Search Results - "Heindryckx, B."

Chromosomal mosaicism in human blastocysts: the ultimate challenge of preimplantation genetic testing? by Popovic, M, Dheedene, A, Christodoulou, C, Taelman, J, Dhaenens, L, Van Nieuwerburgh, F, Deforce, D, Van den Abbeel, E, De Sutter, P, Menten, B, Heindryckx, B

“…Abstract STUDY QUESTION To what extent does a trophectoderm (TE) biopsy reliably reflect the chromosomal constitution of the inner cell mass (ICM) in human…”
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Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy by Popovic, M, Dhaenens, L, Taelman, J, Dheedene, A, Bialecka, M, De Sutter, P, Chuva de Sousa Lopes, S M, Menten, B, Heindryckx, B

“…Abstract STUDY QUESTION What is the accuracy of preimplantation genetic testing for aneuploidies (PGT-A) when considering human peri-implantation outcomes in…”
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Oocyte activation, phospholipase C zeta and human infertility by Kashir, J., Heindryckx, B., Jones, C., De Sutter, P., Parrington, J., Coward, K.

“…BACKGROUND Mammalian oocytes are activated by intracellular calcium (Ca2+) oscillations following gamete fusion. Recent evidence implicates a sperm-specific…”
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Genome engineering through CRISPR/Cas9 technology in the human germline and pluripotent stem cells by Vassena, R, Heindryckx, B, Peco, R, Pennings, G, Raya, A, Sermon, K, Veiga, A

“…With the recent development of CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome editing technology, the possibility to…”
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CRISPR/Cas gene editing in the human germline by Bekaert, B., Boel, A., Cosemans, G., De Witte, L., Menten, B., Heindryckx, B.

“…The ease and efficacy of CRISPR/Cas9 germline gene editing in animal models paved the way to human germline gene editing (HGGE), by which permanent changes can…”
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Human in vitro spermatogenesis from pluripotent stem cells: in need of a stepwise differentiation protocol? by Rombaut, C, Mertes, H, Heindryckx, B, Goossens, E

“…Abstract Recently, complete in vitro generation of male gametes starting from pluripotent stem cells was obtained in a mouse model with live offspring as a…”
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SPERM FACTORS AND EGG ACTIVATION: Fertilization failure after human ICSI and the clinical potential of PLCZ1 by Cardona Barberán, A, Boel, A, Vanden Meerschaut, F, Stoop, D, Heindryckx, B

“…Two decades have passed since the discovery of phospholipase C zeta (PLCZ1) as the sperm oocyte-activating factor. At present, there is a general consensus…”
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Direct comparison of distinct naive pluripotent states in human embryonic stem cells by Warrier, S., Van der Jeught, M., Duggal, G., Tilleman, L., Sutherland, E., Taelman, J., Popovic, M., Lierman, S., Chuva De Sousa Lopes, S., Van Soom, A., Peelman, L., Van Nieuwerburgh, F., De Coninck, D. I. M., Menten, B., Mestdagh, P., Van de Sompele, J., Deforce, D., De Sutter, P., Heindryckx, B.

“…Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a…”
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TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo by Stamatiadis, P, Cosemans, G, Boel, A, Menten, B, De Sutter, P, Stoop, D, Chuva de Sousa Lopes, S M, Lluis, F, Coucke, P, Heindryckx, B

“…What is the role of transcriptional-enhanced associate (TEA) domain family member 4 (TEAD4) in trophectoderm (TE) differentiation during human embryo…”
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A new advanced stem cell-based embryonic model: The ultimate model? by Declercq, S., Chuva de Sousa Lopes, S.M., Heindryckx, B.

