Search Results - "Heideman, Marinus R."

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis by Wilting, Roel H, Yanover, Eva, Heideman, Marinus R, Jacobs, Heinz, Horner, James, van der Torre, Jaco, DePinho, Ronald A, Dannenberg, Jan-Hermen

“…Histone deacetylases (HDACs) counterbalance acetylation of lysine residues, a protein modification involved in numerous biological processes. Here, Hdac1 and…”
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Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis by Heideman, Marinus R, Lancini, Cesare, Proost, Natalie, Yanover, Eva, Jacobs, Heinz, Dannenberg, Jan-Hermen

“…Class I histone deacetylases are critical regulators of gene transcription by erasing lysine acetylation. Targeting histone deacetylases using relative…”
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Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models by Issa, Amine, Gill, Jason W, Heideman, Marinus R, Sahin, Ozgur, Wiemann, Stefan, Dey, Julien H, Hynes, Nancy E

“…Targeting receptor tyrosine kinases (RTKs) with kinase inhibitors is a clinically validated anti-cancer approach. However, blocking one signaling pathway is…”
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Defining chromosomal translocation risks in cancer by Hogenbirk, Marc A., Heideman, Marinus R., de Rink, Iris, Velds, Arno, Kerkhoven, Ron M., Wessels, Lodewyk F. A., Jacobs, Heinz

“…Chromosomal translocations are a hallmark of cancer. Unraveling the molecular mechanism of these rare genetic events requires a clear distinction between…”
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Differential programming of B cells in AID deficient mice by Hogenbirk, Marc A, Heideman, Marinus R, Velds, Arno, van den Berk, Paul C M, Kerkhoven, Ron M, van Steensel, Bas, Jacobs, Heinz

“…The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic…”
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Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production by Lutz, Johannes, Heideman, Marinus R, Roth, Edith, van den Berk, Paul, Müller, Werner, Raman, Chander, Wabl, Matthias, Jacobs, Heinz, Jäck, Hans-Martin

“…B-lymphocyte development is dictated by the protein products of functionally rearranged Ig heavy (H) and light (L) chain genes. Ig rearrangement begins in…”
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Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function by Heideman, Marinus R., Wilting, Roel H., Yanover, Eva, Velds, Arno, de Jong, Johann, Kerkhoven, Ron M., Jacobs, Heinz, Wessels, Lodewyk F., Dannenberg, Jan-Hermen

“…Histone deacetylases (HDACs) are epigenetic erasers of lysine-acetyl marks. Inhibition of HDACs using small molecule inhibitors (HDACi) is a potential strategy…”
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Histone deacetylase 1 plays a predominant pro-oncogenic role in Eμ-myc driven B cell lymphoma by Pillonel, Vincent, Reichert, Nina, Cao, Chun, Heideman, Marinus R., Yamaguchi, Teppei, Matthias, Gabriele, Tzankov, Alexandar, Matthias, Patrick

“…The two histone deacetylases (Hdacs), Hdac1 and Hdac2, are erasers of acetylation marks on histone tails, and are important regulators of gene expression that…”
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Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice by Langerak, Petra, Krijger, Peter H.L, Heideman, Marinus R, van den Berk, Paul C.M, Jacobs, Heinz

“…knock-in mice. A 10-fold reduction in A/T mutations is associated with a compensatory increase in G/C mutations—a phenotype similar to Polη and mismatch…”
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Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages by Smirnova, Tatiana, Bonapace, Laura, MacDonald, Gwen, Kondo, Shunya, Wyckoff, Jeffrey, Ebersbach, Hilmar, Fayard, Bérengère, Doelemeyer, Arno, Coissieux, Marie-May, Heideman, Marinus R, Bentires-Alj, Mohamed, Hynes, Nancy E

“…The extracellular serine protease inhibitor serpinE2 is overexpressed in breast cancer and has been shown to foster metastatic spread. Here, we investigated…”
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Targeting a Novel ER/HOXB7 Signaling Loop in Tamoxifen-Resistant Breast Cancer by Heideman, Marinus R, Frei, Anna, Hynes, Nancy E

“…The majority of patients with breast cancer present with an estrogen receptor-positive (ER(+)) tumor, and the endocrine agent tamoxifen is a mainstay for their…”
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AXL/epidermal growth factor receptor (EGFR) complexes in breast cancer--culprits for resistance to EGFR inhibitors? by Heideman, Marinus R, Hynes, Nancy E

“…Epidermal growth factor receptor (EGFR) is highly expressed in triple-negative breast cancer (TNBC), and elevated levels correlate with poor prognosis. In…”
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Elevated APOBEC3B Correlates with Poor Outcomes for Estrogen-Receptor-Positive Breast Cancers by Sieuwerts, Anieta M., Willis, Scooter, Burns, Michael B., Look, Maxime P., Gelder, Marion E. Meijer-Van, Schlicker, Andreas, Heideman, Marinus R., Jacobs, Heinz, Wessels, Lodewyk, Leyland-Jones, Brian, Gray, Kathryn P., Foekens, John A., Harris, Reuben S., Martens, John W. M.

“…Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic evolution of breast cancer. We addressed whether APOBEC3B is associated with…”
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The (I/Y)XGG Motif of Adenovirus DNA Polymerase Affects Template DNA Binding and the Transition from Initiation to Elongation by Brenkman, Arjan B., Heideman, Marinus R., Truniger, Veronica, Salas, Margarita, van der Vliet, Peter C.

“…Adenovirus DNA polymerase (Ad pol) is a eukaryotic-type DNA polymerase involved in the catalysis of protein-primed initiation as well as DNA polymerization…”
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Histone deacetylase 1 plays a predominant pro-oncogenic role in E[mu]-myc driven B cell lymphoma by Pillonel, Vincent, Reichert, Nina, Cao, Chun, Heideman, Marinus R, Yamaguchi, Teppei, Matthias, Gabriele, Tzankov, Alexandar, Matthias, Patrick

“…The two histone deacetylases (Hdacs), Hdac1 and Hdac2, are erasers of acetylation marks on histone tails, and are important regulators of gene expression that…”
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Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen K164R mutant mice by Langerak, Petra, Krijger, Peter H.L, Heideman, Marinus R, van den Berk, Paul C.M, Jacobs, Heinz

“…Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a…”
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Somatic Hypermutation of Immunoglobulin Genes: Lessons from Proliferating Cell Nuclear${\text{Antigen}}^{K164R} $Mutant Mice by Langerak, Petra, Krijger, Peter H. L., Heideman, Marinus R., van den Berk, Paul C. M., Jacobs, Heinz

“…Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a…”
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Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen super(K164R) mutant mice by Langerak, Petra, Krijger, Peter HL, Heideman, Marinus R, Van den Berk, Paul CM, Jacobs, Heinz

“…Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a…”
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Differential Programming of B Cells in AID Deficient Mice. e69815 by Hogenbirk, Marc A, Heideman, Marinus R, Velds, Arno, Berk, CM vanden, Kerkhoven, Ron M, Steensel, Bas van, Jacobs, Heinz

“…The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic…”
Get full text