Search Results - "Heijnen, Esther"

Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries by Nguyen-Van-Tam, Jonathan S, O'Leary, Maureen, Martin, Emily T, Heijnen, Esther, Callendret, Benoit, Fleischhackl, Roman, Comeaux, Christy, Tran, Thao Mai Phuong, Weber, Karin

“…Respiratory syncytial virus (RSV) significantly impacts the health of older and high-risk adults (those with comorbidities). We aimed to synthesise the…”
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A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial by Heijnen, Esther MEW, MD, Eijkemans, Marinus JC, PhD, De Klerk, Cora, MSc, Polinder, Suzanne, MSc, Beckers, Nicole GM, MD, Klinkert, Ellen R, MD, Broekmans, Frank J, MD, Passchier, Jan, Prof, Te Velde, Egbert R, Prof, Macklon, Nick S, Prof, Fauser, Bart CJM, Prof

“…Summary Background Mild in-vitro fertilisation (IVF) treatment might lessen both patients' discomfort and multiple births, with their associated risks. We…”
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Immunogenicity of aIIV3, MF59-adjuvanted seasonal trivalent influenza vaccine, in older adults ≥65 years of age: Meta-analysis of cumulative clinical experience by Nicolay, Uwe, Heijnen, Esther, Nacci, Pantaleo, Patriarca, Peter A., Leav, Brett

“…•A meta-analysis of influenza vaccine trials spanning 21 years was conducted.•Antibody responses are significantly higher with aIIV3 than IIV3 in the…”
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Immunogenicity, safety and reactogenicity of Ad26.RSV.preF/RSV preF protein vaccine in adults aged 60 to 75 years: A comparison of phase 2b and phase 3 clinical trial material by Jastorff, Archana, Bastian, Arangassery Rosemary, Ligtenberg, Nynke, Klyashtornyy, Vladislav, Callendret, Benoît, Heijnen, Esther

“…The Ad26.RSV.preF/RSV preF protein vaccine has previously demonstrated efficacyin protecting older adults against respiratory syncytial virus (RSV)-related…”
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Cumulative clinical experience with MF59-adjuvanted trivalent seasonal influenza vaccine in young children and adults 65 years of age and older by Lindert, Kelly, Leav, Brett, Heijnen, Esther, Barrett, Julia, Nicolay, Uwe

“…•Safety of aIIV3 was analyzed with a large clinical trial and surveillance dataset.•aIIV3 and comparator were associated with similar AE rates.•In…”
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MF59-adjuvanted seasonal trivalent inactivated influenza vaccine: Safety and immunogenicity in young children at risk of influenza complications by Patel, Sanjay S., Bizjajeva, Svetlana, Heijnen, Esther, Oberye, Janine

“…•In young children at risk of influenza complications, MF59-adjuvanted trivalent inactivated influenza vaccine (aIIV3) was well-tolerated.•The safety profile…”
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Cumulative clinical experience with MF59-adjuvanted trivalent seasonal influenza vaccine in young children by Patel, Sanjay S., Bizjajeva, Svetlana, Lindert, Kelly, Heijnen, Esther, Oberye, Janine

“…•The immune response to aIIV3 is superior to IIV3 in pediatric subjects (N=11,942).•More children achieve protective HI antibody responses with aIIV3 than with…”
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Immunogenicity and safety of Ad26.RSV.preF/RSV preF protein vaccine at predicted intermediate- and end-of-shelf-life as an evaluation of potency throughout shelf life by Hosman, Tessa, van Heesbeen, Roy, Bastian, Arangassery Rosemary, Hu, Weihong, Comeaux, Christy, Ligtenberg, Nynke, van Montfort, Bart, Callendret, Benoît, Heijnen, Esther

“…This study assessed three Ad26.RSV.preF/RSV preF protein combinations, combining different Ad26.RSV.preF doses and naturally aged preF protein, representing…”
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Predictors of ongoing pregnancy after single-embryo transfer following mild ovarian stimulation for IVF by Verberg, Marieke F.G., M.D, Eijkemans, Marinus J.C., Ph.D, Macklon, Nicholas S., M.D., Ph.D, Heijnen, Esther M.E.W., M.D., Ph.D, Fauser, Bart C.J.M., M.D., Ph.D, Broekmans, Frank J., M.D., Ph.D

“…Objective To develop a prognostic model for the prediction of ongoing pregnancy after single-embryo transfer (SET) following mild stimulation for IVF in women…”
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MF59-adjuvanted influenza vaccine (FLUAD®) elicits higher immune responses than a non-adjuvanted influenza vaccine (Fluzone®): A randomized, multicenter, Phase III pediatric trial in Mexico by Cruz-Valdez, Aurelio, Valdez-Zapata, Gabriel, Patel, Sanjay S., Castelli, Flavia V., Garcia, Marcia G., Jansen, Wim T., Arora, Ashwani Kumar, Heijnen, Esther

“…The poor immune response elicited by trivalent influenza vaccines (TIVs) in children can be enhanced by the addition of adjuvants. This observer-blind,…”
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Evaluation of symptoms in respiratory syncytial virus infection in adults: psychometric evaluation of the Respiratory Infection Intensity and Impact Questionnaire™ symptom scores by Osborne, Richard H., Nelson, Lauren M., Fehnel, Sheri, Williams, Nicole, Bender, Randall H., Ziemiecki, Ryan, Gymnopoulou, Efi, De Paepe, Els, Vandendijck, Yannick, Norcross, Lindsey, Heijnen, Esther, Ispas, Gabriela, Comeaux, Christy, Callendret, Benoit, Chan, Eric K. H., Scott, Jane A.

