Search Results - "Heikkilä, Minna"

A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin by Tolonen, Jussi-Pekka, Heikkilä, Minna, Malinen, Marjo, Lee, Hang-Mao, Palvimo, Jorma J., Wei, Gong-Hong, Myllyharju, Johanna

“…Hypoxia-inducible factor (HIF), an αβ dimer, is the master regulator of oxygen homeostasis with hundreds of hypoxia-inducible target genes. Three HIF isoforms…”
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Wnt-4 Deficiency Alters Mouse Adrenal Cortex Function, Reducing Aldosterone Production by Heikkilä, Minna, Peltoketo, Hellevi, Leppäluoto, Juhani, Ilves, Mika, Vuolteenaho, Olli, Vainio, Seppo

“…Wnt-4 is a signaling factor with multiple roles in organogenesis, a deficiency that leads to abnormal development of the kidney, pituitary gland, female…”
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Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis by Laitala, Anu, Aro, Ellinoora, Walkinshaw, Gail, Mäki, Joni M., Rossi, Maarit, Heikkilä, Minna, Savolainen, Eeva-Riitta, Arend, Michael, Kivirikko, Kari I., Koivunen, Peppi, Myllyharju, Johanna

“…An endoplasmic reticulum transmembrane prolyl 4-hydroxylase (P4H-TM) is able to hydroxylate the α subunit of the hypoxia-inducible factor (HIF) in vitro and in…”
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The Partial Female to Male Sex Reversal in Wnt-4-Deficient Females Involves Induced Expression of Testosterone Biosynthetic Genes and Testosterone Production, and Depends on Androgen Action by Heikkilä, Minna, Prunskaite, Renata, Naillat, Florence, Itäranta, Petri, Vuoristo, Jussi, Leppäluoto, Juhani, Peltoketo, Hellevi, Vainio, Seppo

“…Wnt-4 signaling has been implicated in female development, because its absence leads to partial female to male sex reversal in the mouse. Instead of Mullerian…”
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Early gender differences in emotional expressions and self-regulation in settings of early childhood education and care by Veijalainen, Jouni, Reunamo, Jyrki, Heikkilä, Minna

“…This paper aims to determine possible gender differences in children's observed emotional expressions and their relationship with teacher-rated self-regulation…”
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Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response by Heikkilä, Minna, Pasanen, Annika, Kivirikko, Kari I., Myllyharju, Johanna

“…The hypoxia-inducible transcription factor (HIF) controls (in an oxygen-dependent manner) the expression of a large number of genes whose products are involved…”
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RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration by Gawecka, Joanna E., Young-Robbins, Shirley S., Sulzmaier, Florian J., Caliva, Maisel J., Heikkilä, Minna M., Matter, Michelle L., Ramos, Joe W.

“…Modulation of integrin activation is important in many cellular functions including adhesion, migration, and assembly of the extracellular matrix. RSK2…”
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Systemic long‐term inactivation of hypoxia‐inducible factor prolyl 4‐hydroxylase 2 ameliorates aging‐induced changes in mice without affecting their life span by Laitakari, Anna, Huttunen, Riikka, Kuvaja, Paula, Hannuksela, Pauliina, Szabo, Zoltan, Heikkilä, Minna, Kerkelä, Risto, Myllyharju, Johanna, Dimova, Elitsa Y., Serpi, Raisa, Koivunen, Peppi

“…Hypoxia inactivates hypoxia‐inducible factor (HIF) prolyl 4‐hydroxylases (HIF‐P4Hs), which stabilize HIF and upregulate genes to restore tissue oxygenation…”
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HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury by Karsikas, Sara, Myllymäki, Mikko, Heikkilä, Minna, Sormunen, Raija, Kivirikko, Kari I., Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi

“…We show here that mice hypomorphic for hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2) ( Hif-p4h-2 gt/gt ), the main regulator of the stability of…”
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Female development in mammals is regulated by Wnt-4 signalling by McMahon, Andrew P, Vainio, Seppo, Heikkilä, Minna, Kispert, Andreas, Chin, Norman

“…In the mammalian embryo, both sexes are initially morphologically indistinguishable: specific hormones are required for sex-specific development. Mullerian…”
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Hypoxia-inducible factor (HIF)-3α is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2 by Pasanen, Annika, Heikkilä, Minna, Rautavuoma, Kati, Hirsilä, Maija, Kivirikko, Kari I., Myllyharju, Johanna

“…The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells to hypoxia. HIFs are αβ dimers, the human α subunit having…”
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Effectiveness of the public health policy for breast cancer screening in Finland: population based cohort study by Hakama, Matti, Pukkala, Eero, HeikkilÄ, Minna, Kallio, Mervi

“…Abstract Objective: To evaluate the effectiveness of screening for breast cancer as a public health policy. Design: Follow up in 1987-92 of Finnish women…”
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Roles of the human hypoxia-inducible factor (HIF)-3[alpha] variants in the hypoxia response by Heikkilä, Minna, Pasanen, Annika, Kivirikko, Kari I, Myllyharju, Johanna

“…The hypoxia-inducible transcription factor (HIF) controls (in an oxygen-dependent manner) the expression of a large number of genes whose products are involved…”
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Is a dense mammographic parenchymal pattern a contraindication to hormonal replacement therapy? by Salminen, T M, Saarenmaa, I E, Heikkilä, M M, Hakama, M

“…The aim of the study was to find out whether the effect of hormonal replacement therapy (HRT) is modified by the mammographic parenchymal patterns on the risk…”
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Risk of breast cancer and changes in mammographic parenchymal patterns over time by Salminen, T M, Saarenmaa, I E, Heikkilä, M M, Hakama, M

“…The relationship between sequential mammographic parenchymal patterns and breast cancer was estimated and the results were applied to selective screening. In a…”
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Wnts and the female reproductive system by Heikkilä, Minna, Peltoketo, Hellevi, Vainio, Seppo

“…Wnts are intercellular growth and differentiation factors that regulate several key developmental steps, such as gastrulation, neurulation, and organogenesis,…”
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Molecular Genetic Studies of Wnt Signaling in the Mouse by Uusitalo, Marika, Heikkilä, Minna, Vainio, Seppo

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Hypoxia-inducible factor (HIF)-3a is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2 by Pasanen, Annika, Heikkilae, Minna, Rautavuoma, Kati, Hirsilae, Maija, Kivirikko, Kari I, Myllyharju, Johanna

“…The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells to hypoxia. HIFs are ab dimers, the human a subunit having…”
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Unfavourable change in mammographic patterns and the breast cancer risk factors by SALMINEN, T. M, SAARENMAA, I. E, HEIKKILÄ, M. M, HAKAMA, M

“…The purpose of the study was to estimate the incidence of unfavourable mammographic pattern by risk factors of breast cancers. Data consisted of 1890 Finnish…”
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Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2 by Pasanen, Annika, Heikkilä, Minna, Rautavuoma, Kati, Hirsilä, Maija, Kivirikko, Kari I, Myllyharju, Johanna

“…The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells to hypoxia. HIFs are alphabeta dimers, the human alpha subunit…”
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