Search Results - "Heinecke, Julie"

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression by Heinecke, Julie L., Ridnour, Lisa A., Cheng, Robert Y. S., Switzer, Christopher H., Lizardo, Michael M., Khanna, Chand, Glynn, Sharon A., Hussain, S. Perwez, Young, Howard A., Ambs, Stefan, Wink, David A.

“…Inflammation is widely recognized as an inducer of cancer progression. The inflammation-associated enzyme, inducible nitric oxide synthase (NOS2), has emerged…”
Get full text

Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression by Basudhar, Debashree, Somasundaram, Veena, de Oliveira, Graciele Almeida, Kesarwala, Aparna, Heinecke, Julie L, Cheng, Robert Y, Glynn, Sharon A, Ambs, Stefan, Wink, David A, Ridnour, Lisa A

“…Breast cancer is the second leading cause of cancer-related deaths among women in the United States. Development and progression of malignancy are associated…”
Get more information

Signaling and stress: The redox landscape in NOS2 biology by Thomas, Douglas D., Heinecke, Julie L., Ridnour, Lisa A., Cheng, Robert Y., Kesarwala, Aparna H., Switzer, Christopher H., McVicar, Daniel W., Roberts, David D., Glynn, Sharon, Fukuto, Jon M., Wink, David A., Miranda, Katrina M.

“…Nitric oxide (NO) has a highly diverse range of biological functions from physiological signaling and maintenance of homeostasis to serving as an effector…”
Get full text

Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity by Ridnour, Lisa A, Cheng, Robert Y S, Switzer, Christopher H, Heinecke, Julie L, Ambs, Stefan, Glynn, Sharon, Young, Howard A, Trinchieri, Giorgio, Wink, David A

“…Numerous reports have described Toll-like receptor (TLR) expression in the tumor microenvironment as it relates to cancer progression, as well as their…”
Get full text

Biological signaling by small inorganic molecules by Basudhar, Debashree, Ridnour, Lisa A., Cheng, Robert, Kesarwala, Aparna H., Heinecke, Julie, Wink, David A.

“…•Small inorganic molecules constitute an important class of signaling agent.•Regulated biosynthesis and kinetic constraints control signaling by these…”
Get full text

Nitrite Reduction Mediated by Heme Models. Routes to NO and HNO? by Heinecke, Julie L, Khin, Chosu, Pereira, Jose Clayston Melo, Suárez, Sebastián A, Iretskii, Alexei V, Doctorovich, Fabio, Ford, Peter C

“…The water-soluble ferriheme model FeIII(TPPS) mediates oxygen atom transfer from inorganic nitrite to a water-soluble phosphine (tppts), dimethyl sulfide, and…”
Get full text

Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation by Ridnour, Lisa A, Barasch, Kimberly M, Windhausen, Alisha N, Dorsey, Tiffany H, Lizardo, Michael M, Yfantis, Harris G, Lee, Dong H, Switzer, Christopher H, Cheng, Robert Y S, Heinecke, Julie L, Brueggemann, Ernst, Hines, Harry B, Khanna, Chand, Glynn, Sharon A, Ambs, Stefan, Wink, David A

“…Prediction of therapeutic response and cancer patient survival can be improved by the identification of molecular markers including tumor Akt status. A direct…”
Get full text

Synthesis and Chemical and Biological Comparison of Nitroxyl- and Nitric Oxide-Releasing Diazeniumdiolate-Based Aspirin Derivatives by Basudhar, Debashree, Bharadwaj, Gaurav, Cheng, Robert Y, Jain, Sarthak, Shi, Sa, Heinecke, Julie L, Holland, Ryan J, Ridnour, Lisa A, Caceres, Viviane M, Spadari-Bratfisch, Regina C, Paolocci, Nazareno, Velázquez-Martínez, Carlos A, Wink, David A, Miranda, Katrina M

“…Structural modifications of nonsteroidal anti-inflammatory drugs (NSAIDs) have successfully reduced the side effect of gastrointestinal ulceration without…”
Get full text

NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay by Ridnour, Lisa A, Cheng, Robert Y S, Weiss, Jonathan M, Kaur, Sukhbir, Soto-Pantoja, David R, Basudhar, Debashree, Heinecke, Julie L, Stewart, C Andrew, DeGraff, William, Sowers, Anastasia L, Thetford, Angela, Kesarwala, Aparna H, Roberts, David D, Young, Howard A, Mitchell, James B, Trinchieri, Giorgio, Wiltrout, Robert H, Wink, David A

