Search Results - "Hegewald, Aldemar"

Quality Assessment of Surgical Disc Samples Discriminates Human Annulus Fibrosus and Nucleus Pulposus on Tissue and Molecular Level by Schubert, Ann-Kathrin, Smink, Jeske J, Arp, Mirko, Ringe, Jochen, Hegewald, Aldemar A, Sittinger, Michael

“…A discrimination of the highly specialised annulus fibrosus (AF) and nucleus pulposus (NP) cells in the mature human intervertebral disc (IVD) is thus far…”
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Annular closure in lumbar microdiscectomy for prevention of reherniation: a randomized clinical trial by Thomé, Claudius, Klassen, Peter Douglas, Bouma, Gerrit Joan, Kuršumović, Adisa, Fandino, Javier, Barth, Martin, Arts, Mark, van den Brink, Wimar, Bostelmann, Richard, Hegewald, Aldemar, Heidecke, Volkmar, Vajkoczy, Peter, Fröhlich, Susanne, Wolfs, Jasper, Assaker, Richard, Van de Kelft, Erik, Köhler, Hans-Peter, Jadik, Senol, Eustacchio, Sandro, Hes, Robert, Martens, Frederic

“…Patients with large annular defects after lumbar discectomy for disc herniation are at high risk of symptomatic recurrence and reoperation. The present study…”
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A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: identification of potential target proteins for gene therapeutic approaches by Mern, Demissew S, Fontana, Johann, Beierfuß, Anja, Thomé, Claudius, Hegewald, Aldemar A

“…Painful degenerative disc diseases have been targeted by different biological treatment approaches. Nucleus pulposus (NP) cells play a central role in…”
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Changes in frailty among patients hospitalized for spine pathologies during the COVID-19 pandemic in Germany—a nationwide observational study by Dengler, Julius, Gheewala, Hussain, Kraft, Clayton N., Hegewald, Aldemar A., Dörre, Ralf, Heese, Oliver, Gerlach, Rüdiger, Rosahl, Steffen, Maier, Bernd, Burger, Ralf, Wutzler, Sebastian, Carl, Barbara, Ryang, Yu-Mi, Hau, Khanh Toan, Stein, Gregor, Gulow, Jens, Allam, Ali, Abduljawwad, Nehad, Rico Gonzalez, Gerardo, Kuhlen, Ralf, Hohenstein, Sven, Bollmann, Andreas, Stoffel, Michael

“…Purpose In spine care, frailty is associated with poor outcomes. The aim of this study was to describe changes in frailty in spine care during the coronavirus…”
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Acute hypoperfusion immediately after subarachnoid hemorrhage: a xenon contrast-enhanced CT study by Schubert, Gerrit Alexander, Seiz, Marcel, Hegewald, Aldemar Andrés, Manville, Jérôme, Thomé, Claudius

“…The acute neurological deficit present immediately after subarachnoid hemorrhage (SAH) correlates with overall outcome. Only limited data are available to…”
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Imbalanced protein expression patterns of anabolic, catabolic, anti-catabolic and inflammatory cytokines in degenerative cervical disc cells: new indications for gene therapeutic treatments of cervical disc diseases by Mern, Demissew S, Beierfuβ, Anja, Fontana, Johann, Thomé, Claudius, Hegewald, Aldemar A

“…Degenerative disc disease (DDD) of the cervical spine is common after middle age and can cause loss of disc height with painful nerve impingement, bone and…”
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The Chemokines CXCL10 and XCL1 Recruit Human Annulus Fibrosus Cells by HEGEWALD, Aldemar A, NEUMANN, Katja, KALWITZ, Gregor, FREYMANN, Undine, ENDRES, Michaela, SCHMIEDER, Kirsten, KAPS, Christian, THOME, Claudius

“…Human annulus fibrosus tissue and cells were analyzed for the presence of chemokine receptors and the migratory effect of selected chemokines. To investigate…”
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Effects of the COVID-19 Pandemic on Spinal Fusion Procedures for Spinal Infections in a Nationwide Hospital Network in Germany by Abduljawwad, Nehad, Pamnani, Sunisha, Stoffel, Michael, Kraft, Clayton N, Hegewald, Aldemar A, Dörre, Ralf, Heese, Oliver, Gerlach, Rüdiger, Rosahl, Steffen, Maier, Bernd, Burger, Ralf, Wutzler, Sebastian, Carl, Barbara, Ryang, Yu-Mi, Hau, Khanh Toan, Stein, Gregor, Gulow, Jens, Kuhlen, Ralf, Hohenstein, Sven, Bollmann, Andreas, Dengler, Julius

“…The full impact of the COVID-19 pandemic on surgical spine care is difficult to assess due to a lack in nationwide evidence from more recent phases of the…”
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Biomechanical investigation of lumbar hybrid stabilization in two-level posterior instrumentation by Hegewald, Aldemar Andres, Hartmann, Sebastian, Keiler, Alexander, Scheufler, Kai Michael, Thomé, Claudius, Schmoelz, Werner

