Search Results - "Heimlich, J."

Somatic Mutations in Cardiovascular Disease by Heimlich, J. Brett, Bick, Alexander G.

“…Advances in population-scale genomic sequencing have greatly expanded the understanding of the inherited basis of cardiovascular disease (CVD). Reanalysis of…”
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Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank by Vlasschaert, Caitlyn, Heimlich, J. Brett, Rauh, Michael J., Natarajan, Pradeep, Bick, Alexander G.

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A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets by Vlasschaert, Caitlyn, Mack, Taralynn, Heimlich, J. Brett, Niroula, Abhishek, Uddin, Md Mesbah, Weinstock, Joshua, Sharber, Brian, Silver, Alexander J., Xu, Yaomin, Savona, Michael, Gibson, Christopher, Lanktree, Matthew B., Rauh, Michael J., Ebert, Benjamin L., Natarajan, Pradeep, Jaiswal, Siddhartha, Bick, Alexander G.

“…•We present a practical method to ascertain CHIP that combines sequence-based and population-based filtering in the UK Biobank and All of Us.•Small changes in…”
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Endothelin‐1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species by Brett Heimlich, J, Speed, Joshua S, O'Connor, Paul M, Pollock, Jennifer S, Townes, Tim M, Meiler, Steffen E, Kutlar, Abdullah, Pollock, David M

“…Background and Purpose Endothelin‐1 (ET‐1) is increased in patients with sickle cell disease and may contribute to the development of sickle cell nephropathy…”
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Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk by Yu, Zhi, Fidler, Trevor P, Ruan, Yunfeng, Vlasschaert, Caitlyn, Nakao, Tetsushi, Uddin, Md Mesbah, Mack, Taralynn, Niroula, Abhishek, Heimlich, J Brett, Zekavat, Seyedeh M, Gibson, Christopher J, Griffin, Gabriel K, Wang, Yuxuan, Peloso, Gina M, Heard-Costa, Nancy, Levy, Daniel, Vasan, Ramachandran S, Aguet, François, Ardlie, Kristin G, Taylor, Kent D, Rich, Stephen S, Rotter, Jerome I, Libby, Peter, Jaiswal, Siddhartha, Ebert, Benjamin L, Bick, Alexander G, Tall, Alan R, Natarajan, Pradeep

“…Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome…”
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Using a Delphi study to clarify the landscape and core outcomes in environmental education by Clark, C. R., Heimlich, J. E., Ardoin, N. M., Braus, J.

“…When leaders in a field agree upon core outcomes for the field, connection, reinforcement, and a shared vision of change are synergistically strengthened. Even…”
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Programmable droplets: Leveraging digitally-responsive flow fields to actively tune liquid morphologies by Kay, Raphael, Katrycz, Charlie W, Heimlich, Ethan J, Hatton, Benjamin D

“…Stimulus-responsive materials enable programmable and adaptive behaviors. Typical solid-phase systems can only achieve small deformations for applications…”
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Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics by Mack, Taralynn, Vlasschaert, Caitlyn, von Beck, Kelly, Silver, Alexander J., Heimlich, J. Brett, Poisner, Hannah, Condon, Henry R., Ulloa, Jessica, Sochacki, Andrew L., Spaulding, Travis P., Kishtagari, Ashwin, Bejan, Cosmin A., Xu, Yaomin, Savona, Michael R., Jones, Angela, Bick, Alexander G.

“…Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related phenomenon in which hematopoietic stem cells acquire mutations in a select set…”
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ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus by Heimlich, J. B., Speed, J. S., Bloom, C. J., O'Connor, P. M., Pollock, J. S., Pollock, D. M.

“…Aim This study was designed to determine whether ET‐1 derived from endothelial cells contributes to oxidative stress in the glomerulus of mice subjected to a…”
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Reversible, regional ST‐segment elevation due to chylothorax by Brown, Sarah H., Neuss, Michael J., Heimlich, J. Brett, Kronenberg, Marvin W.

“…Chylothorax is an uncommon complication of thoracic surgery and, to our knowledge, has never been documented as a cause of dynamic ST‐segment elevation (STE)…”
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Endothelin‐1 as a master regulator of whole‐body Na+ homeostasis by Speed, Joshua S., Heimlich, J. Brett, Hyndman, Kelly A., Fox, Brandon M., Patel, Vivek, Yanagisawa, Masashi, Pollock, Jennifer S., Titze, Jens M., Pollock, David M.

