Search Results - "Heil, Gerhard"

Second-Line Oxaliplatin, Folinic Acid, and Fluorouracil Versus Folinic Acid and Fluorouracil Alone for Gemcitabine-Refractory Pancreatic Cancer: Outcomes From the CONKO-003 Trial by OETTLE, Helmut, RIESS, Hanno, BISCHOFF, Sven, SINN, Marianne, DÖRKEN, Bernd, PELZER, Uwe, STIELER, Jens M, HEIL, Gerhard, SCHWANER, Ingo, SERAPHIN, Jörg, GÖRNER, Martin, MÖLLE, Matthias, GRETEN, Tim F, LAKNER, Volker

“…To assess the efficacy of a second-line regimen of oxaliplatin and folinic acid-modulated fluorouracil in patients with advanced pancreatic cancer who have…”
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Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial by Rummel, Mathias J, Prof Dr, Niederle, Norbert, Prof, Maschmeyer, Georg, Prof, Banat, G Andre, MD, von Grünhagen, Ulrich, MD, Losem, Christoph, MD, Kofahl-Krause, Dorothea, MD, Heil, Gerhard, Prof, Welslau, Manfred, MD, Balser, Christina, MD, Kaiser, Ulrich, Prof, Weidmann, Eckhart, Prof, Dürk, Heinz, MD, PhD, Ballo, Harald, MD, Stauch, Martina, MD, Roller, Fritz, MD, Barth, Juergen, Pharm, Hoelzer, Dieter, Prof, Hinke, Axel, PhD, Brugger, Wolfram, Prof

“…Summary Background Rituximab plus chemotherapy, most often CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), is the first-line standard of…”
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Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia by THOL, Felicitas, DAMM, Frederik, LÜBBERT, Michael, KANZ, Lothar, FIEDLER, Walter, KIRCHNER, Hartmut, HEIL, Gerhard, KRAUTER, Jürgen, GANSER, Arnold, HEUSER, Michael, LÜDEKING, Andrea, WINSCHEL, Claudia, WAGNER, Katharina, MORGAN, Michael, HAIYANG YUN, GÖHRING, Gudrun, SCHLEGELBERGER, Brigitte, HOELZER, Dieter

“…To study the incidence and prognostic impact of mutations in DNA methyltransferase 3A (DNMT3A) in patients with acute myeloid leukemia. A total of 489 patients…”
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Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia by Schlenk, Richard F, Döhner, Konstanze, Döhner, Hartmut, Krauter, Jürgen, Fröhling, Stefan, Corbacioglu, Andrea, Bullinger, Lars, Habdank, Marianne, Späth, Daniela, Morgan, Michael, Benner, Axel, Schlegelberger, Brigitte, Heil, Gerhard, Ganser, Arnold

“…Almost half of patients with acute myeloid leukemia (AML) do not have detectable cytogenetic abnormalities. This study of more than 870 such patients…”
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Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia—results of the AMLSG 11-08 trial by Paschka, Peter, Schlenk, Richard F, Weber, Daniela, Benner, Axel, Bullinger, Lars, Heuser, Michael, Gaidzik, Verena I, Thol, Felicitas, Agrawal, Mridul, Teleanu, Veronica, Lübbert, Michael, Fiedler, Walter, Radsak, Markus, Krauter, Jürgen, Horst, Heinz-A., Greil, Richard, Mayer, Karin, Kündgen, Andrea, Martens, Uwe, Heil, Gerhard, Salih, Helmut R, Hertenstein, Bernd, Schwänen, Carsten, Wulf, Gerald, Lange, Elisabeth, Pfreundschuh, Michael, Ringhoffer, Mark, Girschikofsky, Michael, Heinicke, Thomas, Kraemer, Doris, Göhring, Gudrun, Ganser, Arnold, Döhner, Konstanze, Döhner, Hartmut

“…In this phase Ib/IIa study (ClinicalTrials.gov Identifier: NCT00850382) of the German-Austrian AML Study Group (AMLSG) the multikinase inhibitor dasatinib was…”
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Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor by Wagner, Katharina, Damm, Frederik, Göhring, Gudrun, Görlich, Kerstin, Heuser, Michael, Schäfer, Irina, Ottmann, Oliver, Lübbert, Michael, Heit, Wolfgang, Kanz, Lothar, Schlimok, Günter, Raghavachar, Aruna A, Fiedler, Walter, Kirchner, Hartmut H, Brugger, Wolfram, Zucknick, Manuela, Schlegelberger, Brigitte, Heil, Gerhard, Ganser, Arnold, Krauter, Jürgen

“…We assessed the prognostic impact of IDH1 R132 mutations and a known single nucleotide polymorphism (SNP) located in the same exon of the IDH1 gene in patients…”
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A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy by LÜBBERT, Michael, RÜTER, Björn H, GALM, Oliver, BRUGGER, Wolfram, HEIL, Gerhard, HACKANSON, Björn, DESCHLER, Barbara, DÖHNER, Konstanze, HAGEMEIJER, Anne, WIJERMANS, Pierre W, DÖHNER, Hartmut, CLAUS, Rainer, SCHMOOR, Claudia, SCHMID, Mathias, GERMING, Ulrich, KUENDGEN, Andrea, RETHWISCH, Volker, GANSER, Arnold, PLATZBECKER, Uwe

