Search Results - "Heilmann, Joerg"

A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of Crepis spp by Barda, Christina, Anastasiou, Konstantina, Tzara, Ariadni, Grafakou, Maria-Eleni, Kalpoutzakis, Eleftherios, Heilmann, Joerg, Rallis, Michael, Kourounakis, Angeliki P., Skaltsa, Helen

“…This study was designed to evaluate the chemical fingerprints and the antioxidant, anti-inflammatory and hypolipidemic activity of selected Crepis species…”
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In Vitro Metabolism of Six C-Glycosidic Flavonoids from Passiflora incarnata L by Tremmel, Martina, Kiermaier, Josef, Heilmann, Jörg

“…Several medical plants, such as Passiflora incarnata L., contain C-glycosylated flavonoids, which may contribute to their efficacy. Information regarding the…”
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Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode by Sawatzky, Edgar, Wehle, Sarah, Kling, Beata, Wendrich, Jan, Bringmann, Gerhard, Sotriffer, Christoph A, Heilmann, Jörg, Decker, Michael

“…Butyrylcholinesterase (BChE) is a promising target for the treatment of later stage cognitive decline in Alzheimer’s disease. A set of pseudo-irreversible BChE…”
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Phytochemical Characterization of Phitosia crocifolia, a Monotypic Representative of Greek Flora by Barda, Christina, Tzoumaka, Alexia, Grafakou, Maria-Eleni, Kalpoutzakis, Eleutherios, Heilmann, Joerg, Skaltsa, Helen

“…Within the large Compositae family, is considered a monotypic genus of the Greek flora, with its only species (Boiss. & Heldr.) Kamari & Greuter growing wild…”
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Macrocyclic Diterpenoid Constituents of Euphorbia deflexa, an Endemic Spurge from Greece by Grafakou, Maria-Eleni, Barda, Christina, Heilmann, Joerg, Skaltsa, Helen

“…Euphorbia deflexa, an endemic spurge from Greece, was investigated for the occurrence of its diterpene constituents. Through continuous monitoring by 1H NMR,…”
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Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect by Vogel, Susanne, Barbic, Matej, Jürgenliemk, Guido, Heilmann, Jörg

“…Besides 2′,4′-dihydroxy-4,6′-dimethoxy-3′-prenylchalcone ( 1) and 4-acetoxy-2′,4′-dihydroxy-6′-methoxy-3′-prenylchalkon ( 2), both phase II metabolites of…”
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In Vitro Liver Metabolism of Six Flavonoid C-Glycosides by Tremmel, Martina, Paetz, Christian, Heilmann, Jörg

“…Several medical plants belonging to the genera , , and accumulate flavonoid C-glycosides, which likely contribute to their efficacy. Information regarding…”
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Study on the metabolism of natural sesquiterpene lactones in human liver microsomes using LC-Q-TOF-MS/MS by Grafakou, Maria-Eleni, Barda, Christina, Skaltsa, Helen, Heilmann, Joerg

“…Sesquiterpene lactones are naturally occurring, highly active ­specialised metabolites, which are biosynthesized by important medicinal plants, fulfilling many…”
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An Unprecedented 4,8-Cycloeudesmane, Further New Sesquiterpenoids, a Triterpene, Steroids, and a Lignan from the Resin of Commiphora myrrha and Their Anti-Inflammatory Activity In Vitro by Unterholzner, Anna, Kuck, Katrin, Weinzierl, Anna, Lipowicz, Bartosz, Heilmann, Jörg

“…Myrrh has a long tradition in the treatment of inflammatory diseases. However, many of its (active) constituents are still unknown. In the present study,…”
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Phenolic metabolites from Hypericum kelleri Bald., an endemic species of Crete (Greece) by Mathioudaki, Angeliki, Berzesta, Ariola, Kypriotakis, Zacharias, Skaltsa, Helen, Heilmann, Jörg

