Search Results - "Heidorn, Sonja"

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF by Heidorn, Sonja J., Milagre, Carla, Whittaker, Steven, Nourry, Arnaud, Niculescu-Duvas, Ion, Dhomen, Nathalie, Hussain, Jahan, Reis-Filho, Jorge S., Springer, Caroline J., Pritchard, Catrin, Marais, Richard

“…We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive…”
Get full text

Raf Inhibitors Target Ras Spatiotemporal Dynamics by Cho, Kwang-jin, Kasai, Rinshi S., Park, Jin-Hee, Chigurupati, Sravanthi, Heidorn, Sonja J., van der Hoeven, Dharini, Plowman, Sarah J., Kusumi, Akihiro, Marais, Richard, Hancock, John F.

“…The lateral segregation of Ras proteins into transient plasma membrane nanoclusters is essential for high-fidelity signal transmission by the Ras…”
Get full text

Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia by Packer, Leisl M., Rana, Sareena, Hayward, Robert, O'Hare, Thomas, Eide, Christopher A., Rebocho, Ana, Heidorn, Sonja, Zabriskie, Matthew S., Niculescu-Duvaz, Ion, Druker, Brian J., Springer, Caroline, Marais, Richard

“…We show that imatinib, nilotinib, and dasatinib possess weak off-target activity against RAF and, therefore, drive paradoxical activation of BRAF and CRAF in a…”
Get full text