“…ABSTRACT The current study was designed to determine whether vascular endothelial‐derived endothelin‐1 (ET‐1) is important for skin Na+ buffering. In control…”
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Real‐world experience using hydroxyurea in children with sickle cell disease in Lilongwe, Malawi by Mvalo, Tisungane, Topazian, Hillary M., Kamthunzi, Portia, Chen, Jane S., Kambalame, Isobel, Mafunga, Pilirani, Mumba, Noel, Chiume, Msandeni, Paseli, Khadija, Tegha, Gerald, Kumwenda, Wiza, Heimlich, J. Brett, Ellis, Graham, Key, Nigel, Gopal, Satish, Hoffman, Irving, Ataga, Kenneth I., Westmoreland, Kate D.

“…Introduction Sickle cell disease (SCD) is among the most common inherited hematologic diseases in sub‐Saharan Africa (SSA). Historically, hydroxyurea…”
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Nephrin as a biomarker of sickle cell glomerulopathy in Malawi by Heimlich, J. Brett, Chipoka, Godwin, Elsherif, Laila, David, Emeraghi, Ellis, Graham, Kamthunzi, Portia, Krysiak, Robert, Mafunga, Pilirani, Zhou, Qingning, Cai, Jianwen, Gopal, Satish, Key, Nigel S., Ataga, Kenneth I.

“…Background Glomerulopathy is an increasingly identified complication in young patients with sickle cell disease (SCD). Hyperfiltration and albuminuria followed…”
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Establishing sickle cell diagnostics and characterizing a paediatric sickle cell disease cohort in Malawi by Heimlich, J. Brett, Chipoka, Godwin, Kamthunzi, Portia, Krysiak, Robert, Majawa, Yacinta, Mafunga, Pilirani, Fedoriw, Yuri, Phiri, Ajib, Key, Nigel S., Ataga, Kenneth I., Gopal, Satish

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Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential by Heimlich, J Brett, Raddatz, Michael A, Wells, John, Vlasschaert, Caitlyn, Olson, Sydney, Threadcraft, Marcus, Foster, Kristoff, Boateng, Emmanuel, Umbarger, Kelsey, Su, Yan Ru, Roden, Dan M, Barker, Colin M, Bick, Alexander G

“…Clonal hematopoiesis of indeterminate potential (CHIP) occurs due to acquired mutations in bone marrow progenitor cells. CHIP confers a 2-fold risk of…”
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Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation by Heimlich, J. Brett, Bhat, Pawan, Parker, Alyssa C., Jenkins, Matthew T., Vlasschaert, Caitlyn, Ulloa, Jessica, Van Amburg, Joseph C., Potts, Chad R., Olson, Sydney, Silver, Alexander J., Ahmad, Ayesha, Sharber, Brian, Brown, Donovan, Hu, Ningning, van Galen, Peter, Savona, Michael R., Bick, Alexander G., Ferrell, P. Brent

“…•CD14+ monocytes from patients with CH stimulate inflammation through increased cytokine expression.•T cells from CH are deficient in GIMAP expression,…”
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Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository by Shannon, Morgan L., Heimlich, J. Brett, Olson, Sydney, Debevec, Ariana, Copeland, Zachary, Kishtagari, Ashwin, Vlasschaert, Caitlyn, Snider, Christina, Silver, Alexander J., Brown, Donovan, Spaulding, Travis, Bhatta, Manasa, Pugh, Kelly, Stockton, Shannon S., Ulloa, Jessica, Xu, Yaomin, Baljevic, Muhamed, Moslehi, Javid, Jahangir, Eiman, Ferrell, P. Brent, Slosky, David, Bick, Alexander G., Savona, Michael R.

“…•Development of a genotyped and phenotyped cohort of patients with CH is required to establish clinical guidelines and translational research.•Initial data…”
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Development of sickle cell diagnostics and a pediatric sickle cell clinic in Malawi by Kamthunzi, Portia, Topazian, Hillary, Mvalo, Tisungane, Chen, Jane, Kambalame, Isobel, Mafunga, Pilirani, Mumba, Noel, Chiume, Msandeni, Paseli, Khadija, Heimlich, J. Brett, Ellis, Graham, Key, Nigel, Gopal, Satish, Hoffman, Irving, Ataga, Ken, Westmoreland, Kate

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Variable reactive hyperemia in normotensive strains of rat by Heimlich, J. Brett, Pollock, David M.

“…Previous studies from our laboratory report variation in nitric oxide (NO)‐dependent arterial pressure within the same strain of normotensive Sprague–Dawley…”
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Prototype tests for a DIRC detector for the WASA-at-COSY experiment by Adolph, Ch, Eyrich, W., Jaus, J., Heimlich, J., Schmidt, A., Teufel, A., Ulbrich, K., Vogel, C.

“…The WASA-at-COSY experiment allows the study of production and decay of η and η ′ mesons in proton–proton reactions. At the moment the Forward Range Hodoscope…”
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