Search Results - "Heine, Vivi M."

The involvement of astrocytes in early‐life adversity induced programming of the brain by Abbink, Maralinde R., Deijk, Anne‐Lieke F., Heine, Vivi M., Verheijen, Mark H., Korosi, Aniko

“…Early‐life adversity (ELA) in the form of stress, inflammation, or malnutrition, can increase the risk of developing psychopathology or cognitive problems in…”
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Conserved role of intragenic DNA methylation in regulating alternative promoters by Maunakea, Alika K., Nagarajan, Raman P., Bilenky, Mikhail, Ballinger, Tracy J., D’Souza, Cletus, Fouse, Shaun D., Johnson, Brett E., Hong, Chibo, Nielsen, Cydney, Zhao, Yongjun, Turecki, Gustavo, Delaney, Allen, Varhol, Richard, Thiessen, Nina, Shchors, Ksenya, Heine, Vivi M., Rowitch, David H., Xing, Xiaoyun, Fiore, Chris, Schillebeeckx, Maximiliaan, Jones, Steven J. M., Haussler, David, Marra, Marco A., Hirst, Martin, Wang, Ting, Costello, Joseph F.

“…Methylation in the genes DNA methylation plays an important role in the maintenance of cell identity through its effect on gene expression. Methylation of 5′…”
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Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation by Alsaqati, Mouhamed, Heine, Vivi M, Harwood, Adrian J

“…Abstract Background Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder resulting from autosomal dominant mutations in the TSC1 or TSC2…”
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Astrocytes are central in the pathomechanisms of vanishing white matter by Dooves, Stephanie, Bugiani, Marianna, Postma, Nienke L, Polder, Emiel, Land, Niels, Horan, Stephen T, van Deijk, Anne-Lieke F, van de Kreeke, Aleid, Jacobs, Gerbren, Vuong, Caroline, Klooster, Jan, Kamermans, Maarten, Wortel, Joke, Loos, Maarten, Wisse, Lisanne E, Scheper, Gert C, Abbink, Truus E M, Heine, Vivi M, van der Knaap, Marjo S

“…Vanishing white matter (VWM) is a fatal leukodystrophy that is caused by mutations in genes encoding subunits of eukaryotic translation initiation factor 2B…”
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KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients by Hinz, Lisa, Torrella Barrufet, Joan, Heine, Vivi M

“…Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K -Cl co-transporter 2…”
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Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models by Nadadhur, Aishwarya G., Alsaqati, Mouhamed, Gasparotto, Lisa, Cornelissen-Steijger, Paulien, van Hugte, Eline, Dooves, Stephanie, Harwood, Adrian J., Heine, Vivi M.

“…Tuberous sclerosis complex (TSC) is a rare neurodevelopmental disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes, leading to a…”
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Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma by Schüller, Ulrich, Heine, Vivi M., Mao, Junhao, Kho, Alvin T., Dillon, Allison K., Han, Young-Goo, Huillard, Emmanuelle, Sun, Tao, Ligon, Azra H., Qian, Ying, Ma, Qiufu, Alvarez-Buylla, Arturo, McMahon, Andrew P., Rowitch, David H., Ligon, Keith L.

“…Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor cells is unclear. To investigate this, we activated oncogenic…”
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In Vitro Modelling of Osteogenesis Imperfecta with Patient-Derived Induced Mesenchymal Stem Cells by Claeys, Lauria, Zhytnik, Lidiia, Ventura, Laura, Wisse, Lisanne E, Eekhoff, Elisabeth M W, Pals, Gerard, Bravenboer, Nathalie, Heine, Vivi M, Micha, Dimitra

“…(1) Mesenchymal stem cells (MSCs) are a valuable cell model to study the bone pathology of Osteogenesis Imperfecta (OI), a rare genetic collagen-related…”
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Genetically-Informed Patient Selection for iPSC Studies of Complex Diseases May Aid in Reducing Cellular Heterogeneity by Hoekstra, Stephanie D, Stringer, Sven, Heine, Vivi M, Posthuma, Danielle

“…Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability,…”
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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade by Hyman, Joel M, Firestone, Ari J, Heine, Vivi M, Zhao, Yun, Ocasio, Cory A, Han, Kyuho, Sun, Mark, Rack, Paul G, Sinha, Surajit, Wu, Jason J, Solow-Cordero, David E, Jiang, Jin, Rowitch, David H, Chen, James K

“…Inappropriate activation of the Hedgehog (Hh) signaling pathway has been implicated in a diverse spectrum of cancers, and its pharmacological blockade has…”
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Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter by Leferink, Prisca S., Breeuwsma, Nicole, Bugiani, Marianna, van der Knaap, Marjo S., Heine, Vivi M.

