Search Results - "Heimbach, André"

Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum by Zillich, Lea, Poisel, Eric, Frank, Josef, Foo, Jerome C., Friske, Marion M., Streit, Fabian, Sirignano, Lea, Heilmann-Heimbach, Stefanie, Heimbach, André, Hoffmann, Per, Degenhardt, Franziska, Hansson, Anita C., Bakalkin, Georgy, Nöthen, Markus M., Rietschel, Marcella, Spanagel, Rainer, Witt, Stephanie H.

“…Alcohol Use Disorder (AUD) is a major contributor to global mortality and morbidity. Postmortem human brain tissue enables the investigation of molecular…”
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The severity of human peri‐implantitis lesions correlates with the level of submucosal microbial dysbiosis by Kröger, Annika, Hülsmann, Claudia, Fickl, Stefan, Spinell, Thomas, Hüttig, Fabian, Kaufmann, Frederic, Heimbach, André, Hoffmann, Per, Enkling, Norbert, Renvert, Stefan, Schwarz, Frank, Demmer, Ryan T., Papapanou, Panos N., Jepsen, Søren, Kebschull, Moritz

“…Aim To cross‐sectionally analyse the submucosal microbiome of peri‐implantitis (PI) lesions at different severity levels. Materials and Methods Microbial…”
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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2 , encoding a lysosomal type 5 P-type ATPase by Al-Din, Amir, Hillmer, Axel M, Gründemann, Jan, Goebel, Ingrid, Woods, C Geoffrey, Stiller, Barbara, Wriekat, Abdul-Latif, Heimbach, André, Mubaidin, Ammar F, Behrens, Maria I, Cid, L Pablo, Karsak, Meliha, Ramirez, Alfredo, Kubisch, Christian, Liss, Birgit, Hampshire, Dan, Roeper, Jochen

“…Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and…”
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F8 Inversions at Xq28 Causing Hemophilia A Are Associated With Specific Methylation Changes: Implication for Molecular Epigenetic Diagnosis by Jamil, Muhammad Ahmer, Sharma, Amit, Nuesgen, Nicole, Pezeshkpoor, Behnaz, Heimbach, André, Pavlova, Anne, Oldenburg, Johannes, El-Maarri, Osman

“…Diverse DNA structural variations (SVs) in human cancers and several other diseases are well documented. For genomic inversions in particular, the disease…”
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Sensitivity and specificity of loss of heterozygosity analysis for the classification of rare germline variants in BRCA1/2 : results of the observational AGO-TR1 study (NCT02222883) by Hauke, Jan, Harter, Philipp, Ernst, Corinna, Burges, Alexander, Schmidt, Sandra, Reuss, Alexander, Borde, Julika, De Gregorio, Nikolaus, Dietrich, Dimo, El-Balat, Ahmed, Kayali, Mohamad, Gevensleben, Heidrun, Hilpert, Felix, Altmüller, Janine, Heimbach, André, Meier, Werner, Schoemig-Markiefka, Birgid, Thiele, Holger, Kimmig, Rainer, Nürnberg, Peter, Kast, Karin, Richters, Lisa, Sehouli, Jalid, Schmutzler, Rita K, Hahnen, Eric

“…Variant-specific loss of heterozygosity (LOH) analyses may be useful to classify germline variants of unknown significance (VUS). The sensitivity and…”
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Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism by Park, Jin-Sung, Mehta, Prachi, Cooper, Antony A., Veivers, David, Heimbach, André, Stiller, Barbara, Kubisch, Christian, Fung, Victor S., Krainc, Dimitri, Mackay-Sim, Alan, Sue, Carolyn M.

“…Kufor‐Rakeb syndrome (KRS) is a rare form of autosomal recessive juvenile or early‐onset, levodopa responsive parkinsonism and has been associated with…”
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A Resilience Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice by Vennin, Constance, Hewel, Charlotte, Todorov, Hristo, Wendelmuth, Marlon, Radyushkin, Konstantin, Heimbach, André, Horenko, Illia, Ayash, Sarah, Müller, Marianne B, Schweiger, Susann, Gerber, Susanne, Lutz, Beat

“…Upon chronic stress, a fraction of individuals shows stress resilience, which can prevent long-term mental dysfunction. The underlying molecular mechanisms are…”
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Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly by Domingues, Francisco S., König, Eva, Schwienbacher, Christine, Volpato, Claudia B., Picard, Anne, Cantaloni, Chiara, Mascalzoni, Deborah, Lackner, Peter, Heimbach, André, Hoffmann, Per, Stanzial, Franco, Hicks, Andrew A., Parmeggiani, Lucio, Benedicenti, Francesco, Pellegrin, Serena, Casara, Gianluca, Pramstaller, Peter P.

