Search Results - "Heijer, Tom den"
-
1
Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study
Published in Annals of neurology (01-06-2005)“…Cerebral blood flow (CBF) velocity is decreased in patients with Alzheimer's disease. It is being debated whether this reflects diminished demand because of…”
Get full text
Journal Article -
2
Brain tissue volumes in relation to cognitive function and risk of dementia
Published in Neurobiology of aging (01-03-2010)“…Abstract We investigated in a population-based cohort study the association of global and lobar brain tissue volumes with specific cognitive domains and risk…”
Get full text
Journal Article -
3
Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia
Published in Neurology (26-02-2013)“…We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of…”
Get full text
Journal Article -
4
Total antioxidant capacity of the diet and major neurologic outcomes in older adults
Published in Neurology (05-03-2013)“…To evaluate total antioxidant capacity of the diet, measured by the ferric-reducing antioxidant power (FRAP) assay, in relation to risks of dementia and…”
Get full text
Journal Article -
5
Association between blood pressure levels over time and brain atrophy in the elderly
Published in Neurobiology of aging (01-03-2003)“…The relation between blood pressure level and degree of global brain atrophy is equivocal. We evaluated past and present blood pressure levels and change in…”
Get full text
Journal Article -
6
Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia
Published in Neurology (08-07-2014)“…OBJECTIVE:We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large…”
Get full text
Journal Article -
7
Hippocampus segmentation in MR images using atlas registration, voxel classification, and graph cuts
Published in NeuroImage (Orlando, Fla.) (01-12-2008)“…Since hippocampal volume has been found to be an early biomarker for Alzheimer's disease, there is large interest in automated methods to accurately, robustly,…”
Get full text
Journal Article -
8
Presymptomatic cognitive decline in familial frontotemporal dementia: A longitudinal study
Published in Neurology (26-07-2016)“…OBJECTIVE:In this prospective cohort study, we performed a 2-year follow-up study with neuropsychological assessment in the presymptomatic phase of familial…”
Get full text
Journal Article -
9
Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Published in The New England journal of medicine (27-03-2003)“…Silent brain infarcts (i.e., infarcts without associated neurologic symptoms) are common, and their clinical significance is unclear. In this population-based…”
Get full text
Journal Article -
10
Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study
Published in Stroke (1970) (01-02-2003)“…The prevalence of silent brain infarcts in healthy elderly people is high, and these lesions are associated with an increased risk of stroke. The incidence of…”
Get full text
Journal Article -
11
A Study of the Bidirectional Association Between Hippocampal Volume on Magnetic Resonance Imaging and Depression in the Elderly
Published in Biological psychiatry (1969) (15-07-2011)“…Background Hippocampal volume loss on magnetic resonance imaging (MRI) has been reported in patients with depression. It is uncertain whether a small…”
Get full text
Journal Article -
12
LONGITUDINAL MULTIMODAL NEUROIMAGING IN PRESYMPTOMATIC FRONTOTEMPORAL DEMENTIA: PREDICTING SYMPTOM ONSET IN THE DUTCH FTD RISK COHORT
Published in Alzheimer's & dementia (01-07-2017)Get full text
Journal Article -
13
Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study
Published in NeuroImage clinical (01-01-2016)“…Frontotemporal dementia (FTD) is characterized by behavioral disturbances and language problems. Familial forms can be caused by genetic defects in…”
Get full text
Journal Article -
14
The Association of Polymorphisms in the Type 1 and 2 Deiodinase Genes with Circulating Thyroid Hormone Parameters and Atrophy of the Medial Temporal Lobe
Published in The journal of clinical endocrinology and metabolism (01-02-2007)“…Context: Thyroid function has been related to Alzheimer disease (AD) and neuroimaging markers thereof. Whether thyroid dysfunction contributes to or results…”
Get full text
Journal Article -
15
Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia
Published in The American journal of clinical nutrition (01-10-2004)“…Consumers of light-to-moderate amounts of alcohol have a lower risk of dementia and, possibly, Alzheimer disease than do abstainers. Because vascular disease…”
Get full text
Journal Article -
16
The thyroid hormone receptor alpha locus and white matter lesions: a role for the clock gene REV-ERBα
Published in Thyroid (New York, N.Y.) (01-11-2012)“…Thyroid disorders are associated with an increased risk of cognitive impairment and Alzheimer's disease. Both small vessel disease and neurodegeneration have a…”
Get more information
Journal Article -
17
Cerebral haemodynamics in the elderly: the rotterdam study
Published in Neuroepidemiology (01-07-2004)“…Transcranial Doppler ultrasonography allows the non-invasive assessment of cerebral haemodynamics. Data on the frequency distribution of these parameters in…”
Get more information
Journal Article -
18
ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala
Published in Neurobiology of aging (01-08-2005)“…Despite biological support for a role of angiotensin converting enzyme (ACE) in Alzheimer's disease (AD), studies assessing the ACE I/D polymorphism in AD are…”
Get full text
Journal Article -
19
Cerebral white matter lesions and the risk of dementia
Published in Archives of neurology (Chicago) (01-10-2004)“…To study the association between white matter lesions (WML) in specific locations and the risk of dementia. The Rotterdam Scan Study, a prospective…”
Get more information
Journal Article -
20
Matrix metalloproteinase 3 haplotypes and dementia and Alzheimer's disease. The Rotterdam Study
Published in Neurobiology of aging (01-06-2008)“…Evidence by post-mortem and animal studies suggests that matrix metalloproteinases (MMPs) may play an important role in the pathophysiology of Alzheimer's…”
Get full text
Journal Article