Search Results - "Heijnen, Nanon F. L."

Associations of early changes in lung ultrasound aeration scores and mortality in invasively ventilated patients: a post hoc analysis by Sinnige, Jante S, Filippini, Daan F L, Hagens, Laura A, Heijnen, Nanon F L, Schnabel, Ronny M, Schultz, Marcus J, Bergmans, Dennis C J J, Bos, Lieuwe D J, Smit, Marry R

“…Lung ultrasound (LUS) in an emerging technique used in the intensive care unit (ICU). The derivative LUS aeration score has been shown to have associations…”
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Towards a biological definition of ARDS: are treatable traits the solution? by Bos, Lieuwe D. J., Laffey, John G., Ware, Lorraine B., Heijnen, Nanon F. L., Sinha, Pratik, Patel, Brijesh, Jabaudon, Matthieu, Bastarache, Julie A., McAuley, Daniel F., Summers, Charlotte, Calfee, Carolyn S., Shankar-Hari, Manu

“…The pathophysiology of acute respiratory distress syndrome (ARDS) includes the accumulation of protein-rich pulmonary edema in the air spaces and interstitial…”
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HS-GC–MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study by Lilien, Thijs A., Fenn, Dominic W., Brinkman, Paul, Hagens, Laura A., Smit, Marry R., Heijnen, Nanon F. L., van Woensel, Job B. M., Bos, Lieuwe D. J., Bem, Reinout A.

“…Background Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia…”
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Breath metabolomics for diagnosis of acute respiratory distress syndrome by Zhang, Shiqi, Hagens, Laura A, Heijnen, Nanon F L, Smit, Marry R, Brinkman, Paul, Fenn, Dominic, van der Poll, Tom, Schultz, Marcus J, Bergmans, Dennis C J J, Schnabel, Ronny M, Bos, Lieuwe D J

“…Acute respiratory distress syndrome (ARDS) poses challenges in early identification. Exhaled breath contains metabolites reflective of pulmonary inflammation…”
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Assessment of the Effect of Recruitment Maneuver on Lung Aeration Through Imaging Analysis in Invasively Ventilated Patients: A Systematic Review by Pierrakos, Charalampos, Smit, Marry R., Hagens, Laura A., Heijnen, Nanon F. L., Hollmann, Markus W., Schultz, Marcus J., Paulus, Frederique, Bos, Lieuwe D. J.

“…Background: Recruitment maneuvers (RMs) have heterogeneous effects on lung aeration and have adverse side effects. We aimed to identify morphological,…”
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Biological subphenotypes of acute respiratory distress syndrome may not reflect differences in alveolar inflammation by Heijnen, Nanon F. L., Hagens, Laura A., Smit, Marry R., Schultz, Marcus J., Poll, Tom, Schnabel, Ronny M., Horst, Iwan C. C., Dickson, Robert P., Bergmans, Dennis C. J. J., Bos, Lieuwe D. J.

“…Biological subphenotypes have been identified in acute respiratory distress syndrome (ARDS) based on two parsimonious models: the “uninflamed” and “reactive”…”
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Prognostic Value of the Radiographic Assessment of Lung Edema Score in Mechanically Ventilated ICU Patients by Filippini, Daan F L, Hagens, Laura A, Heijnen, Nanon F L, Zimatore, Claudio, Atmowihardjo, Leila N, Schnabel, Ronny M, Schultz, Marcus J, Bergmans, Dennis C J J, Bos, Lieuwe D J, Smit, Marry R

“…The Radiographic Assessment of Lung Edema (RALE) score provides a semi-quantitative measure of pulmonary edema. In patients with acute respiratory distress…”
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Improvement of an interobserver agreement of ARDS diagnosis by adding additional imaging and a confidence scale by Hagens, Laura A., Van der Ven, Fleur L. I. M., Heijnen, Nanon F. L., Smit, Marry R., Gietema, Hester A., Gerretsen, Suzanne C., Schultz, Marcus J., Bergmans, Dennis C. J. J., Schnabel, Ronny M., Bos, Lieuwe D. J.

