Search Results - "Heier, Christoph"

Triacylglycerol Metabolism in Drosophila melanogaster by Heier, Christoph, Kühnlein, Ronald P

“…Triacylglycerol (TAG) is the most important caloric source with respect to energy homeostasis in animals. In addition to its evolutionarily conserved…”
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Nonoxidative ethanol metabolism in humans—from biomarkers to bioactive lipids by Heier, Christoph, Xie, Hao, Zimmermann, Robert

“…Ethanol is a widely used psychoactive drug whose chronic abuse is associated with organ dysfunction and disease. Although the prevalent metabolic fate of…”
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Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation by Kien, Benedikt, Kolleritsch, Stephanie, Kunowska, Natalia, Heier, Christoph, Chalhoub, Gabriel, Tilp, Anna, Wolinski, Heimo, Stelzl, Ulrich, Haemmerle, Guenter

“…Disturbances in lipid homeostasis can cause mitochondrial dysfunction and lipotoxicity. Perilipin 5 (PLIN5) decorates intracellular lipid droplets (LDs) in…”
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Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase by Padmanabha Das, Krishna M., Wechselberger, Lisa, Liziczai, Márton, De la Rosa Rodriguez, Montserrat, Grabner, Gernot F., Heier, Christoph, Viertlmayr, Roland, Radler, Claudia, Lichtenegger, Jörg, Zimmermann, Robert, Borst, Jan Willem, Zechner, Rudolf, Kersten, Sander, Oberer, Monika

“…Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis…”
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The Patatin-Like Phospholipase Domain Containing Protein 7 Regulates Macrophage Classical Activation through SIRT1/NF-κB and p38 MAPK Pathways by Zhao, Zheng, Heier, Christoph, Pang, Huimin, Wang, Yu, Huang, Feifei, Chang, Pingan

“…Lysophosphatidylcholine (LPC) is a bioactive lipid that modulates macrophage polarization during immune responses, inflammation, and tissue remodeling…”
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Cooperative lipolytic control of neuronal triacylglycerol by spastic paraplegia-associated enzyme DDHD2 and ATGL by Hofer, Peter, Grabner, Gernot F., König, Mario, Xie, Hao, Bulfon, Dominik, Ludwig, Anton E., Wolinski, Heimo, Zimmermann, Robert, Zechner, Rudolf, Heier, Christoph

“…Intracellular lipolysis – the enzymatic breakdown of lipid droplet (LD)-associated triacylglycerols (TAGs) – depends on the cooperative action of several…”
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Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success by Heier, Christoph, Knittelfelder, Oskar, Hofbauer, Harald F, Mende, Wolfgang, Pörnbacher, Ingrid, Schiller, Laura, Schoiswohl, Gabriele, Xie, Hao, Grönke, Sebastian, Shevchenko, Andrej, Kühnlein, Ronald P

“…Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and…”
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Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice by Kolleritsch, Stephanie, Kien, Benedikt, Schoiswohl, Gabriele, Diwoky, Clemens, Schreiber, Renate, Heier, Christoph, Maresch, Lisa Katharina, Schweiger, Martina, Eichmann, Thomas O, Stryeck, Sarah, Krenn, Petra, Tomin, Tamara, Schittmayer, Matthias, Kolb, Dagmar, Rülicke, Thomas, Hoefler, Gerald, Wolinski, Heimo, Madl, Tobias, Birner-Gruenberger, Ruth, Haemmerle, Guenter

“…Abstract Aims Lipotoxic cardiomyopathy in diabetic and obese patients typically encompasses increased cardiac fatty acid (FA) uptake eventually surpassing the…”
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Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance by Taschler, Ulrike, Radner, Franz P.W., Heier, Christoph, Schreiber, Renate, Schweiger, Martina, Schoiswohl, Gabriele, Preiss-Landl, Karina, Jaeger, Doris, Reiter, Birgit, Koefeler, Harald C., Wojciechowski, Jacek, Theussl, Christian, Penninger, Josef M., Lass, Achim, Haemmerle, Guenter, Zechner, Rudolf, Zimmermann, Robert

“…Monoglyceride lipase (MGL) influences energy metabolism by at least two mechanisms. First, it hydrolyzes monoacylglycerols (MG) into fatty acids and glycerol…”
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Interaction of the Lysophospholipase PNPLA7 with Lipid Droplets through the Catalytic Region by Chang, Pingan, Sun, Tengteng, Heier, Christoph, Gao, Hao, Xu, Hongmei, Huang, Feifei

“…Mammalian patatin-like phospholipase domain containing proteins (PNPLAs) play critical roles in triglyceride hydrolysis, phospholipids metabolism, and lipid…”
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Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila by Xu, Yanjun, Borcherding, Annika F., Heier, Christoph, Tian, Gu, Roeder, Thomas, Kühnlein, Ronald P.