“…Background The Respiratory Infection Intensity and Impact Questionnaire (RiiQ™) is a patient-reported outcome measure designed to assess symptoms and impacts…”
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Phase 4, Post-Marketing Safety Surveillance of the MF59-Adjuvanted Influenza Vaccines FLUAD® and VANTAFLU® in South Korean Subjects Aged ≥65 Years by Yoo, Byung Wook, Kim, Chang Oh, Izu, Allen, Arora, Ashwani Kumar, Heijnen, Esther

“…Influenza vaccination is recommended for adults aged ≥65 years as they are at high risk of significant morbidity and mortality. This open-label, multicenter,…”
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Safety and Immunogenicity of the Ad26.RSV.preF Investigational Vaccine Coadministered With an Influenza Vaccine in Older Adults by Sadoff, Jerald, De Paepe, Els, Haazen, Wouter, Omoruyi, Edmund, Bastian, Arangassery R, Comeaux, Christy, Heijnen, Esther, Strout, Cynthia, Schuitemaker, Hanneke, Callendret, Benoit

“…Abstract Background Respiratory syncytial virus (RSV) and influenza cause significant disease burden in older adults. Overlapping RSV and influenza seasonality…”
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Efficacy and Safety of an Ad26.RSV.preF–RSV preF Protein Vaccine in Older Adults by Falsey, Ann R., Williams, Kristi, Gymnopoulou, Efi, Bart, Stephan, Ervin, John, Bastian, Arangassery R., Menten, Joris, De Paepe, Els, Vandenberghe, Sjouke, Chan, Eric K.H., Sadoff, Jerald, Douoguih, Macaya, Callendret, Benoit, Comeaux, Christy A., Heijnen, Esther

“…A combination of adenovirus 26 and protein vaccines was used to deliver a prefusion stabilized RSV protein. RSV-related lower respiratory tract illness…”
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Immunogenicity and safety of different dose levels of Ad26.RSV.preF/RSV preF protein vaccine in adults aged 60 years and older: A randomized, double-blind, placebo-controlled, phase 2a study by van Heesbeen, Roy, Bastian, Arangassery Rosemary, Omoruyi, Edmund, Rosen, Jeffrey, Comeaux, Christy A., Callendret, Benoit, Heijnen, Esther

“…Respiratory syncytial virus (RSV) can cause severe illness in older adults. A combination vaccine containing Ad26.RSV.preF and purified recombinant RSV preF…”
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Prevention of Respiratory Syncytial Virus Infection in Healthy Adults by a Single Immunization of Ad26.RSV.preF in a Human Challenge Study by Sadoff, Jerald, De Paepe, Els, DeVincenzo, John, Gymnopoulou, Efi, Menten, Joris, Murray, Bryan, Rosemary Bastian, Arangassery, Vandebosch, An, Haazen, Wouter, Noulin, Nicolas, Comeaux, Christy, Heijnen, Esther, Eze, Kingsley, Gilbert, Anthony, Lambkin-Williams, Rob, Schuitemaker, Hanneke, Callendret, Benoit

“…Abstract Background Respiratory syncytial virus (RSV) is a significant cause of severe lower respiratory tract disease in children and older adults, but has no…”
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Prevention of influenza during mismatched seasons in older adults with an MF59-adjuvanted quadrivalent influenza vaccine: a randomised, controlled, multicentre, phase 3 efficacy study by Beran, Jiří, Reynales, Humberto, Poder, Airi, Yu, Charles Y, Pitisuttithum, Punnee, Yuan, Lee Li, Vermeulen, Wim, Verhoeven, Carole, Leav, Brett, Zhang, Bin, Sawlwin, Daphne, Hamers-Heijnen, Esther, Edelman, Jonathan, Smolenov, Igor

“…The absolute degree of protection from influenza vaccines in older adults has not been studied since 2001. This study aimed to show the clinical efficacy of an…”
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Safety, Immunogenicity, and Regimen Selection of Ad26.RSV.preF–Based Vaccine Combinations: A Randomized, Double-blind, Placebo-Controlled, Phase 1/2a Study by Comeaux, Christy A, Bart, Stephan, Bastian, Arangassery Rosemary, Klyashtornyy, Vladislav, De Paepe, Els, Omoruyi, Edmund, van der Fits, Leslie, van Heesbeen, Roy, Heijnen, Esther, Callendret, Benoit, Sadoff, Jerald

“…Abstract Background Ad26.RSV.preF is an adenovirus serotype 26 vector–based respiratory syncytial virus (RSV) vaccine encoding a prefusion…”
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Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment by Custers, Jerome, Kim, Denny, Leyssen, Maarten, Gurwith, Marc, Tomaka, Frank, Robertson, James, Heijnen, Esther, Condit, Richard, Shukarev, Georgi, Heerwegh, Dirk, van Heesbeen, Roy, Schuitemaker, Hanneke, Douoguih, Macaya, Evans, Eric, Smith, Emily R., Chen, Robert T.

“…Replication-incompetent adenoviral vectors have been under investigation as a platform to carry a variety of transgenes, and express them as a basis for…”
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Concomitant Administration of Ad26.RSV.preF/RSV preF Protein Vaccine and High-Dose Influenza Vaccine in Adults 65 Years and Older: A Noninferiority Trial by Widagdo, Widagdo, Bastian, Arangassery Rosemary, Jastorff, Archana M, Scheys, Ilse, De Paepe, Els, Comeaux, Christy A, Ligtenberg, Nynke, Callendret, Benoit, Heijnen, Esther

“…Abstract Background Since influenza and respiratory syncytial virus (RSV) carry significant burden in older adults with overlapping seasonality, vaccines for…”
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