“…Nitric oxide synthases (NOS) are important mediators of progrowth signaling in tumor cells, as they regulate angiogenesis, immune response, and immune-mediated…”
Get full text

Nitrite reduction by Co(II) and Mn(II) substituted myoglobins: towards understanding necessary components of Mb nitrite reductase activity by Heinecke, Julie L, Yi, Jun, Pereira, Jose Clayston Melo, Richter-Addo, George B, Ford, Peter C

“…Nitrite reduction to nitric oxide by heme proteins is drawing increasing attention as a protective mechanism to hypoxic injury in mammalian physiology. Here we…”
Get full text

Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways by Cheng, Robert Y.S., Basudhar, Debashree, Ridnour, Lisa A., Heinecke, Julie L., Kesarwala, Aparna H., Glynn, Sharon, Switzer, Christopher H., Ambs, Stefan, Miranda, Katrina M., Wink, David A.

“…•The biological effects of NO and HNO are governed by their cellular concentrations, plus spatial and temporal distribution both within tumor cells and in the…”
Get full text

Mechanistic studies of nitrite reactions with metalloproteins and models relevant to mammalian physiology by Heinecke, Julie, Ford, Peter C.

“…This review provides a summary of reaction mechanisms involving the interactions of nitrite ion with metal centers relevant to physiology. The majority of the…”
Get full text

Nitrite reduction by CoII and MnII substituted myoglobins by Heinecke, Julie L., Yi, Jun, Pereira, Jose Clayston Melo, Richter-Addo, George B., Ford, Peter C.

Get full text

The Distal Pocket Histidine Residue in Horse Heart Myoglobin Directs the O-Binding Mode of Nitrite to the Heme Iron by Yi, Jun, Heinecke, Julie, Tan, Hui, Ford, Peter C, Richter-Addo, George B

“…It is now well-established that mammalian heme proteins are reactive with various nitrogen oxide species and that these reactions may play significant roles in…”
Get full text

Formation of Cysteine Sulfenic Acid by Oxygen Atom Transfer from Nitrite by Heinecke, Julie, Ford, Peter C

“…Cysteine sulfenic acid CysS(O)H is shown to be formed for the reaction of cysteine (CysSH) with aqueous nitrite and the water-soluble ferriheme models…”
Get full text

Nitrite reduction by Co II and Mn II substituted myoglobins by Heinecke, Julie L., Yi, Jun, Pereira, Jose Clayston Melo, Richter-Addo, George B., Ford, Peter C.

“…Nitrite reduction to nitric oxide by heme proteins is drawing increasing attention as a protective mechanism to hypoxic injury in mammalian physiology. Here we…”
Get full text

P176 - Nitric oxide and breast cancer disease progression: Role of timp-1 in pro-survival signaling by Ridnour, Lisa, Glynn, Sharon, Barasch, Kim, Windhausen, Alisha, Sneha, Dhanapal, Dorsey, Tiffany, Yfantis, Harris, Lee, Dong H., Heinecke, Julie, Brueggemann, Ernie, Lizardo, Mike, Khanna, Chand, Ambs, Stephan, Wink, David, Hines, Harry, Switzer, Chris

Get full text

Nitric oxide and breast cancer disease progression: Role of timp-1 in pro-survival signaling by Ridnour, Lisa, Glynn, Sharon, Barasch, Kim, Windhausen, Alisha, Sneha, Dhanapal, Dorsey, Tiffany, Yfantis, Harris, Lee, Dong H., Heinecke, Julie, Brueggemann, Ernie, Lizardo, Mike, Khanna, Chand, Ambs, Stephan, Wink, David, Hines, Harry, Switzer, Chris

Get full text

Oxygen Atom Transfer from Nitrite Mediated by Fe(III) Porphyrins in Aqueous Solution by Khin, Chosu, Heinecke, Julie, Ford, Peter C

“…Aqueous solutions of the iron(III) porphyrin complex FeIII(TPPS) (1, TPPS = tetra(4-sulfonatophenyl)-porphyrinato) and nitrite ion react with various…”
Get full text

Luminescently Tagged 2,2‘-Bipyridine Complex of Fe II :  Synthesis and Photophysical Studies of 4-[ N -(2-Anthryl)carbamoyl]-4‘-methyl-2,2‘-bipyridine by Zigler, David F., Elvington, Mark C., Heinecke, Julie, Brewer, Karen J.

Get full text