Search Results - "Heijn, M"

Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions by LEE, Chang-Geol, HEIJN, Marcus, BOUCHER, Yves, DI TOMASO, Emmanuelle, GRIFFON-ETIENNE, Genevieve, ANCUKIEWICZ, M, KOIKE, Chieko, PARK, K. R, FERRARA, Napoleone, JAIN, Rakesh K, SUIT, Herman D

“…Recent studies in experimental animals have shown that combining antiangiogenic therapy with radiation can enhance tumor response. Whether this enhancement is…”
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Specific detection of multidrug resistance proteins mrp1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies by SCHEFFER, George L, KOOL, Marcel, VAN DER LINDEN, Marcel, DE VREE, J. Marleen L, VAN DER VALK, Paul, ELFERINK, Ronald P. J. Oude, BORST, Piet, SCHEPER, Rik J, HEIJN, Marc, DE HAAS, Marcel, PIJNENBORG, Adriana C. L. M, WIJNHOLDS, Jan, VAN HELVOORT, Ardy, DE JONG, Mariska C, HOOIJBERG, Jan H, MOL, Carla A. A. M

“…Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1…”
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Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein by Hooijberg, J.H, Broxterman, H.J, Heijn, M, Fles, D.L.A, Lankelma, J, Pinedo, H.M

“…The multidrug resistance protein (MRP) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In…”
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Potent interaction of flavopiridol with MRP1 by HOOIJBERG, J. H, BROXTERMAN, H. J, SCHEFFER, G. L, VRASDONK, C, HEIJN, M, DE JONG, M. C, SCHEPER, R. J, LANKELMA, J, PINEDO, H. M

“…The multidrug resistance protein 1 (MRP1) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents…”
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ATP-dependent multispecific organic anion transport system in rat erythrocyte membrane vesicles by Heijn, M, Oude Elferink, R P, Jansen, P L

“…The uptake of oxidized glutathione (GSSG) into inside-out membrane vesicles of Wistar rat erythrocytes was studied. Uptake was ATP dependent, into an…”
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The protective effect of cardiac gene transfer of CuZn-sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells by Abou El Hassan, M A I, Heijn, M, Rabelink, M J W E, van der Vijgh, W J F, Bast, A, Hoeben, R C

“…Doxorubicin-induced cardiotoxicity is related to its production of free radicals that specifically affect heart tissue because of its low antioxidant status…”
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Re: How Does the MRP/GS-X Pump Export Doxorubicin? by BROXTERMAN, HENK J., HEIJN, MARC, LANKELMA, JAN

“…Broxterman and others comment on the role that the multidrug resistance protein/glutathione S-conjugates play in the transport of the cationic lipophilic drug…”
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Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione by Paulusma, C C, van Geer, M A, Evers, R, Heijn, M, Ottenhoff, R, Borst, P, Oude Elferink, R P

“…The canalicular multispecific organic anion transporter (cMOAT), a member of the ATP-binding cassette transporter family, mediates the transport of a broad…”
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A doxorubicin–CNGRC-peptide conjugate with prodrug properties by van Hensbergen, Yvette, Broxterman, Henk J., Elderkamp, Yvonne W., Lankelma, Jan, Beers, Judith C.C., Heijn, Marc, Boven, Epie, Hoekman, Klaas, Pinedo, Herbert M.

“…There is increasing interest in the exploitation of molecular addresses for the targeting of tumor imaging or therapeutic agents. A recent study demonstrated…”
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Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport by Heijn, Marc, Hooijberg, Jan H, Scheffer, George L, Szabó, Gabór, Westerhoff, Hans V, Lankelma, Jan

“…We studied the ATP-dependent uptake of dinitrophenyl-glutathione (GS-DNP) into plasma membrane vesicles derived from parental GLC4 cells and from multidrug…”
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Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor by HEIJN, M, ROBERGE, S, JAIN, R. K

“…The clearance of anthracyclines from the vasculature was studied in perfused tissue-isolated tumors. Human tumor lines MCF-7, U87, and LS174T were implanted in…”
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A Method for Studying Plasma Membrane Transport with Intact Cells Using Computerized Fluorometry by Wielinga, Peter R., Heijn, Marc, Westerhoff, Hans V., Lankelma, Jan

“…A new method is presented for measuring rapid efflux of fluorescent compounds from monolayer cells. Cells grown on a glass coverslip were loaded with a…”
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Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes by Roelofsen, H, Bakker, C T, Schoemaker, B, Heijn, M, Jansen, P L, Elferink, R P

“…The hepatocanalicular transport of a large number of organic anions, such as bilirubin glucuronides and glutathione conjugates in the rat, is mediated by an…”
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P-glycoprotein-independent decrease in drug accumulation by phorbol ester treatment of tumor cells by Wielinga, Peter R, Heijn, Marc, Broxterman, Henk J, Lankelma, Jan

“…The effect of a change in the phosphorylation state of the drug transporter P-glycoprotein (P-gp) on its drug transport activity was studied for the substrates…”
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Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter by Oude Elferink, R P, Bakker, C T, Roelofsen, H, Middelkoop, E, Ottenhoff, R, Heijn, M, Jansen, P L

“…Transport of organic anions within hepatocytes and the possible involvement of intracellular vesicles were studied with fluorescence microscopy. For this…”
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Na+ and H+ gradient-dependent transport of p-aminohippurate in membrane vesicles from dog kidney cortex by Russel, F G, van der Linden, P E, Vermeulen, W G, Heijn, M, van Os, C H, van Ginneken, C A

“…The transport of p-aminohippurate (PAH) was studied in basolateral (BLMV) and brush border membrane vesicles (BBMV) isolated from dog kidney cortex. Imposition…”
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Effect of substituted benzoates on p-aminohippurate transport in dog renal membrane vesicles by RUSSEL, F. G. M, HEIJN, M, DE LAET, R. C, VAN GINNEKEN, C. A. M

“…The effect of substituted benzoates on the transport of p-aminohippurate (PAH) was studied in basolateral (BLMV) and brush border membrane vesicles (BBMV)…”
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