“…Obesity is a progressive, chronic disease, which can be caused by long-term miscommunication between organs. It remains challenging to understand how chronic…”
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Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier[S] by Pollak, Nina M., Schweiger, Martina, Jaeger, Doris, Kolb, Dagmar, Kumari, Manju, Schreiber, Renate, Kolleritsch, Stephanie, Markolin, Philipp, Grabner, Gernot F., Heier, Christoph, Zierler, Kathrin A., Rülicke, Thomas, Zimmermann, Robert, Lass, Achim, Zechner, Rudolf, Haemmerle, Guenter

“…Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is…”
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Molecular identification of transmembrane protein 68 as an endoplasmic reticulum-anchored and brain-specific protein by Chang, Ping'an, Heier, Christoph, Qin, Wenzhen, Han, Liping, Huang, Feifei, Sun, Quan

“…Acyltransferases catalyze essential reactions in the buildup and remodeling of glycerophospholipids and contribute to the maintenance and diversity of cellular…”
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Hypoxia-inducible Lipid Droplet-associated (HILPDA) Is a Novel Peroxisome Proliferator-activated Receptor (PPAR) Target Involved in Hepatic Triglyceride Secretion by Mattijssen, Frits, Georgiadi, Anastasia, Andasarie, Tresty, Szalowska, Ewa, Zota, Annika, Krones-Herzig, Anja, Heier, Christoph, Ratman, Dariusz, De Bosscher, Karolien, Qi, Ling, Zechner, Rudolf, Herzig, Stephan, Kersten, Sander

“…Peroxisome proliferator-activated receptors (PPARs) play major roles in the regulation of hepatic lipid metabolism through the control of numerous genes…”
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The α/β-hydrolase domain-containing 4- and 5-related phospholipase Pummelig controls energy storage in Drosophila by Hehlert, Philip, Hofferek, Vinzenz, Heier, Christoph, Eichmann, Thomas O., Riedel, Dietmar, Rosenberg, Jonathan, Takaćs, Anna, Nagy, Harald M., Oberer, Monika, Zimmermann, Robert, Kühnlein, Ronald P.

“…Triglycerides (TGs) are the main energy storage form that accommodates changing organismal energy demands. In Drosophila melanogaster, the TG lipase Brummer is…”
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ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6 by Eichmann, Thomas O., Grumet, Lukas, Taschler, Ulrike, Hartler, Jürgen, Heier, Christoph, Woblistin, Aaron, Pajed, Laura, Kollroser, Manfred, Rechberger, Gerald, Thallinger, Gerhard G., Zechner, Rudolf, Haemmerle, Günter, Zimmermann, Robert, Lass, Achim

“…Lipid droplets (LDs) of hepatic stellate cells (HSCs) contain large amounts of vitamin A [in the form of retinyl esters (REs)] as well as other neutral lipids…”
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The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome by Thomas, Gwynneth, Betters, Jenna L., Lord, Caleb C., Brown, Amanda L., Marshall, Stephanie, Ferguson, Daniel, Sawyer, Janet, Davis, Matthew A., Melchior, John T., Blume, Lawrence C., Howlett, Allyn C., Ivanova, Pavlina T., Milne, Stephen B., Myers, David S., Mrak, Irina, Leber, Vera, Heier, Christoph, Taschler, Ulrike, Blankman, Jacqueline L., Cravatt, Benjamin F., Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Zimmermann, Robert, Brown, H. Alex, Brown, J. Mark

“…The serine hydrolase α/β hydrolase domain 6 (ABHD6) has recently been implicated as a key lipase for the endocannabinoid 2-arachidonylglycerol (2-AG) in the…”
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Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis by Tang, Zhiyuan, Xie, Hao, Heier, Christoph, Huang, Jianfei, Zheng, Qiuling, Eichmann, Thomas O., Schoiswohl, Gabriele, Ni, Jun, Zechner, Rudolf, Ni, Songshi, Hao, Haiping

“…Tumor cells display metabolic changes that correlate with malignancy, including an elevated hydrolysis of monoacylglycerol (MAG) in various cancer types…”
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G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis by Heier, Christoph, Radner, Franz P.W., Moustafa, Tarek, Schreiber, Renate, Grond, Susanne, Eichmann, Thomas O., Schweiger, Martina, Schmidt, Albrecht, Cerk, Ines K., Oberer, Monika, Theussl, H.-Christian, Wojciechowski, Jacek, Penninger, Josef M., Zimmermann, Robert, Zechner, Rudolf

“…The anabolism and catabolism of myocardial triacylglycerol (TAG) stores are important processes for normal cardiac function. TAG synthesis detoxifies and…”
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Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging by Hänschke, Lea, Heier, Christoph, Maya Palacios, Santiago José, Özek, Huseyin Erdem, Thiele, Christoph, Bauer, Reinhard, Kühnlein, Ronald P., Bülow, Margret H.

“…The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency…”
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