Search Results - "Heidbuechel, Johannes P. W"

Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies by Heidbuechel, Johannes P W, Engeland, Christine E

“…Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against…”
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Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17 by Müller, Miryam, Saunders, Claire, Senftleben, Anke, Heidbuechel, Johannes P. W, Halwachs, Birgit, Bolik, Julia, Hedemann, Nina, Röder, Christian, Bauerschlag, Dirk, Rose-John, Stefan, Schmidt-Arras, Dirk

“…Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family…”
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Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors by Speck, Tobias, Heidbuechel, Johannes P W, Veinalde, Rūta, Jaeger, Dirk, von Kalle, Christof, Ball, Claudia R, Ungerechts, Guy, Engeland, Christine E

“…Immunotherapy with bispecific T-cell engagers has achieved striking success against hematologic malignancies, but efficacy against solid tumors has been…”
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Measles Vaccines Designed for Enhanced CD8 + T Cell Activation by Busch, Elena, Kubon, Kristina D, Mayer, Johanna K M, Pidelaserra-Martí, Gemma, Albert, Jessica, Hoyler, Birgit, Heidbuechel, Johannes P W, Stephenson, Kyle B, Lichty, Brian D, Osen, Wolfram, Eichmüller, Stefan B, Jäger, Dirk, Ungerechts, Guy, Engeland, Christine E

“…Priming and activation of CD8 T cell responses is crucial to achieve anti-viral and anti-tumor immunity. Live attenuated measles vaccine strains have been used…”
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Fighting Cancer with Mathematics and Viruses by Santiago, Daniel N, Heidbuechel, Johannes P W, Kandell, Wendy M, Walker, Rachel, Djeu, Julie, Engeland, Christine E, Abate-Daga, Daniel, Enderling, Heiko

“…After decades of research, oncolytic virotherapy has recently advanced to clinical application, and currently a multitude of novel agents and combination…”
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Mathematical Modeling of Oncolytic Virotherapy by Heidbuechel, Johannes P W, Abate-Daga, Daniel, Engeland, Christine E, Enderling, Heiko

“…Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A…”
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo by Heidbuechel, Johannes P W, Engeland, Christine E

“…Successful cancer immunotherapy has the potential to achieve long-term tumor control. Despite recent clinical successes, there remains an urgent need for safe…”
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