“…Acute respiratory distress syndrome (ARDS) often is not recognized in clinical practice, largely due to variation in the interpretation of chest x-ray (CXR)…”
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Lung Ultrasound Prediction Model for Acute Respiratory Distress Syndrome: A Multicenter Prospective Observational Study by Smit, Marry R, Hagens, Laura A, Heijnen, Nanon F L, Pisani, Luigi, Cherpanath, Thomas G V, Dongelmans, Dave A, de Grooth, Harm-Jan S, Pierrakos, Charalampos, Tuinman, Pieter Roel, Zimatore, Claudio, Paulus, Frederique, Schnabel, Ronny M, Schultz, Marcus J, Bergmans, Dennis C J J, Bos, Lieuwe D J

“…Lung ultrasound (LUS) is a promising tool for diagnosis of acute respiratory distress syndrome (ARDS), but adequately sized studies with external validation…”
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Lung Ultrasound Signs to Diagnose and Discriminate Interstitial Syndromes in ICU Patients: A Diagnostic Accuracy Study in Two Cohorts by Heldeweg, Micah L. A., Smit, Marry R., Kramer-Elliott, Shelley R., Haaksma, Mark E., Smit, Jasper M., Hagens, Laura A., Heijnen, Nanon F. L., Jonkman, Annemijn H., Paulus, Frederique, Schultz, Marcus J., Girbes, Armand R. J., Heunks, Leo M. A., Bos, Lieuwe D. J., Tuinman, Pieter R.

“…To determine the diagnostic accuracy of lung ultrasound signs for both the diagnosis of interstitial syndrome and for the discrimination of noncardiogenic…”
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Biological Subphenotypes of Acute Respiratory Distress Syndrome Show Prognostic Enrichment in Mechanically Ventilated Patients without Acute Respiratory Distress Syndrome by Heijnen, Nanon F. L., Hagens, Laura A., Smit, Marry R., Cremer, Olaf L., Ong, David S. Y., van der Poll, Tom, van Vught, Lonneke A., Scicluna, Brendon P., Schnabel, Ronny M., van der Horst, Iwan C. C., Schultz, Marcus J., Bergmans, Dennis C. J. J., Bos, Lieuwe D. J., de Beer, Friso M., Bos, Lieuwe D., Glas, Gerie J., Horn, Janneke, Hoogendijk, Arie J., van Hooijdonk, Roosmarijn T., Huson, Mischa A., van der Poll, Tom, Scicluna, Brendon, Schouten, Laura R., Schultz, Marcus J., Straat, Marleen, van Vught, Lonneke A., Wieske, Luuk, Wievel, Maryse A., Witteveen, Esther, Bonten, Marc J., Cremer, Olaf L., Frencken, Jos F., van de Groep, Kirsten, Klein Klouwenberg, Peter M., Koster-Brouwer, Maria E., Ong, David S., Varkila, Meri R., Verboom, Diana M.

“…Heijnen et al discuss their study which aim to determine whether these subphenotypes and their prognostic and potential for predictive enrichment could be…”
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Biomarkers of alveolar epithelial injury and endothelial dysfunction are associated with scores of pulmonary edema in invasively ventilated patients by Atmowihardjo, Leila N, Heijnen, Nanon F L, Smit, Marry R, Hagens, Laura A, Filippini, Daan F L, Zimatore, Claudio, Schultz, Marcus J, Schnabel, Ronny M, Bergmans, Dennis C J J, Aman, Jurjan, Bos, Lieuwe D J

“…Pulmonary edema is a central hallmark of acute respiratory distress syndrome (ARDS). Endothelial dysfunction and epithelial injury contribute to…”
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Comparison of Linear and Sector Array Probe for Handheld Lung Ultrasound in Invasively Ventilated ICU Patients by Smit, Marry R., de Vos, Juliette, Pisani, Luigi, Hagens, Laura A., Almondo, Chiara, Heijnen, Nanon F.L., Schnabel, Ronny M., van der Horst, Iwan C.C., Bergmans, Dennis C.J.J., Schultz, Marcus J., Bos, Lieuwe D.J.

“…International guidelines do not recommend a specific probe for assessment of lung aeration using lung ultrasound (LUS). The aim of this study was to assess the…”
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Boosting the accuracy of existing models by updating and extending: using a multicenter COVID-19 ICU cohort as a proxy by Meijs, Daniek A. M., Wynants, Laure, van Kuijk, Sander M. J., Scheeren, Clarissa I. E., Hana, Anisa, Mehagnoul-Schipper, Jannet, Stessel, Björn, Vander Laenen, Margot, Cox, Eline G. M., Sels, Jan-Willem E. M., Smits, Luc J. M., Bickenbach, Johannes, Mesotten, Dieter, van der Horst, Iwan C. C., Marx, Gernot, van Bussel, Bas C. T.