“…Leukodystrophies are often devastating diseases, presented with progressive clinical signs as spasticity, ataxia and cognitive decline, and lack proper…”
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Engineered cell culture microenvironments for mechanobiology studies of brain neural cells by Castillo Ransanz, Lucía, Van Altena, Pieter F J, Heine, Vivi M, Accardo, Angelo

“…The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are…”
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Comparison of Mouse and Human Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related Macular Degeneration by Bennis, Anna, Gorgels, Theo G M F, Ten Brink, Jacoline B, van der Spek, Peter J, Bossers, Koen, Heine, Vivi M, Bergen, Arthur A

“…The human retinal pigment epithelium (RPE) plays an important role in the pathogenesis of age related macular degeneration (AMD). AMD is the leading cause of…”
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Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells by Nadadhur, Aishwarya G, Emperador Melero, Javier, Meijer, Marieke, Schut, Desiree, Jacobs, Gerbren, Li, Ka Wan, Hjorth, J J Johannes, Meredith, Rhiannon M, Toonen, Ruud F, Van Kesteren, Ronald E, Smit, August B, Verhage, Matthijs, Heine, Vivi M

“…Generation of neuronal cultures from induced pluripotent stem cells (hiPSCs) serve the studies of human brain disorders. However we lack neuronal networks with…”
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A 3D human co-culture to model neuron-astrocyte interactions in tauopathies by Batenburg, Kevin L, Sestito, Claudia, Cornelissen-Steijger, Paulien, van Weering, Jan R T, Price, Leo S, Heine, Vivi M, Scheper, Wiep

“…Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also…”
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Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors by Varderidou-Minasian, Suzy, Hinz, Lisa, Hagemans, Dominique, Posthuma, Danielle, Altelaar, Maarten, Heine, Vivi M

“…Rett syndrome (RTT) is a progressive neurodevelopmental disease that is characterized by abnormalities in cognitive, social, and motor skills. RTT is often…”
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Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro by Nadadhur, Aishwarya G., Leferink, Prisca S., Holmes, Dwayne, Hinz, Lisa, Cornelissen-Steijger, Paulien, Gasparotto, Lisa, Heine, Vivi M.

“…The neural tube consists of neural progenitors (NPs) that acquire different characteristics during gestation due to patterning factors. However, the influence…”
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Neuron-Glia Interactions in Tuberous Sclerosis Complex Affect the Synaptic Balance in 2D and Organoid Cultures by Dooves, Stephanie, van Velthoven, Arianne J H, Suciati, Linda G, Heine, Vivi M

“…Tuberous sclerosis complex (TSC) is a genetic disease affecting the brain. Neurological symptoms like epilepsy and neurodevelopmental issues cause a…”
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Comparative gene expression study and pathway analysis of the human iris- and the retinal pigment epithelium by Bennis, Anna, Ten Brink, Jacoline B, Moerland, Perry D, Heine, Vivi M, Bergen, Arthur A

“…The retinal pigment epithelium (RPE) is a neural monolayer lining the back of the eye. Degeneration of the RPE leads to severe vision loss in, so far…”
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Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain by Silbereis, John C, Nobuta, Hiroko, Tsai, Hui-Hsin, Heine, Vivi M, McKinsey, Gabriel L, Meijer, Dimphna H, Howard, Mackenzie A, Petryniak, Magda A, Potter, Gregory B, Alberta, John A, Baraban, Scott C, Stiles, Charles D, Rubenstein, John L R, Rowitch, David H

“…Abnormal GABAergic interneuron density, and imbalance of excitatory versus inhibitory tone, is thought to result in epilepsy, neurodevelopmental disorders, and…”
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