Search Results - "Heiland, Mona"

Distinct dynamics of neuronal activity during concurrent motor planning and execution by Eriksson, David, Heiland, Mona, Schneider, Artur, Diester, Ilka

“…The smooth conduct of movements requires simultaneous motor planning and execution according to internal goals. So far it remains unknown how such movement…”
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Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy by Brennan, Gary P., Bauer, Sebastian, Engel, Tobias, Jimenez-Mateos, Eva M., Del Gallo, Federico, Hill, Thomas D.M., Connolly, Niamh M.C., Costard, Lara S., Neubert, Valentin, Salvetti, Beatrice, Sanz-Rodriguez, Amaya, Heiland, Mona, Mamad, Omar, Brindley, Elizabeth, Norwood, Braxton, Batool, Aasia, Raoof, Rana, El-Naggar, Hany, Reschke, Cristina R., Delanty, Norman, Prehn, Jochen H.M., Fabene, Paolo, Mooney, Catherine, Rosenow, Felix, Henshall, David C.

“…Epilepsy diagnosis is complex, requires a team of specialists and relies on in-depth patient and family history, MRI-imaging and EEG monitoring. There is…”
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Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice by Mamad, Omar, Heiland, Mona, Lindner, Andreas U, Hill, Thomas D M, Ronroy, Ronan M, Rentrup, Kilian, Sanz-Rodriguez, Amaya, Langa, Elena, Heller, Janosch P, Moreno, Oscar, Llop, Jordi, Bhattacharya, Anindya, Palmer, James A, Ceusters, Marc, Engel, Tobias, Henshall, David C

“…There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses…”
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Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy by Brindley, Elizabeth, Heiland, Mona, Mooney, Catherine, Diviney, Mairead, Mamad, Omar, Hill, Thomas D M, Yan, Yan, Venø, Morten T, Reschke, Cristina R, Batool, Aasia, Langa, Elena, Sanz-Rodriguez, Amaya, Heller, Janosch P, Morris, Gareth, Conboy, Karen, Kjems, Jørgen, Brennan, Gary P, Henshall, David C

“…The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as…”
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BICS01 Mediates Reversible Anti-seizure Effects in Brain Slice Models of Epilepsy by Morris, Gareth, Heiland, Mona, Lamottke, Kai, Guan, Haifeng, Hill, Thomas D M, Zhou, Yijun, Zhu, Qianjin, Schorge, Stephanie, Henshall, David C

“…Drug-resistant epilepsy remains a significant clinical and societal burden, with one third of people with epilepsy continuing to experience seizures despite…”
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MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control by Heiland, Mona, Connolly, Niamh M C, Mamad, Omar, Nguyen, Ngoc T, Kesavan, Jaideep C, Langa, Elena, Fanning, Kevin, Sanfeliu, Albert, Yan, Yan, Su, Junyi, Venø, Morten T, Costard, Lara S, Neubert, Valentin, Engel, Tobias, Hill, Thomas D M, Freiman, Thomas M, Mahesh, Arun, Tiwari, Vijay K, Rosenow, Felix, Bauer, Sebastian, Kjems, Jørgen, Morris, Gareth, Henshall, David C

“…There remains an urgent need for new therapies for treatment-resistant epilepsy. Sodium channel blockers are effective for seizure control in common forms of…”
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Impact of JQ1 treatment on seizures, hippocampal gene expression, and gliosis in a mouse model of temporal lobe epilepsy by Harnett, Aileen, Mathoux, Justine, Wilson, Marc‐Michel, Heiland, Mona, Mamad, Omar, Srinivas, Sujithra, Sanfeliu, Albert, Sanz‐Rodriguez, Amaya, How, Kelvin Lau E., Delanty, Norman, Cryan, Jane, Brett, Francesca M., Farrell, Michael A., O'Brien, Donncha F., Henshall, David C., Brennan, Gary P.

“…Epilepsy is a neurological disease characterised by recurrent seizures with complex aetiology. Temporal lobe epilepsy, the most common form in adults, can be…”
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RET overexpression leads to increased brain metastatic competency in luminal breast cancer by Jagust, Petra, Powell, Aoibhin M, Ola, Mihaela, Watson, Louise, de Pablos-Aragoneses, Ana, García-Gómez, Pedro, Fallon, Ramón, Bane, Fiona, Heiland, Mona, Morris, Gareth, Cavanagh, Brenton, McGrath, Jason, Ottaviani, Daniela, Hegarty, Aisling, Cocchiglia, Sinéad, Sweeney, Kieron J, MacNally, Stephen, Brett, Francesca M, Cryan, Jane, Beausang, Alan, Morris, Patrick, Valiente, Manuel, Hill, Arnold D K, Varešlija, Damir, Young, Leonie S

“…Breast cancer brain metastasis is a rising occurrence, necessitating a better understanding of the mechanisms involved for effective management. Breast cancer…”
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Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice by Alves, Mariana, Gil, Beatriz, Villegas-Salmerón, Javier, Salari, Valentina, Martins-Ferreira, Ricardo, Arribas Blázquez, Marina, Menéndez Méndez, Aida, Da Rosa Gerbatin, Rogerio, Smith, Jonathon, de Diego-Garcia, Laura, Conte, Giorgia, Sierra-Marquez, Juan, Merino Serrais, Paula, Mitra, Meghma, Fernandez Martin, Ana, Wang, Yitao, Kesavan, Jaideep, Melia, Ciara, Parras, Alberto, Beamer, Edward, Zimmer, Béla, Heiland, Mona, Cavanagh, Brenton, Parcianello Cipolat, Rafael, Morgan, James, Teng, Xinchen, Prehn, Jochen H.M., Fabene, Paolo F., Bertini, Giuseppe, Artalejo, Antonio R., Ballestar, Esteban, Nicke, Annette, Olivos-Oré, Luis A., Connolly, Niamh M.C., Henshall, David C., Engel, Tobias

“…•P2X7R signaling regulates both glial and neuronal genes during seizures.•P2X7R deficiency in microglia reduces seizure severity and leads to an…”
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