“…Most published prediction models for Coronavirus Disease 2019 (COVID-19) were poorly reported, at high risk of bias, and heterogeneous in model performance. To…”
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Pulmonary pathophysiology development of COVID-19 assessed by serial Electrical Impedance Tomography in the MaastrICCht cohort by Heines, Serge J. H., van Bussel, Bas C. T., Jong, Melanie J. Acampo-de, Bennis, Frank C., van Gassel, Rob J. J., Groven, Rald V. M., Heijnen, Nanon F. L., Hermans, Ben J. M., Hounjet, René, van Koll, Johan, Mulder, Mark M. G., van de Poll, Marcel C. G., van Rosmalen, Frank, Segers, Ruud, Steyns, Sander, Strauch, Ulrich, Tas, Jeanette, van der Horst, Iwan C. C., van Kuijk, Sander M. J., Bergmans, Dennis C. J. J.

“…Patients with SARS-CoV-2 infection present with different lung compliance and progression of disease differs. Measures of lung mechanics in SARS-CoV-2 patients…”
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Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht) by Tas, Jeanette, van Gassel, Rob J J, Heines, Serge J H, Mulder, Mark M G, Heijnen, Nanon F L, Acampo-de Jong, Melanie J, Bels, Julia L M, Bennis, Frank C, Koelmann, Marcel, Groven, Rald V M, Donkers, Moniek A, van Rosmalen, Frank, Hermans, Ben J M, Meex, Steven JR, Mingels, Alma, Bekers, Otto, Savelkoul, Paul, Oude Lashof, Astrid M L, Wildberger, Joachim, Tijssen, Fabian H, Buhre, Wolfgang, Sels, Jan-Willem E M, Ghossein-Doha, Chahinda, Driessen, Rob G H, Kubben, Pieter L, Janssen, Marcus L F, Nicolaes, Gerry A F, Strauch, Ulrich, Geyik, Zafer, Delnoij, Thijs S R, Walraven, Kim H M, Stehouwer, Coen DA, Verbunt, Jeanine A M C F, Van Mook, Walther N.K.A, van Santen, Susanne, Schnabel, Ronny M, Aries, Marcel J H, van de Poll, Marcel C G, Bergmans, Dennis, van der Horst, Iwan C C, van Kuijk, Sander, van Bussel, Bas C T

“…IntroductionThe course of the disease in SARS-CoV-2 infection in mechanically ventilated patients is unknown. To unravel the clinical heterogeneity of the…”
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Early ICU-mortality in sepsis - causes, influencing factors and variability in clinical judgement: a retrospective cohort study by Driessen, Rob G. H., Heijnen, Nanon F. L., Hulsewe, Riquette P. M. G., Holtkamp, Johanna W. M., Winkens, Bjorn, van de Poll, Marcel C. G., van der Horst, Iwan C. C., Bergmans, Dennis C. J. J., Schnabel, Ronny M.

“…Sepsis is a global health care problem with a high mortality. Early death seems common; however, data are sparse. The objective of the present study was to…”
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Diagnosis of acute respiratory distress syndrome (DARTS) by bedside exhaled breath octane measurements in invasively ventilated patients: protocol of a multicentre observational cohort study by Hagens, Laura A, Heijnen, Nanon F L, Smit, Marry R, Verschueren, Alwin R M, Nijsen, Tamara M E, Geven, Inge, Schultz, Marcus J, Bergmans, Dennis C J J, Schnabel, Ronny M, Bos, Lieuwe D J

“…Acute respiratory distress syndrome (ARDS) is currently diagnosed by the Berlin Definition. Diagnosis is subjective and often late. Untargeted metabolomics…”
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Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study by Fenn, Dominic, Lilien, Thijs A, Hagens, Laura A, Smit, Marry R, Heijnen, Nanon F L, Tuip-de Boer, Anita M, Neerincx, Anne H, Golebski, Korneliusz, Bergmans, Dennis C J J, Schnabel, Ronny M, Schultz, Marcus J, Maitland-van der Zee, Anke H, Brinkman, Paul, Bos, Lieuwe D J

“…Changes in exhaled volatile organic compounds (VOCs) can be used to discriminate between respiratory diseases, and increased concentrations of hydrocarbons are…”
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Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients by Hagens, Laura A., Heijnen, Nanon F.L., Smit, Marry R., Verschueren, Alwin R.M., Nijsen, Tamara M.E., Geven, Inge, Presură, Cristian N., Rietman, Ronald, Fenn, Dominic W., Brinkman, Paul, Schultz, Marcus J., Bergmans, Dennis C.J.J., Schnabel, Ronny M., Bos, Lieuwe D.J.

“…Background The concentration of exhaled octane has been postulated as a reliable biomarker for acute respiratory distress syndrome (ARDS) using metabolomics…”
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