The ionotropic glutamate receptor subunit GluR6 undergoes developmentally and regionally regulated Q/R site RNA editing that reduces the calcium permeability…”
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Distribution and synaptic localization of immunocytochemically identified NMDA receptor subunit proteins in sensory-motor and visual cortices of monkey and human by Huntley, GW, Vickers, JC, Janssen, W, Brose, N, Heinemann, SF, Morrison, JH

“…NMDA receptors are composed of multiple receptor subunit proteins, of which NMDAR1 appears to be a critical component for normal receptor function (Nakanishi,…”
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Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey by Vickers, JC, Huntley, GW, Edwards, AM, Moran, T, Rogers, SW, Heinemann, SF, Morrison, JH

“…Excitatory amino acid transmission has been proposed as the principal synaptic mechanism for distribution of information through corticocortical and…”
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