Search Results - "Heimbürger, Sebastian M"

Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease by Heimbürger, Sebastian M., Bergmann, Natasha C., Augustin, Robert, Gasbjerg, Lærke S., Christensen, Mikkel B., Knop, Filip K.

“…•GIP seems to regulate lipid uptake and lipolysis in cardiac and adipose tissue.•In the vasculature, GIP may increase vasodilation and leukocyte adhesion.•The…”
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No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes by Bergmann, Natasha C, Gasbjerg, Lærke S, Heimbürger, Sebastian M, Krogh, Liva S L, Dela, Flemming, Hartmann, Bolette, Holst, Jens J, Jessen, Lene, Christensen, Mikkel B, Vilsbøll, Tina, Lund, Asger, Knop, Filip K

“…Dual incretin receptor agonists in clinical development have shown reductions in body weight and hemoglobin A (HbA ) in patients with type 2 diabetes, but the…”
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The effect of 6-day subcutaneous glucose-dependent insulinotropic polypeptide infusion on time in glycaemic range in patients with type 1 diabetes: a randomised, double-blind, placebo-controlled crossover trial by Heimbürger, Sebastian M. N., Hoe, Bjørn, Nielsen, Chris N., Bergmann, Natasha C., Hartmann, Bolette, Holst, Jens J., Vilsbøll, Tina, Dejgaard, Thomas F., Christensen, Mikkel B., Knop, Filip K.

“…Aims/hypothesis Type 1 diabetes is characterised by reduced glucagon response to hypoglycaemia, increasing the risk of insulin treatment-associated…”
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The efficacy and safety of exenatide once weekly in patients with type 2 diabetes by Heimbürger, Sebastian M, Brønden, Andreas, Johansen, Nicklas J, Dejgaard, Thomas F, Vilsbøll, Tina, Knop, Filip K

“…Exenatide once weekly (QW) is a glucagon-like peptide 1 receptor agonist (GLP-1RA) that was approved in 2012 in Europe and the U.S.A. for the treatment of type…”
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Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment by Hagemann, Christoffer A, Zhang, Chen, Hansen, Henrik H, Jorsal, Tina, Rigbolt, Kristoffer T G, Madsen, Martin R, Bergmann, Natasha C, Heimbürger, Sebastian M N, Falkenhahn, Mechthilde, Theis, Stefan, Breitschopf, Kristin, Holm, Stephanie, Hedegaard, Morten A, Christensen, Mikkel B, Vilsbøll, Tina, Holst, Birgitte, Vrang, Niels, Jelsing, Jacob, Knop, Filip K

“…Abstract Context The mechanisms underlying Roux-en-Y gastric bypass (RYGB) surgery-induced weight loss and the immediate postoperative beneficial metabolic…”
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GIP’s involvement in the pathophysiology of type 2 diabetes by Christensen, Mikkel B., Gasbjerg, Lærke S., Heimbürger, Sebastian M., Stensen, Signe, Vilsbøll, Tina, Knop, Filip K.

“…•Impaired insulinotropic effect of GIP occurs secondary to the development of diabetes.•GIP may further impair the weakened postprandial glucagon suppression…”
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1215-P: Effects of Exogenous Secretin on Postprandial Plasma Glucose and Lipids and Gallbladder Motility and Hemodynamics in Man by BENTZEN, MARIA J., HEIMBÜRGER, SEBASTIAN M. NGUYEN, HARTMANN, BOLETTE, HOLST, JENS J., CHRISTENSEN, MIKKEL B., KNOP, FILIP K.

“…Secretin is best known for its effect on pancreatic exocrine secretion. It also has osmoregulatory effects and was recently identified as a potential target…”
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1224-P: Exogenous Secretin Decreases Energy Intake and Exerts a Bimodular Effect on Postprandial Brown Adipose Tissue Activation in Man by HEIMBÜRGER, SEBASTIAN M. NGUYEN, BENTZEN, MARIA J., HARTMANN, BOLETTE, HOLST, JENS J., CHRISTENSEN, MIKKEL B., KNOP, FILIP K.

“…Secretin was recently shown to constitute a postprandial satiety signal in mice. This effect was proposed to be mediated by secretin-induced activation of…”
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107-OR: Six-Day Subcutaneous GIP Infusion Increases Circulating Free Fatty Acids without Altering the Adipose Tissue Transcriptome, Adipocyte GIP Receptor Levels, or Circulating Inflammation Markers in Patients with Type 1 Diabetes by HEIMBÜRGER, SEBASTIAN M. NGUYEN, HOE, BJØRN, NIELSEN, CHRIS N., HARTMANN, BOLETTE, HOLST, JENS J., DELA, FLEMMING, OVERGAARD, ANNE JULIE, STØRLING, JOACHIM, VILSBØLL, TINA, DEJGAARD, THOMAS F., PYKE, CHARLES, CHRISTENSEN, MIKKEL B., KNOP, FILIP K.