“…Purpose Hybrid stabilization with a dynamic implant has been suggested to avoid adjacent segment disease by creating a smoother transition zone from the…”
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Prevention of implant-associated spinal infections: the GAID-protocol by Przybyl, Joanna Maria, Hegewald, Aldemar Andres

“…The purpose of this study is to investigate the efficacy of the GAID-Protocol, a bundle of intra- and postoperative infection prevention measures, to reduce…”
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Hypoperfusion in the acute phase of subarachnoid hemorrhage by Schubert, Gerrit Alexander, Seiz, Marcel, Hegewald, Aldemar Andrés, Manville, Jérôme, Thomé, Claudius

“…Acute disruption of cerebral perfusion and metabolism is a well-established hallmark of the immediate phase after subarachnoid hemorrhage (SAH). It is thought…”
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Adequacy of herniated disc tissue as a cell source for nucleus pulposus regeneration: Laboratory investigation by HEGEWALD, Aldemar A, ENDRES, Michaela, ABBUSHI, Alexander, CABRAJA, Mario, WOICIECHOWSKY, Christian, SCHMIEDER, Kirsten, KAPS, Christian, THOME, Claudius

“…Object The object of this study was to characterize the regenerative potential of cells isolated from herniated disc tissue obtained during microdiscectomy…”
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Towards biological anulus repair: TGF-β3, FGF-2 and human serum support matrix formation by human anulus fibrosus cells by Hegewald, Aldemar A, Zouhair, Sabra, Endres, Michaela, Cabraja, Mario, Woiciechowsky, Christian, Thomé, Claudius, Kaps, Christian

“…Abstract Closure and biological repair of anulus fibrosus (AF) defects in intervertebral disc diseases is a therapeutic challenge. The aim of our study was to…”
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Comparison of posterior foraminotomy and anterior foraminotomy with fusion for treating spondylotic foraminal stenosis of the cervical spine: study protocol for a randomized controlled trial (ForaC) by Tschugg, Anja, Neururer, Sabrina, Scheufler, Kai Michael, Ulmer, Hanno, Thomé, Claudius, Hegewald, Aldemar Andres

“…Cervical radiculopathy caused by spondylotic foraminal stenosis may require surgical treatment. Surgical options include anterior cervical foraminotomy and…”
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Regeneration of Intervertebral Disc Tissue by Resorbable Cell-Free Polyglycolic Acid-Based Implants in a Rabbit Model of Disc Degeneration by ABBUSHI, Alexander, ENDRES, Michaela, KAPS, Christian, WOICIECHOWSKY, Christian, CABRAJA, Mario, KROPPENSTEDT, Stefan Nicolas, THOMALE, Ulrich Wilhelm, SITTINGER, Michael, HEGEWALD, Aldemar Andres, MORAWIETZ, Lars, LEMKE, Arne-Jorn, BANSEMER, Victor-Gotz

“…: Different biologic strategies exist to treat degenerative disc disease. Tissue engineering approaches favor autologous chondrocyte transplantation. In our…”
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Biomechanical testing of a polymer-based biomaterial for the restoration of spinal stability after nucleotomy by Hegewald, Aldemar A, Knecht, Sven, Baumgartner, Daniel, Gerber, Hans, Endres, Michaela, Kaps, Christian, Stüssi, Edgar, Thomé, Claudius

“…Surgery for disc herniations can be complicated by two major problems: painful degeneration of the spinal segment and re-herniation. Therefore, we examined an…”
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Effects of initial boost with TGF-beta 1 and grade of intervertebral disc degeneration on 3D culture of human annulus fibrosus cells by Hegewald, Aldemar Andres, Cluzel, Jessie, Krüger, Jan Philipp, Endres, Michaela, Kaps, Christian, Thomé, Claudius

“…Three-dimensional (3D) culture in porous biomaterials as well as stimulation with growth factors are known to be supportive for intervertebral disc cell…”
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A 3D environment for anulus fibrosus regeneration: Laboratory investigation by CABRAJA, Mario, ENDRES, Michaela, HEGEWALD, Aldemar A, VETTERLEIN, Samuel, THOMT, Claudius, WOICIECHOWSKY, Christian, KAPS, Christian

“…Object Biological repair strategies for the treatment of degenerated intervertebral discs are of growing interest. In addition to the development of nucleus…”
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Regenerative and immunogenic characteristics of cultured nucleus pulposus cells from human cervical intervertebral discs by Stich, Stefan, Stolk, Meaghan, Girod, Pierre Pascal, Thomé, Claudius, Sittinger, Michael, Ringe, Jochen, Seifert, Martina, Hegewald, Aldemar Andres

“…Cell-based regenerative approaches have been suggested as primary or adjuvant procedures for the treatment of degenerated intervertebral disc (IVD) diseases…”
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Enhancing human nucleus pulposus cells for biological treatment approaches of degenerative intervertebral disc diseases: a systematic review by Mern, Demissew Shenegelegn, Beierfuß, Anja, Thomé, Claudius, Hegewald, Aldemar Andres

“…Intervertebral disc (IVD) degeneration has been described as an aberrant, cell‐mediated, age‐ and genetics‐dependent molecular degeneration process, which can…”
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