“…The treatment of acute myeloid leukemia of older, medically non-fit patients still poses a highly unmet clinical need, and only few large, prospective studies…”
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Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia by Thol, Felicitas, Damm, Frederik, Wagner, Katharina, Göhring, Gudrun, Schlegelberger, Brigitte, Hoelzer, Dieter, Lübbert, Michael, Heit, Wolfgang, Kanz, Lothar, Schlimok, Günter, Raghavachar, Aruna, Fiedler, Walter, Kirchner, Hartmut, Heil, Gerhard, Heuser, Michael, Krauter, Jürgen, Ganser, Arnold

“…Mutations in the nicotinamide adenine dinucleotide phosphate+–dependent isocitrate dehydrogenase gene 2 (IDH2) have recently been found in patients with acute…”
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Acute Myeloid Leukemia (AML): Different Treatment Strategies Versus a Common Standard Arm—Combined Prospective Analysis by the German AML Intergroup by BÜCHNER, Thomas, SCHLENK, Richard F, SPÄTH, Daniela, KRAMER, Michael, SCHOLL, Sebastian, BERDEL, Wolfgang E, HIDDEMANN, Wolfgang, HOELZER, Dieter, HEHLMANN, Rüdiger, HASFORD, Joerg, HOFFMANN, Verena S, DÖHNER, Hartmut, SCHAICH, Markus, EHNINGER, Gerhard, GANSER, Arnold, NIEDERWIESER, Dietger W, PFIRRMANN, Markus, DÖHNER, Konstanze, KRAHL, Rainer, KRAUTER, Jürgen, HEIL, Gerhard, KRUG, Utz, SAUERLAND, Maria Cristina, HEINECKE, Achim

“…Identifying true therapeutic progress in patients with acute myeloid leukemia (AML) requires a comparison of treatment strategies and results on the basis of…”
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Activity of decitabine combined with all- trans retinoic acid in oligoblastic acute myeloid leukemia: results from a randomized 2x2 phase II trial (DECIDER) by Rummelt, Christoph, Grishina, Olga, Schmoor, Claudia, Crysandt, Martina, Heuser, Michael, Götze, Katharina S, Schlenk, Richard F, Döhner, Konstanze, Salih, Helmut R, Heil, Gerhard, Müller-Tidow, Carsten, Brugger, Wolfram, Kündgen, Andrea, De Wit, Maike, Giagounidis, Aristoteles, Scholl, Sebastian, Neubauer, Andreas, Krauter, Jürgen, Bug, Gesine, Al-Ali, Haifa Kathrin, Wäsch, Ralph, Becker, Heiko, May, Annette M, Duyster, Justus, Hackanson, Björn, Ganser, Arnold, Döhner, Hartmut, Lübbert, Michael

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Single Nucleotide Polymorphism in the Mutational Hotspot of WT1 Predicts a Favorable Outcome in Patients With Cytogenetically Normal Acute Myeloid Leukemia by DAMM, Frederik, HEUSER, Michael, HEIT, Wolfgang, KANZ, Lothar, SCHLIMOK, Günter, RAGHAVACHAR, Aruna, FIEDLER, Walter, KIRCHNER, Hartmut, DÖHNER, Hartmut, HEIL, Gerhard, GANSER, Arnold, KRAUTER, Jürgen, MORGAN, Michael, HAIYANG YUN, GROSSHENNIG, Anika, GOHRING, Gudrun, SCHLEGELBERGER, Brigitte, DÖHNER, Konstanze, OTTMANN, Oliver, LÜBBERT, Michael

“…We assessed the prognostic impact of a known single nucleotide polymorphism (SNP) located in the mutational hotspot of WT1 in patients with cytogenetically…”
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Prognostic Factors in Adult Patients up to 60 Years Old With Acute Myeloid Leukemia and Translocations of Chromosome Band 11q23: Individual Patient Data–Based Meta-Analysis of the German Acute Myeloid Leukemia Intergroup by KRAUTER, Jürgen, WAGNER, Katharina, BÜCHNER, Thomas, SAUERLAND, Cristina, SCHLEGELBERGER, Brigitte, DÖHNER, Konstanze, DÖHNER, Hartmut, SCHLENK, Richard F, GANSER, Arnold, SCHÄFER, Irina, MARSCHALEK, Rolf, MEYER, Claus, HEIL, Gerhard, SCHAICH, Markus, EHNINGER, Gerhard, NIEDERWIESER, Dietger, KRAHL, Rainer

