Search Results - "Heid, Iris M."

A Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography by Grassmann, Felix, Mengelkamp, Judith, Brandl, Caroline, Harsch, Sebastian, Zimmermann, Martina E., Linkohr, Birgit, Peters, Annette, Heid, Iris M., Palm, Christoph, Weber, Bernhard H.F.

“…Age-related macular degeneration (AMD) is a common threat to vision. While classification of disease stages is critical to understanding disease risk and…”
Get full text

Quantification of the overall contribution of gene-environment interaction for obesity-related traits by Sulc, Jonathan, Mounier, Ninon, Günther, Felix, Winkler, Thomas, Wood, Andrew R., Frayling, Timothy M., Heid, Iris M., Robinson, Matthew R., Kutalik, Zoltán

“…The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum…”
Get full text

EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data by Winkler, Thomas W, Kutalik, Zoltan, Gorski, Mathias, Lottaz, Claudio, Kronenberg, Florian, Heid, Iris M

“…The R package EasyStrata facilitates the evaluation and visualization of stratified genome-wide association meta-analyses (GWAMAs) results. It provides (i)…”
Get full text

A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications by Winkler, Thomas W, Günther, Felix, Höllerer, Simon, Zimmermann, Martina, Loos, Ruth JF, Kutalik, Zoltán, Heid, Iris M

“…The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here,…”
Get full text

Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study by Brandl, Caroline, Brücklmayer, Christiane, Günther, Felix, Zimmermann, Martina E, Küchenhoff, Helmut, Helbig, Horst, Weber, Bernhard H F, Heid, Iris M, Stark, Klaus J

“…To systematically analyze thicknesses of retinal layers in an older population and their link to early age-related macular degeneration (AMD). In the AugUR…”
Get full text

KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies by Stanzick, Kira J, Stark, Klaus J, Gorski, Mathias, Schödel, Johannes, Krüger, René, Kronenberg, Florian, Warth, Richard, Heid, Iris M, Winkler, Thomas W

“…Abstract Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these…”
Get full text

Nocturnal hypoxemic burden and micro- and macrovascular disease in patients with type 2 diabetes by Driendl, Sarah, Stadler, Stefan, Arzt, Michael, Zeman, Florian, Heid, Iris M, Baumert, Mathias

“…Micro- and macrovascular diseases are common in patients with type 2 diabetes mellitus (T2D) and may be partly caused by nocturnal hypoxemia. The study aimed…”
Get full text

Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral Blood by Koller, Adriana, Lamina, Claudia, Brandl, Caroline, Zimmermann, Martina E., Stark, Klaus J., Weissensteiner, Hansi, Würzner, Reinhard, Heid, Iris M., Kronenberg, Florian

“…Mitochondrial dysfunction is a common occurrence in the aging process and is observed in diseases such as age-related macular degeneration (AMD). Increased…”
Get full text

Genome wide association study and genomic risk prediction of age related macular degeneration in Israel by Grunin, Michelle, Triffon, Daria, Beykin, Gala, Rahmani, Elior, Schweiger, Regev, Tiosano, Liran, Khateb, Samer, Hagbi-Levi, Shira, Rinsky, Batya, Munitz, Refael, Winkler, Thomas W., Heid, Iris M., Halperin, Eran, Carmi, Shai, Chowers, Itay

“…The risk of developing age-related macular degeneration (AMD) is influenced by genetic background. In 2016, the International AMD Genomics Consortium (IAMDGC)…”
Get full text

DNA extraction from clotted blood in genotyping quality by Stanzick, Kira J, Simon, Josef, Zimmermann, Martina E, Schachtner, Michael, Peterhoff, David, Niller, Hans-Helmut, Überla, Klaus, Wagner, Ralf, Heid, Iris M, Stark, Klaus J

“…DNA extraction from frozen blood clots is challenging. Here, the authors applied QIAGEN Clotspin Baskets and the Gentra Puregene Blood Kit for DNA extraction…”
Get full text

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease by Winkler, Thomas W, Grassmann, Felix, Brandl, Caroline, Kiel, Christina, Günther, Felix, Strunz, Tobias, Weidner, Lorraine, Zimmermann, Martina E, Korb, Christina A, Poplawski, Alicia, Schuster, Alexander K, Müller-Nurasyid, Martina, Peters, Annette, Rauscher, Franziska G, Elze, Tobias, Horn, Katrin, Scholz, Markus, Cañadas-Garre, Marisa, McKnight, Amy Jayne, Quinn, Nicola, Hogg, Ruth E, Küchenhoff, Helmut, Heid, Iris M, Stark, Klaus J, Weber, Bernhard H F