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Human oocyte calcium analysis predicts the response to assisted oocyte activation in patients experiencing fertilization failure after ICSI by Ferrer-Buitrago, M, Dhaenens, L, Lu, Y, Bonte, D, Vanden Meerschaut, F, De Sutter, P, Leybaert, L, Heindryckx, B

“…Abstract STUDY QUESTION Can human oocyte calcium analysis predict fertilization success after assisted oocyte activation (AOA) in patients experiencing…”
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Assisted oocyte activation does not overcome recurrent embryo developmental problems by Cardona Barberán, A, Bonte, D, Boel, A, Thys, V, Paredis, R, Machtelinckx, F, De Sutter, P, De Croo, I, Leybaert, L, Stoop, D, Coucke, P, Vanden Meerschaut, F, Heindryckx, B

“…Abstract STUDY QUESTION Can recurrent embryo developmental problems after ICSI be overcome by assisted oocyte activation (AOA)? SUMMARY ANSWER AOA did not…”
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Characterization of ovarian tissue oocytes from transgender men reveals poor calcium release and embryo development, which might be overcome by spindle transfer by Christodoulaki, A, He, H, Zhou, M, Cardona Barberán, A, De Roo, C, Chuva De Sousa Lopes, S M, Baetens, M, Menten, B, Van Soom, A, De Sutter, P, Weyers, S, Boel, A, Stoop, D, Heindryckx, B

“…Can spindle transfer (ST) overcome inferior embryonic development of in vitro matured ovarian tissue oocytes (OTO-IVM) originating from testosterone-treated…”
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Diagnostic and prognostic value of calcium oscillatory pattern analysis for patients with ICSI fertilization failure by Vanden Meerschaut, F., Leybaert, L., Nikiforaki, D., Qian, C., Heindryckx, B., De Sutter, P.

“…STUDY QUESTION Does calcium oscillatory pattern analysis following heterologous intra-cytoplasmic sperm injection (ICSI) of human sperm into mouse oocytes lead…”
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Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest by Tang, M, Popovic, M, Stamatiadis, P, Van der Jeught, M, Van Coster, R, Deforce, D, De Sutter, P, Coucke, P, Menten, B, Stoop, D, Boel, A, Heindryckx, B

“…Abstract STUDY QUESTION Can pronuclear transfer (PNT) or maternal spindle transfer (ST) be applied to overcome poor embryo development associated with advanced…”
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Comparative analysis of mouse and human preimplantation development following POU5F1 CRISPR/Cas9 targeting reveals interspecies differences by Stamatiadis, P, Boel, A, Cosemans, G, Popovic, M, Bekaert, B, Guggilla, R, Tang, M, De Sutter, P, Van Nieuwerburgh, F, Menten, B, Stoop, D, Chuva de Sousa Lopes, S M, Coucke, P, Heindryckx, B

“…What is the role of POU class 5 homeobox 1 (POU5F1) in human preimplantation development and how does it compare with the mouse model? POU5F1 is required for…”
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Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI by Heindryckx, B., Van der Elst, J., De Sutter, P., Dhont, M.

“…BACKGROUND: Failed fertilization occurs in 2–3% of ICSI cycles and is mainly due to lack of oocyte activation. Heterologous ICSI of patient's sperm in mouse…”
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Two decades of embryonic stem cells: a historical overview by Eguizabal, C, Aran, B, Chuva de Sousa Lopes, S M, Geens, M, Heindryckx, B, Panula, S, Popovic, M, Vassena, R, Veiga, A

“…Abstract STUDY QUESTION How did the field of stem cell research develop in the years following the derivation of the first human embryonic stem cell (hESC)…”
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Stem cells in reproductive medicine: ready for the patient? by Vassena, R., Eguizabal, C., Heindryckx, B., Sermon, K., Simon, C., van Pelt, A.M.M., Veiga, A., Zambelli, F.

“…STUDY QUESTION Are there effective and clinically validated stem cell-based therapies for reproductive diseases? SUMMARY ANSWER At the moment, clinically…”
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Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model by Ferrer-Buitrago, M, Tilleman, L, Thys, V, Hachem, A, Boel, A, Van Nieuwerburgh, F, Deforce, D, Leybaert, L, De Sutter, P, Parrington, J, Heindryckx, B

“…Abstract Mammalian fertilization encompasses a series of Ca2+ oscillations initiated by the sperm factor phospholipase C zeta (PLCζ). Some studies have shown…”
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