“…Glucose-dependent insulinotropic polypeptide (GIP) has been proposed to increase adipose tissue lipolysis (at low insulin levels), adipokine secretion and…”
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89-LB: The Effect of GIP on Plasma Glucose in a Setting of Prandial Insulin Overdose and Physical Activity after Meal Intake in Patients with Type 1 Diabetes by HOE, BJØRN, NGUYEN HEIMBÜRGER, SEBASTIAN M., GASBJERG, LÆRKE S., LYNGGAARD, MADS B., HARTMANN, BOLETTE, HOLST, JENS J., VILSBØLL, TINA, LUND, ASGER, ENGBERG, SUSANNE, DEJGAARD, THOMAS F., CHRISTENSEN, MIKKEL B., KNOP, FILIP K.

“…Gluco-regulatory effects of the insulinotropic and glucagonotropic gut hormone glucose-dependent insulinotropic polypeptide (GIP) in type 1 diabetes (T1D) are…”
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351-OR: Six-Day Subcutaneous GIP Infusion Increases Glycemic Time-in-Range in Patients with Type 1 Diabetes by NGUYEN HEIMBÜRGER, SEBASTIAN M., HOE, BJØRN, NIELSEN, CHRIS N., BERGMANN, NATASHA C., HARTMANN, BOLETTE, HOLST, JENS J., STØRLING, JOACHIM, VILSBØLL, TINA, DEJGAARD, THOMAS F., CHRISTENSEN, MIKKEL B., KNOP, FILIP K.

“…The glucagonotropic effect of glucose-dependent insulinotropic polypeptide (GIP) during insulin-induced hypoglycemia in patients with type 1 diabetes (T1D)…”
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Glucose‐dependent insulinotropic polypeptide induces lipolysis during stable basal insulin substitution and hyperglycaemia in men with type 1 diabetes: A randomized, double‐blind, placebo‐controlled, crossover clinical trial by Heimburger, Sebastian M.N., Nielsen, Chris N., Calanna, Salvatore, Holst, Jens J., Vilsbøll, Tina, Knop, Filip K., Christensen, Mikkel B.

“…Glucose‐dependent insulinotropic polypeptide (GIP) plays an important role in the glucose and lipid metabolism. We investigated the effects of exogenous GIP on…”
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733 HEPATOPROTECTIVE EFFECTS OF SEMAGLUTIDE IN THE GAN DIET-INDUCED OBESE AND BIOPSY-CONFIRMED MOUSE MODEL OF NASH WITH ADVANCED FIBROSIS AND HEPATOCELLULAR CARCINOMA by Heimbürger, Sebastian M⊘ller Nguyen, Nielsen, Malte H., M⊘llerh⊘j, Mathias Bonde, Oró, Denise, Madsen, Martin R., Vyberg, Mogens, Hansen, Henrik H., Feigh, Michael

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648-P: Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Lipolysis during Stable Basal Insulin Substitution and Hyperglycemia in Men with Type 1 Diabetes by NIELSEN, CHRIS N., HEIMBÜRGER, SEBASTIAN M. NGUYEN, CALANNA, SALVATORE, HOLST, JENS J., VILSBØLL, TINA, KNOP, FILIP K., CHRISTENSEN, MIKKEL B.

“…Glucose-dependent insulinotropic polypeptide (GIP) contributes importantly to postprandial insulin secretion, and - perhaps primarily due to this…”
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Secretin infusion decreases food intake in healthy men – a randomized, placebo-controlled, double-blind, crossover study by Heimbürger, Sebastian M N, Bentzen, Maria J, Kizilkaya, Hüsün S, Hartmann, Bolette, Holst, Jens J, Rosenkilde, Mette M, Dela, Flemming, Hansen, Svend H, Rehfeld, Jens F, Christensen, Mikkel B, Knop, Filip K

“…The hormone secretin, best known for regulating pH in the duodenum, has anorectic properties in mice proposedly mediated via secretin-induced brown adipose…”
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Mono- and Co-Activation of the GIP and GLP-1 Receptors Inhibits Bone Resorption by BERGMANN, NATASHA C., LUND, ASGER B., HEIMBÜRGER, SEBASTIAN M., JESSEN, LENE, CHRISTENSEN, MIKKEL B., VILSBØLL, TINA, KNOP, FILIP K.

“…We investigated the effect of mono- and co-administration of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like…”
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