“…Mutations in SZT2 have been previously reported in several cases of early onset epilepsy and intellectual disability. In this study we investigate potential…”
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CHD1L: a new candidate gene for congenital anomalies of the kidneys and urinary tract (CAKUT) by BROCKSCHMIDT, Antje, CHUN, Boidinh, KONRAD, Martin, WINYARD, Paul, HAFFNER, Dieter, SCHAEFER, Franz, WEBER, Ruthild G, WEBER, Stefanie, FISCHER, Dagmar-Christiane, KOLATSI-JOANNOU, Maria, CHRIST, Laura, HEIMBACH, Andre, SHTIZA, Diamant, KLAUS, Günter, SIMONETTI, Giacomo D

“…Recently, we identified a microduplication in chromosomal band 1q21.1 encompassing the CHD1L/ALC1 gene encoding a chromatin-remodelling enzyme in congenital…”
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Prevalence of deleterious germline variants in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1) by Harter, Philipp, Hauke, Jan, Heitz, Florian, Reuss, Alexander, Kommoss, Stefan, Marmé, Frederik, Heimbach, André, Prieske, Katharina, Richters, Lisa, Burges, Alexander, Neidhardt, Guido, de Gregorio, Nikolaus, El-Balat, Ahmed, Hilpert, Felix, Meier, Werner, Kimmig, Rainer, Kast, Karin, Sehouli, Jalid, Baumann, Klaus, Jackisch, Christian, Park-Simon, Tjoung-Won, Hanker, Lars, Kröber, Sandra, Pfisterer, Jacobus, Gevensleben, Heidrun, Schnelzer, Andreas, Dietrich, Dimo, Neunhöffer, Tanja, Krockenberger, Mathias, Brucker, Sara Y, Nürnberg, Peter, Thiele, Holger, Altmüller, Janine, Lamla, Josefin, Elser, Gabriele, du Bois, Andreas, Hahnen, Eric, Schmutzler, Rita

“…Identification of families at risk for ovarian cancer offers the opportunity to consider prophylactic surgery thus reducing ovarian cancer mortality. So far,…”
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Investigation of Cell-Contact Dependent Alterations in Immune Synapse Formation between T Cells and BCP-ALL Cells by Wenske, Britta, Marischen, Lothar, Welzenbach, Julia, Heimbach, André, Hoffmann, Per, Corbacioglu, Selim, Williams, David A, Troeger, Anja

“…Cancer-development is often associated with a state of immune attenuation and impaired antigen-recognition, contributing to the failure of immune surveillance…”
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Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Clusters Based on Integrated Genomic Surveillance, Outbreak Analysis and Contact Tracing in an Urban Setting by Walker, Andreas, Houwaart, Torsten, Finzer, Patrick, Ehlkes, Lutz, Tyshaieva, Alona, Damagnez, Maximilian, Strelow, Daniel, Duplessis, Ashley, Nicolai, Jessica, Wienemann, Tobias, Tamayo, Teresa, Kohns Vasconcelos, Malte, Hülse, Lisanna, Hoffmann, Katrin, Lübke, Nadine, Hauka, Sandra, Andree, Marcel, Däumer, Martin P, Thielen, Alexander, Kolbe-Busch, Susanne, Göbels, Klaus, Zotz, Rainer, Pfeffer, Klaus, Timm, Jörg, Dilthey, Alexander T

“…Abstract Background Tracing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission chains is still a major challenge for public health…”
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Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021 by Houwaart, Torsten, Belhaj, Samir, Tawalbeh, Emran, Nagels, Dirk, Fröhlich, Yara, Finzer, Patrick, Ciruela, Pilar, Sabrià, Aurora, Herrero, Mercè, Andrés, Cristina, Antón, Andrés, Benmoumene, Assia, Asskali, Dounia, Haidar, Hussein, von Dahlen, Janina, Nicolai, Jessica, Stiller, Mygg, Blum, Jacqueline, Lange, Christian, Adelmann, Carla, Schroer, Britta, Osmers, Ute, Grice, Christiane, Kirfel, Phillipp P., Jomaa, Hassan, Strelow, Daniel, Hülse, Lisanna, Pigulla, Moritz, Kreuzer, Pascal, Tyshaieva, Alona, Weber, Jonas, Wienemann, Tobias, Kohns Vasconcelos, Malte, Hoffmann, Katrin, Lübke, Nadine, Hauka, Sandra, Andree, Marcel, Scholz, Claus Jürgen, Jazmati, Nathalie, Göbels, Klaus, Zotz, Rainer, Pfeffer, Klaus, Timm, Jörg, Ehlkes, Lutz, Walker, Andreas, Dilthey, Alexander T.

