Search Results - "Heiman, Myriam"

Normal aging induces A1-like astrocyte reactivity by Clarke, Laura E., Liddelow, Shane A., Chakraborty, Chandrani, Münch, Alexandra E., Heiman, Myriam, Barres, Ben A.

“…The decline of cognitive function occurs with aging, but the mechanisms responsible are unknown. Astrocytes instruct the formation, maturation, and elimination…”
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Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP) by Heiman, Myriam, Kulicke, Ruth, Fenster, Robert J, Greengard, Paul, Heintz, Nathaniel

“…Translating ribosome affinity purification (TRAP) combines cell type–specific transgene expression with affinity purification of translating ribosomes and can…”
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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia by Fieblinger, Tim, Graves, Steven M., Sebel, Luke E., Alcacer, Cristina, Plotkin, Joshua L., Gertler, Tracy S., Chan, C. Savio, Heiman, Myriam, Greengard, Paul, Cenci, M. Angela, Surmeier, D. James

“…The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the…”
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Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development by Xu, Huixin, Fame, Ryann M., Sadegh, Cameron, Sutin, Jason, Naranjo, Christopher, Della Syau, Cui, Jin, Shipley, Frederick B., Vernon, Amanda, Gao, Fan, Zhang, Yong, Holtzman, Michael J., Heiman, Myriam, Warf, Benjamin C., Lin, Pei-Yi, Lehtinen, Maria K.

“…Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal…”
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Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy by Dvela-Levitt, Moran, Kost-Alimova, Maria, Emani, Maheswarareddy, Kohnert, Eva, Thompson, Rebecca, Sidhom, Eriene-Heidi, Rivadeneira, Ana, Sahakian, Nareh, Roignot, Julie, Papagregoriou, Gregory, Montesinos, Monica S., Clark, Abbe R., McKinney, David, Gutierrez, Juan, Roth, Mark, Ronco, Lucienne, Elonga, Esther, Carter, Todd A., Gnirke, Andreas, Melanson, Michelle, Hartland, Kate, Wieder, Nicolas, Hsu, Jane C.-H., Deltas, Constantinos, Hughey, Rebecca, Bleyer, Anthony J., Kmoch, Stanislav, Živná, Martina, Barešova, Veronika, Kota, Savithri, Schlondorff, Johannes, Heiman, Myriam, Alper, Seth L., Wagner, Florence, Weins, Astrid, Golub, Todd R., Lander, Eric S., Greka, Anna

“…Intracellular accumulation of misfolded proteins causes toxic proteinopathies, diseases without targeted therapies. Mucin 1 kidney disease (MKD) results from a…”
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Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease by Matsushima, Ayano, Pineda, Sergio Sebastian, Crittenden, Jill R., Lee, Hyeseung, Galani, Kyriakitsa, Mantero, Julio, Tombaugh, Geoffrey, Kellis, Manolis, Heiman, Myriam, Graybiel, Ann M.

“…Striatal projection neurons (SPNs), which progressively degenerate in human patients with Huntington’s disease (HD), are classified along two axes: the…”
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Widespread Accumulation of Ribosome-Associated Isolated 3′ UTRs in Neuronal Cell Populations of the Aging Brain by Sudmant, Peter H., Lee, Hyeseung, Dominguez, Daniel, Heiman, Myriam, Burge, Christopher B.

“…Particular brain regions and cell populations exhibit increased susceptibility to aging-related stresses. Here, we describe the age-specific and…”
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A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma membrane by Guillén-Samander, Andrés, Wu, Yumei, Pineda, S Sebastian, García, Francisco J, Eisen, Julia N, Leonzino, Marianna, Ugur, Berrak, Kellis, Manolis, Heiman, Myriam, De Camilli, Pietro

“…Chorea-acanthocytosis (ChAc) and McLeod syndrome are diseases with shared clinical manifestations caused by mutations in VPS13A and XK, respectively. Key…”
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A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types by Heiman, Myriam, Schaefer, Anne, Gong, Shiaoching, Peterson, Jayms D., Day, Michelle, Ramsey, Keri E., Suárez-Fariñas, Mayte, Schwarz, Cordelia, Stephan, Dietrich A., Surmeier, D. James, Greengard, Paul, Heintz, Nathaniel

“…The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using bacterial artificial…”
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Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types by Doyle, Joseph P., Dougherty, Joseph D., Heiman, Myriam, Schmidt, Eric F., Stevens, Tanya R., Ma, Guojun, Bupp, Sujata, Shrestha, Prerana, Shah, Rajiv D., Doughty, Martin L., Gong, Shiaoching, Greengard, Paul, Heintz, Nathaniel