“…To identify risk factors for induction success and overall survival (OS) and relapse-free survival (RFS) and to evaluate the impact of allogeneic stem-cell…”
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Prognostic Importance of Histone Methyltransferase MLL5 Expression in Acute Myeloid Leukemia by Damm, Frederik, Oberacker, Tina, Thol, Felicitas, Surdziel, Ewa, Wagner, Katharina, Chaturvedi, Anuhar, Morgan, Michael, Bomm, Karoline, Göhring, Gudrun, Lübbert, Michael, Kanz, Lothar, Fiedler, Walter, Schlegelberger, Brigitte, Heil, Gerhard, Schlenk, Richard F, Döhner, Konstanze, Döhner, Hartmut, Krauter, Jürgen, Ganser, Arnold, Heuser, Michael

“…To assess the prognostic importance of mixed lineage leukemia 5 (MLL5) expression in acute myeloid leukemia (AML). MLL5 transcript levels from 509 patients…”
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FLT3-internal tandem duplication and age are the major prognostic factors in patients with relapsed acute myeloid leukemia with normal karyotype by Wagner, Katharina, Damm, Frederik, Thol, Felicitas, Göhring, Gudrun, Görlich, Kerstin, Heuser, Michael, Schäfer, Irina, Schlegelberger, Brigitte, Heil, Gerhard, Ganser, Arnold, Krauter, Jürgen

“…Several genetic aberrations with prognostic impact in first-line therapy have been described in patients with acute myeloid leukemia and normal karyotype…”
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Prognostic Value of Minimal Residual Disease Quantification by Real-Time Reverse Transcriptase Polymerase Chain Reaction in Patients With Core Binding Factor Leukemias by KRAUTER, Jürgen, GÖRLICH, Kerstin, OTTMANN, Oliver, LÜBBERT, Michael, DOHNER, Hartmut, HEIT, Wolfgang, KANZ, Lothar, GANSER, Arnold, HEIL, Gerhard

“…In patients with acute myeloblastic leukemia with t(8;21) or inv(16) aberrations (core binding factor [CBF] leukemias), minimal residual disease (MRD) can be…”
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Analysis of Concerted Expression of Angiogenic Growth Factors in Acute Myeloid Leukemia: Expression of Angiopoietin-2 Represents an Independent Prognostic Factor for Overall Survival by LOGES, Sonja, HEIL, Gerhard, BRUWELEIT, Melanie, SCHODER, Volker, BUTZAL, Martin, FISCHER, Uta, GEHLING, Ursula M, SCHUCH, Gunter, HOSSFELD, Dieter K, FIEDLER, Walter

“…Bone marrow neoangiogenesis plays an important pathogenetic and possible prognostic role in acute myeloid leukemia (AML). Members of the vascular endothelial…”
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Prognosis of acute myeloid leukemia patients up to 60 years of age exhibiting trisomy 8 within a non-complex karyotype: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup by Schaich, Markus, Schlenk, Richard F, Al-Ali, Haifa K, Dohner, Hartmut, Ganser, Arnold, Heil, Gerhard, Illmer, Thomas, Krahl, Rainer, Krauter, Jurgen, Sauerland, Cristina, Buchner, Thomas, Ehninger, Gerhard

“…From Department of Internal Medicine I, University of Dresden, Germany (MS, TI, GE); Department of Internal Medicine III, University of Ulm, Germany (RF.S,…”
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The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells by Martinez, Natalia, Drescher, Bettina, Riehle, Heidemarie, Cullmann, Claire, Vornlocher, Hans-Peter, Ganser, Arnold, Heil, Gerhard, Nordheim, Alfred, Krauter, Jürgen, Heidenreich, Olaf

“…The fusion protein RUNX1-CBFA2T1 associated with t(8;21)-positive acute myeloid leukaemia is a potent inhibitor of haematopoetic differentiation. The role of…”
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Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy by Tiesmeier, Jens, Müller-Tidow, Carsten, Westermann, Annette, Czwalinna, Andreas, Hoffmann, Mandy, Krauter, Jürgen, Heil, Gerhard, Ganser, Arnold, Serve, Hubert, Verbeek, Walter

“…Internal tandem duplications (ITDs) of the juxtamembrane region of the FLT3 tyrosine kinase receptor are the most frequent genetic alterations in acute myeloid…”
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Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG) by Gaidzik, Verena I., Schlenk, Richard F., Paschka, Peter, Stölzle, Anja, Späth, Daniela, Kuendgen, Andrea, von Lilienfeld-Toal, Marie, Brugger, Wolfram, Derigs, Hans Günter, Kremers, Stephan, Greil, Richard, Raghavachar, Aruna, Ringhoffer, Mark, Salih, Helmut R., Wattad, Mohammed, Kirchen, Heinz G., Runde, Volker, Heil, Gerhard, Petzer, Andreas L., Girschikofsky, Michael, Heuser, Michael, Kayser, Sabine, Goehring, Gudrun, Teleanu, Maria-Veronica, Schlegelberger, Brigitte, Ganser, Arnold, Krauter, Jürgen, Bullinger, Lars, Döhner, Hartmut, Döhner, Konstanze

“…In this study, we evaluated the frequency and prognostic impact of DNMT3A mutations (DNMT3Amut) in 1770 younger adult patients with acute myeloid leukemia…”
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