“…Background Tracking person-to-person SARS-CoV-2 transmission in the population is important to understand the epidemiology of community transmission and may…”
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BRCA -like classification in ovarian cancer: Results from the AGO-TR1-trial by Richters, Lisa Katharina, Schouten, Philip C., Kommoss, Stefan, Hauke, Jan, Burges, Alexander, Dietrich, Dimo, El-Balat, Ahmed, Hilpert, Felix, Kluin, Roel, Heubner, Martin Leonhard, Kast, Karin, Heimbach, André, Braicu, Elena Ioana, Schmidt, Sandra, Baumann, Klaus H., Jackisch, Christian, Linn, Sabine C., Schmutzler, Rita K., Harter, Philipp, Hahnen, Eric

“…Abstract only 5546 Background: BRCA associated cancers show a distinct pattern of genomic gains and losses that is associated with impaired repair of DNA…”
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Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores by Ishorst, Nina, Henschel, Leonie, Thieme, Frederic, Drichel, Dmitriy, Sivalingam, Sugirthan, Mehrem, Sarah L., Fechtner, Ariane C., Fazaal, Julia, Welzenbach, Julia, Heimbach, André, Maj, Carlo, Borisov, Oleg, Hausen, Jonas, Raff, Ruth, Hoischen, Alexander, Dixon, Michael, Rada‐Iglesias, Alvaro, Bartusel, Michaela, Rojas‐Martinez, Augusto, Aldhorae, Khalid, Braumann, Bert, Kruse, Teresa, Kirschneck, Christian, Spanier, Gerrit, Reutter, Heiko, Nowak, Stefanie, Gölz, Lina, Knapp, Michael, Buness, Andreas, Krawitz, Peter, Nöthen, Markus M., Nothnagel, Michael, Becker, Tim, Ludwig, Kerstin U., Mangold, Elisabeth

“…Background Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40…”
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Next-generation sequencing in BRCA1/2 -negative breast and ovarian cancer families by Hauke, Jan, Heimbach, Andre, Richters, Lisa Katharina, Kroeber, Sandra, Altmüller, Janine, Thiele, Holger, Nuernberg, Peter, Wappenschmidt, Barbara, Neidhardt, Guido, Rhiem, Kerstin, Schmutzler, Rita K., Hahnen, Eric

“…Abstract only…”
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Incidence of germline mutations in risk genes including BRCA1/2 in consecutive ovarian cancer (OC) patients (AGO TR-1) by Harter, Philipp, Hauke, Jan, Heitz, Florian, Reuss, Alexander, Kommoss, Stefan, Marme, Frederik, Heimbach, Andre, Prieske, Katharina, Richters, Lisa Katharina, Burges, Alexander, Neidhardt, Guido, de Gregorio, Nikolaus, El-Balat, Ahmed, Hilpert, Felix, Meier, Werner, Heubner, Martin Leonhard, Kast, Karin, Braicu, Ioana, Hahnen, Eric, Schmutzler, Rita K.

“…Abstract only…”
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Prevalence of somatic mutations in risk genes including BRCA1/2 in consecutive ovarian cancer patients (AGO-TR-1 study) by Hahnen, Eric, Baumann, Klaus H., Heimbach, Andre, Reuss, Alexander, Jackisch, Christian, Hauke, Jan, Park-Simon, Tjoung-Won, Richters, Lisa Katharina, Hanker, Lars Christian, Kroeber, Sandra, Pfisterer, Jacobus, Gevensleben, Heidrun, Schnelzer, Andreas, Dietrich, Dimo, Schneider, Stephanie, Kommoss, Stefan, Marme, Frederic, Prieske, Katharina, Schmutzler, Rita K., Harter, Philipp

“…Abstract only…”
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