“…Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity…”
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Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia by Heiman, Myriam, Heilbut, Adrian, Francardo, Veronica, Kulicke, Ruth, Fenster, Robert J., Kolaczyk, Eric D., Mesirov, Jill P., Surmeier, Dalton J., Cenci, M. Angela, Greengard, Paul

“…Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost all patients receiving levodopa eventually develop debilitating…”
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Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution by Fame, Ryann M., Kalugin, Peter N., Petrova, Boryana, Xu, Huixin, Soden, Paul A., Shipley, Frederick B., Dani, Neil, Grant, Bradford, Pragana, Aja, Head, Joshua P., Gupta, Suhasini, Shannon, Morgan L., Chifamba, Fortunate F., Hawks-Mayer, Hannah, Vernon, Amanda, Gao, Fan, Zhang, Yong, Holtzman, Michael J., Heiman, Myriam, Andermann, Mark L., Kanarek, Naama, Lipton, Jonathan O., Lehtinen, Maria K.

“…Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain states via regulation of cerebrospinal fluid (CSF)…”
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Interleukin-6 deficiency exacerbates Huntington's disease model phenotypes by Wertz, Mary H, Pineda, S Sebastian, Lee, Hyeseung, Kulicke, Ruth, Kellis, Manolis, Heiman, Myriam

“…Huntington's disease (HD) is an incurable neurodegenerative disorder caused by CAG trinucleotide expansions in the huntingtin gene. Markers of both systemic…”
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TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression by Garcia-Montojo, Marta, Fathi, Saeed, Rastegar, Cyrus, Simula, Elena Rita, Doucet-O’Hare, Tara, Cheng, Y. H. Hank, Abrams, Rachel P. M., Pasternack, Nicholas, Malik, Nasir, Bachani, Muzna, Disanza, Brianna, Maric, Dragan, Lee, Myoung-Hwa, Wang, Herui, Santamaria, Ulisses, Li, Wenxue, Sampson, Kevon, Lorenzo, Juan Ramiro, Sanchez, Ignacio E., Mezghrani, Alexandre, Li, Yan, Sechi, Leonardo Antonio, Pineda, Sebastian, Heiman, Myriam, Kellis, Manolis, Steiner, Joseph, Nath, Avindra

“…TAR DNA-binding protein 43 (TDP-43) proteinopathy in brain cells is the hallmark of amyotrophic lateral sclerosis (ALS) but its cause remains elusive…”
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Regulation of Alzheimer's disease amyloid-β formation by casein kinase I by Flajolet, Marc, He, Gen, Heiman, Myriam, Lin, Angie, Nairn, Angus C, Greengard, Paul

“…Alzheimer's disease (AD) is associated with accumulation of the neurotoxic peptide amyloid-β (Aβ), which is produced by sequential cleavage of amyloid…”
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Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease by Shema, Reut, Kulicke, Ruth, Cowley, Glenn S., Stein, Rachael, Root, David E., Heiman, Myriam

“…Huntington’s disease, the most common inherited neurodegenerative disease, is characterized by a dramatic loss of deep-layer cortical and striatal neurons, as…”
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Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements by Pirhaji, Leila, Milani, Pamela, Dalin, Simona, Wassie, Brook T., Dunn, Denise E., Fenster, Robert J., Avila-Pacheco, Julian, Greengard, Paul, Clish, Clary B., Heiman, Myriam, Lo, Donald C., Fraenkel, Ernest

“…The immense and growing repositories of transcriptional data may contain critical insights for developing new therapies. Current approaches to mining these…”
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l-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice by Santini, Emanuela, Alcacer, Cristina, Cacciatore, Silvia, Heiman, Myriam, Hervé, Denis, Greengard, Paul, Girault, Jean-Antoine, Valjent, Emmanuel, Fisone, Gilberto

“…In the dopamine-depleted striatum, extracellular signal-regulated kinase (ERK) signaling is implicated in the development of l-DOPA-induced dyskinesia. To gain…”
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Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin by Megret, Lucile, Gris, Barbara, Sasidharan Nair, Satish, Cevost, Jasmin, Wertz, Mary, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F, Wilkinson, Hilary, Heiman, Myriam, Neri, Christian

“…Loss of cellular homeostasis has been implicated in the etiology of several neurodegenerative diseases (NDs). However, the molecular mechanisms that underlie…”
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Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons by Jordi, Emmanuelle, Heiman, Myriam, Marion-Poll, Lucile, Guermonprez, Pierre, Cheng, Shuk Kei, Nairn, Angus C., Greengard, Paul, Girault, Jean-Antoine

“…Drugs of abuse, such as cocaine, induce changes in gene expression and epigenetic marks including alterations in histone posttranslational modifications in…”
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