Vaccination in Pediatric Patients with Sickle-Cell Disease: Uptake Report and Mini-Review

Abstract Background Brazil has one of the highest numbers of births with sickle-cell disease (SCD) in the Americas. Despite the risk of severe illnesses and death due to both vaccine-preventable infections, vaccination uptake in pediatric patients with SCD is unknown. Material and methods Children u...

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Bibliographic Details
Published in:	Journal of tropical pediatrics (1980) Vol. 68; no. 3
Main Authors:	Jarovsky, Daniel, Bastos, Phillipe Romanzini, de Matos, Samantha Faria, Almeida, Flávia Jacqueline, Sáfadi, Marco Aurélio Palazzi, Hegg, Izabella Campos Oliveira, Luporini, Silvia Maria, Berezin, Eitan Naaman
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 05-04-2022
Subjects:	Adolescent Anemia, Sickle Cell - complications Brazil - epidemiology Child Communicable Diseases Humans Infant Vaccination Vaccination Coverage Brazil under-vaccination sickle-cell disease pediatrics invasive disease vaccination
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Summary:	Abstract Background Brazil has one of the highest numbers of births with sickle-cell disease (SCD) in the Americas. Despite the risk of severe illnesses and death due to both vaccine-preventable infections, vaccination uptake in pediatric patients with SCD is unknown. Material and methods Children under 18 years with SCD presenting to routine medical consultations had their vaccination status evaluated according to the national recommendations. Data obtained were classified as ‘Adequate’, ‘Delayed’ or ‘Missing’ vaccination and compared among age groups. Results From 117 children screened, 100 had their vaccination card available. Vaccination coverage of routine vaccines was above 95% for all primary series and both age groups, with varied rates of delays and low missing doses. Among SCD extended vaccination, the most frequently delayed and missed vaccines were those specifically recommended to individuals with SCD as per national guidelines—and particularly those against encapsulated bacteria. Significant and varied rates of missing doses occurred in primary series and booster doses for PPSV23, Hib, menC, hepatitis A and varicella. The average influenza vaccination rate was 69.5%, with higher rates among younger children. Conclusions Children with SCD have alarming under-vaccination rates. Basic prevention strategies in Brazil should be reassessed in this specific population.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0142-6338 1465-3664
DOI:	10.1093/tropej/fmac034