“…Thirteen compounds were isolated from the aerial parts of Hypericum kelleri Bald., growing as an endemic on the island of Crete (Greece). These compounds…”
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Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility by Huang, Guozheng, Drakopoulos, Antonios, Saedtler, Marco, Zou, Huijuan, Meinel, Lorenz, Heilmann, Jörg, Decker, Michael

“…[Display omitted] The alkaloid rutaecarpine and its derivatives have been described as cytotoxic and hold potential as antitumor agents. Nevertheless, their…”
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A Bio-Guided Screening for Antioxidant, Anti-Inflammatory and Hypolipidemic Potential Supported by Non-Targeted Metabolomic Analysis of ICrepis/I spp by Barda, Christina, Anastasiou, Konstantina, Tzara, Ariadni, Grafakou, Maria-Eleni, Kalpoutzakis, Eleftherios, Heilmann, Joerg, Rallis, Michael, Kourounakis, Angeliki P, Skaltsa, Helen

“…This study was designed to evaluate the chemical fingerprints and the antioxidant, anti-inflammatory and hypolipidemic activity of selected Crepis species…”
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Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates by Fang, Lei, Kraus, Birgit, Lehmann, Jochen, Heilmann, Joerg, Zhang, Yihua, Decker, Michael

“…Novel ChE inhibitory (IC 50: AChE 4.4–38.6 nM; BChE 5.9–34.1 nM) and antioxidant (0.4–2.0 equiv to Trolox) tacrine–ferulic acid hybrids are reported. Five…”
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Investigation of the flavan-3-ol patterns in willow species during one growing-season by Wiesneth, Stefan, Aas, Gregor, Heilmann, Jörg, Jürgenliemk, Guido

“…Flavonoids, proanthocyanidins (PAs) and salicylic alcohol derivatives are the main groups of ingredients in Salix needed as defensive tools and signal…”
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Secondary metabolites from the leaves of Juglans regia L by Schwindl, Sebastian, Kraus, Birgit, Heilmann, Jörg

“…One new diarylheptanoid (1) and one previously unknown ascorbic acid derivative (2) along with 48 known compounds including three ascorbic acid derivatives…”
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An organophotocatalytic late-stage N–CH3 oxidation of trialkylamines to N-formamides with O2 in continuous flow by Mandigma, Mark John P, Žurauskas, Jonas, MacGregor, Callum I, Edwards, Lee J, Shahin, Ahmed, Ludwig d'Heureuse, Yip, Philip, Birch, David J S, Gruber, Thomas, Heilmann, Jörg, John, Matthew P, Barham, Joshua P

“…We report an organophotocatalytic, N–CH3-selective oxidation of trialkylamines in continuous flow. Based on the 9,10-dicyanoanthracene (DCA) core, a new…”
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Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity by Vogel, Susanne, Ohmayer, Susanne, Brunner, Gabi, Heilmann, Jörg

“…A general strategy for the synthesis of 3′-prenylated chalcones was established and a series of prenylated hydroxychalcones, including the hop ( Humulus…”
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In vitro cytotoxic and anti-inflammatory activities of sesquiterpene lactones from Centaurea papposa (Coss.) Greuter by Grafakou, Maria-Eleni, Barda, Christina, Heilmann, Joerg, Skaltsa, Helen

“…In the pursuit of highly active specialized metabolites from endemic plants, Centaurea papposa (Coss.) Greuter, an endemic plant in Algeria and Tunisia, was…”
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Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties by Decker, Michael, Kraus, Birgit, Heilmann, Jörg

“…A set of hybrid molecules were synthesized out of lipoic acid, α,ω-diamines of different lengths serving as spacers, and cholinesterase (ChE) inhibiting [2,1-…”
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Sesquiterpenes from Myrrh and Their ICAM-1 Inhibitory Activity In Vitro by Kuck, Katrin, Jürgenliemk, Guido, Lipowicz, Bartosz, Heilmann, Jörg

“…By using various chromatographic steps (silica flash, CPC, preparative HPLC), 16 sesquiterpenes could be isolated from an ethanolic extract of myrrh resin…”
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