Search Results - "Heikki Räikkönen"

Effect of colloidal silicon dioxide and moisture on powder flow properties: Predicting in-process performance using image-based analysis by Blanco, David, Antikainen, Osmo, Räikkönen, Heikki, Yliruusi, Jouko, Juppo, Anne Mari

“…[Display omitted] The effect of colloidal silicon dioxide (CSD) on powder flow properties of poor-flowing excipient lactose 200 M was investigated. Binary…”
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Wood hemicelluloses as sustainable wall materials to protect bioactive compounds during spray drying of bilberries by Halahlah, Abedalghani, Räikkönen, Heikki, Piironen, Vieno, Valoppi, Fabio, Mikkonen, Kirsi S., Ho, Thao M.

“…The most widely-used wall materials for spray-dried microencapsulation have limitations in cost-effectiveness, health benefits and sustainability. Wood…”
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Mass Spectrometry Imaging of Arabidopsis thaliana Leaves at the Single-Cell Level by Infrared Laser Ablation Atmospheric Pressure Photoionization (LAAPPI) by Hieta, Juha-Pekka, Sipari, Nina, Räikkönen, Heikki, Keinänen, Markku, Kostiainen, Risto

“…In this study, we show that infrared laser ablation atmospheric pressure photoionization mass spectrometry (LAAPPI-MS) imaging with 70 μm lateral resolution…”
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Sub-100 μm Spatial Resolution Ambient Mass Spectrometry Imaging of Rodent Brain with Laser Ablation Atmospheric Pressure Photoionization (LAAPPI) and Laser Ablation Electrospray Ionization (LAESI) by Hieta, Juha-Pekka, Kopra, Jaakko, Räikkönen, Heikki, Kauppila, Tiina J, Kostiainen, Risto

“…In this study, we applied a new IR laser-beam-focusing technique to enable sub-100 μm spatial resolution in laser ablation atmospheric pressure photoionization…”
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Image-based characterization of powder flow to predict the success of pharmaceutical minitablet manufacturing by Blanco, David, Antikainen, Osmo, Räikkönen, Heikki, Mah, Pei Ting, Healy, Anne Marie, Juppo, Anne Mari, Yliruusi, Jouko

“…[Display omitted] Powder flowability plays an important role in die filling during tablet manufacturing. The present study introduces a novel small-scale…”
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Predicting tablet tensile strength with a model derived from the gravitation-based high-velocity compaction analysis data by Tanner, Timo, Antikainen, Osmo, Pollet, Arne, Räikkönen, Heikki, Ehlers, Henrik, Juppo, Anne, Yliruusi, Jouko

“…[Display omitted] In the present study, a model was developed to estimate tablet tensile strength utilizing the gravitation-based high-velocity (G-HVC) method…”
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Wood hemicelluloses as effective wall materials for spray-dried microcapsulation of polyunsaturated fatty acid-rich oils by Ho, Thao M., Lehtonen, Mari, Räikkönen, Heikki, Kilpeläinen, Petri O., Mikkonen, Kirsi S.

“…[Display omitted] •Wood hemicelluloses (GGM and GX) were good wall materials to microencapsulate oil.•GGM and GX had much higher oil encapsulation efficiency…”
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Analysis of steroids in urine by gas chromatography-capillary photoionization-tandem mass spectrometry by Pöhö, Päivi, Scholz, Karen, Kärkkäinen, Niina, Haapala, Markus, Räikkönen, Heikki, Kostiainen, Risto, Vaikkinen, Anu

“…•New capillary photoionization (CPI) ion source design for coupling of GC to MS.•CPI produces intensive molecular ions of trimethylsilylated…”
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Comparison of melibiose and trehalose as stabilising excipients for spray-dried β-galactosidase formulations by Lipiäinen, Tiina, Räikkönen, Heikki, Kolu, Anna-Maija, Peltoniemi, Marikki, Juppo, Anne

“…[Display omitted] Spray-dried protein formulations commonly require stabilising excipients to prevent protein degradation during processing and storage, and…”
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Pectin and Mucin Enhance the Bioadhesion of Drug Loaded Nanofibrillated Cellulose Films by Laurén, Patrick, Paukkonen, Heli, Lipiäinen, Tiina, Dong, Yujiao, Oksanen, Timo, Räikkönen, Heikki, Ehlers, Henrik, Laaksonen, Päivi, Yliperttula, Marjo, Laaksonen, Timo