“…Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been…”
Get full text

Nuclear and mitochondrial genetic variants associated with mitochondrial DNA copy number by Koller, Adriana, Filosi, Michele, Weissensteiner, Hansi, Fazzini, Federica, Gorski, Mathias, Pattaro, Cristian, Schönherr, Sebastian, Forer, Lukas, Herold, Janina M., Stark, Klaus J., Döttelmayer, Patricia, Hicks, Andrew A., Pramstaller, Peter P., Würzner, Reinhard, Eckardt, Kai-Uwe, Heid, Iris M., Fuchsberger, Christian, Lamina, Claudia, Kronenberg, Florian

“…Mitochondrial DNA copy number (mtDNA-CN) is a biomarker for mitochondrial dysfunction associated with several diseases. Previous genome-wide association…”
Get full text

Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation by Winkler, Thomas W, Justice, Anne E, Cupples, L Adrienne, Kronenberg, Florian, Kutalik, Zoltán, Heid, Iris M

“…Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as…”
Get full text

Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration by Grassmann, Felix, Heid, Iris M, Weber, Bernhard H F

“…Age-related macular degeneration (AMD) is the leading cause of blindness in ageing societies, triggered by both environmental and genetic factors. The…”
Get full text

NT-proBNP Predicts Cardiovascular Death in the General Population Independent of Left Ventricular Mass and Function: Insights from a Large Population-Based Study with Long-Term Follow-Up by Dietl, Alexander, Stark, Klaus, Zimmermann, Martina E, Meisinger, Christa, Schunkert, Heribert, Birner, Christoph, Maier, Lars S, Peters, Annette, Heid, Iris M, Luchner, Andreas

“…B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) predict cardiovascular endpoints in patients and all-cause death in the general population…”
Get full text

Changes in healthcare seeking and lifestyle in old aged individuals during COVID-19 lockdown in Germany: the population-based AugUR study by Brandl, Caroline, Zimmermann, Martina E, Günther, Felix, Dietl, Alexander, Küchenhoff, Helmut, Loss, Julika, Stark, Klaus J, Heid, Iris M

“…Containment measures in the COVID-19 pandemic protected individuals at high risk, particularly individuals at old age, but little is known about how these…”
Get full text

Modelling the genetic risk in age-related macular degeneration by Grassmann, Felix, Fritsche, Lars G, Keilhauer, Claudia N, Heid, Iris M, Weber, Bernhard H F

“…Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians…”
Get full text

Long-term pattern of brain natriuretic peptide and N-terminal pro brain natriuretic peptide and its determinants in the general population: contribution of age, gender, and cardiac and extra-cardiac factors by Luchner, Andreas, Behrens, Gundula, Stritzke, Jan, Markus, Marcello, Stark, Klaus, Peters, Annette, Meisinger, Christa, Leitzmann, Michael, Hense, Hans-Werner, Schunkert, Heribert, Heid, Iris M.

“…Aims The natriuretic peptides BNP and NT‐proBNP are potent cardiac markers, but knowledge of long‐term changes is sparse. We thus quantified determinants of…”
Get full text

Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy by Stark, Klaus, Esslinger, Ulrike B, Reinhard, Wibke, Petrov, George, Winkler, Thomas, Komajda, Michel, Isnard, Richard, Charron, Philippe, Villard, Eric, Cambien, François, Tiret, Laurence, Aumont, Marie-Claude, Dubourg, Olivier, Trochu, Jean-Noël, Fauchier, Laurent, Degroote, Pascal, Richter, Anette, Maisch, Bernhard, Wichter, Thomas, Zollbrecht, Christa, Grassl, Martina, Schunkert, Heribert, Linsel-Nitschke, Patrick, Erdmann, Jeanette, Baumert, Jens, Illig, Thomas, Klopp, Norman, Wichmann, H-Erich, Meisinger, Christa, Koenig, Wolfgang, Lichtner, Peter, Meitinger, Thomas, Schillert, Arne, König, Inke R, Hetzer, Roland, Heid, Iris M, Regitz-Zagrosek, Vera, Hengstenberg, Christian

“…Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background. Monogenic forms of DCM are observed in families with mutations…”
Get full text

Population-based study of the durability of humoral immunity after SARS-CoV-2 infection by Peterhoff, David, Wiegrebe, Simon, Einhauser, Sebastian, Patt, Arisha J., Beileke, Stephanie, Günther, Felix, Steininger, Philipp, Niller, Hans H., Burkhardt, Ralph, Küchenhoff, Helmut, Gefeller, Olaf, Überla, Klaus, Heid, Iris M., Wagner, Ralf

“…SARS-CoV-2 antibody quantity and quality are key markers of humoral immunity. However, there is substantial uncertainty about their durability. We investigated…”
Get full text