“…Purpose Bioadhesion is an important property of biological membranes, that can be utilized in pharmaceutical and biomedical applications. In this study, we…”
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Controlled Expansion of Supercritical Solution: A Robust Method to Produce Pure Drug Nanoparticles With Narrow Size-Distribution by Pessi, Jenni, Lassila, Ilkka, Meriläinen, Antti, Räikkönen, Heikki, Hæggström, Edward, Yliruusi, Jouko

“…We introduce a robust, stable, and reproducible method to produce nanoparticles based on expansion of supercritical solutions using carbon dioxide as a…”
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Development of a Formulation and In Vitro Evaluation of a Pulmonary Drug Delivery System for a Novel Janus Kinase (JAK) Inhibitor, CPL409116 by Rzewińska, Aleksandra, Szlęk, Jakub, Dąbrowski, Damian, Juszczyk, Ewelina, Mróz, Katarzyna, Räikkönen, Heikki, Siven, Mia, Wieczorek, Maciej, Dorożyński, Przemysław

“…The pursuit of targeted therapies for cytokine-dependent diseases has led to the discovery of Janus kinase (JAK) inhibitors, a promising class of drugs. Among…”
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Spray-dried amorphous isomalt and melibiose, two potential protein-stabilizing excipients by Lipiäinen, Tiina, Peltoniemi, Marikki, Räikkönen, Heikki, Juppo, Anne

“…[Display omitted] The possibility of producing amorphous isomalt and melibiose by spray drying was studied. The impact of process parameters on yield and…”
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Combination of carboxymethylcellulose and wood hemicelluloses to enhance encapsulation efficiency and microcapsule wall thickness by Halahlah, Abedalghani, Abik, Felix, Suhonen, Heikki, Räikkönen, Heikki, Piironen, Vieno, Mikkonen, Kirsi S., Ho, Thao M.

“…•Carboxymethylcellulose (CMC) was used as a co-encapsulant for wood hemicelluloses.•CMC at 0.5 % (w/w) improved the encapsulation efficiency of hemicelluloses…”
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A Simple Method for Improving the Spatial Resolution in Infrared Laser Ablation Mass Spectrometry Imaging by Hieta, Juha-Pekka, Vaikkinen, Anu, Auno, Samuli, Räikkönen, Heikki, Haapala, Markus, Scotti, Gianmario, Kopra, Jaakko, Piepponen, Petteri, Kauppila, Tiina J.

“…In mass spectrometry imaging of tissues, the size of structures that can be distinguished is determined by the spatial resolution of the imaging technique…”
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Granule size distribution of tablets by Virtanen, Satu, Antikainen, Osmo, Räikkönen, Heikki, Yliruusi, Jouko

“…The purpose of this study was to determine the variation in the granule size distribution in a die of an eccentric tableting machine. Theophylline anhydrate…”
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Controlling granule size by granulation liquid feed pulsing by Närvänen, Tero, Lipsanen, Tanja, Antikainen, Osmo, Räikkönen, Heikki, Yliruusi, Jouko

“…The effects of inlet air humidity, granulation liquid feed rate and granulation liquid feed pulsing on the particle-size distribution of final granules were…”
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Rapid Particle Size Measurement Using 3D Surface Imaging by Soppela, Ira, Airaksinen, Sari, Hatara, Juha, Räikkönen, Heikki, Antikainen, Osmo, Yliruusi, Jouko, Sandler, Niklas

“…The present study introduces a new three-dimensional (3D) surface image analysis technique in which white light illumination from different incident angles is…”
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Gaining fluid bed process understanding by in-line particle size analysis by Närvänen, Tero, Lipsanen, Tanja, Antikainen, Osmo, Räikkönen, Heikki, Heinämäki, Jyrki, Yliruusi, Jouko

“…Different process phenomena and process failure modes could be monitored using the in-line particle size data measured by spatial filtering technique (SFT). In…”
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Improving flow properties of ibuprofen by fluidized bed particle thin-coating by Ehlers, Henrik, Räikkönen, Heikki, Antikainen, Osmo, Heinämäki, Jyrki, Yliruusi, Jouko

“…The surfaces of ibuprofen particles (d50 42μm) were modified by coating the particles with diluted aqueous hydroxypropyl methylcellulose (HPMC) solution in an…”
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