Search Results - "Hegeman, Ingrid M."

Hypocretin (orexin) loss in Parkinson's disease by Fronczek, Rolf, Overeem, Sebastiaan, Lee, Sandy Y. Y., Hegeman, Ingrid. M., van Pelt, Johannes, van Duinen, Sjoerd. G., Lammers, Gert Jan, Swaab, Dick F.

“…The hypothalamic hypocretin (orexin) system plays a central role in the regulation of various functions, including sleep/wake regulation and metabolism. There…”
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SOX Antibodies in Small-Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome: Frequency and Relation With Survival by TITULAER, Maarten J, KLOOSTER, Rinse, VAN DER MAAREL, Silvère M, VERSCHUUREN, Jan J. G. M, POTMAN, Marko, SABATER, Lidia, GRAUS, Francesc, HEGEMAN, Ingrid M, THIJSSEN, Peter E, WIRTZ, Paul W, TWIJNSTRA, Albert, SILLEVIS SMITT, Peter A. E

“…SOX1 antibodies are common in small-cell lung carcinoma (SCLC) with and without paraneoplastic syndrome (PNS) and can serve as serological tumor marker…”
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Hypocretin (orexin) loss and sleep disturbances in Parkinson's Disease by Fronczek, Rolf, Overeem, Sebastiaan, Lee, Sandy Y.Y., Hegeman, Ingrid. M., van Pelt, Johannes, van Duinen, Sjoerd G., Lammers, Gert Jan, Swaab, Dick F.

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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Family Members With a Pathogenic NOTCH3 Variant Can Have a Normal Brain Magnetic Resonance Imaging and Skin Biopsy Beyond Age 50 Years by Hack, Remco J., Gravesteijn, Gido, Cerfontaine, Minne N., Hegeman, Ingrid M., Mulder, Aat A., Lesnik Oberstein, Saskia A.J., Rutten, Julie W.

“…To determine whether extremely mild small vessel disease (SVD) phenotypes can occur in variant carriers from Cerebral Autosomal Dominant Arteriopathy with…”
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NOTCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature by Gravesteijn, Gido, Hack, Remco J., Mulder, Aat A., Cerfontaine, Minne N., Doorn, Remco, Hegeman, Ingrid M., Jost, Carolina R., Rutten, Julie W., Lesnik Oberstein, Saskia A. J.

“…Aims CADASIL, the most prevalent hereditary cerebral small vessel disease, is caused by cysteine‐altering NOTCH3 variants (NOTCH3cys) leading to vascular…”
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NOTCH3 VARIANT POSITION IS ASSOCIATED WITH VASCULAR NOTCH3 AGGREGATION LOAD IN CADASIL PATIENTS by Gravesteijn, Gido, Hack, Remco J., Mulder, Aat A., Cerfontaine, Minne N., van Doorn, Remco, Hegeman, Ingrid M., Jost, Carolina R., Rutten, Julie W., Oberstein, Saskia A.J. Lesnik

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Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy by Overeem, Sebastiaan, Verschuuren, Jan J., Fronczek, Rolf, Schreurs, Liesbeth, den Hertog, Heleen, Hegeman-Kleinn, Ingrid M., van Duinen, Sjoerd G., Unmehopa, Unga A., Swaab, Dick F., Lammers, Gert Jan

“…Most human patients with narcolepsy have no detectable hypocretin-1 in their cerebrospinal fluid. The cause of this hypocretin deficiency is unknown, but the…”
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The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation by Rutten, Julie W, Klever, Roselin R, Hegeman, Ingrid M, Poole, Dana S, Dauwerse, Hans G, Broos, Ludo A M, Breukel, Cor, Aartsma-Rus, Annemieke M, Verbeek, J Sjef, van der Weerd, Louise, van Duinen, Sjoerd G, van den Maagdenberg, Arn M J M, Lesnik Oberstein, Saskia A J

“…CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations…”
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Immunohistochemical screening for antibodies in recent onset type 1 narcolepsy and after H1N1 vaccination by van der Heide, Astrid, Hegeman-Kleinn, Ingrid M, Peeters, Els, Lammers, Gert J, Fronczek, Rolf

“…Abstract Narcolepsy type 1 patients typically have undetectable hypocretin-1 levels in the cerebrospinal fluid (CSF), as a result of a selective loss of the…”
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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Family Members With a Pathogenic NOTCH3 Variant Can Have a Normal Brain Magnetic Resonance Imaging and Skin Biopsy Beyond Age 50 Years by Hack, Remco J., Gravesteijn, Gido, Cerfontaine, Minne N., Hegeman, Ingrid M., Mulder, Aat A., Lesnik Oberstein, Saskia A.J., Rutten, Julie W.

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NO TCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature by Gravesteijn, Gido, Hack, Remco J., Mulder, Aat A., Cerfontaine, Minne N., van Doorn, Remco, Hegeman, Ingrid M., Jost, Carolina R., Rutten, Julie W., Lesnik Oberstein, Saskia A. J.

“…The position of the pathogenic NOTCH3 variant in CADASIL patients is correlated with mutant NOTCH3 protein aggregation levels within the vessel wall in skin…”
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Evaluation of diagnostic NOTCH3 immunostaining in CADASIL by OBERSTEIN, Saskia A. J. Lesnik, VAN DUINEN, Sjoerd G, VAN DEN BOOM, Rivka, MAAT-SCHIEMAN, Marion L. C, VAN BUCHEM, Mark A, VAN HOUWELINGEN, Hans C, HEGEMAN-KLEINN, Ingrid M, FERRARI, Michel D, BREUNING, Martijn H, HAAN, Joost

“…CADASIL is caused by mutations in the NOTCH3 gene. Although increasingly recognized as a disease entity, the diagnostic confirmation can be lengthy or…”
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Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type by Maat-Schieman, Marion L C, Yamaguchi, Haruyasu, Hegeman-Kleinn, Ingrid M, Welling-Graafland, Corrie, Natté, Remco, Roos, Raymund A C, van Duinen, Sjoerd G

“…Although the amyloid beta protein (Abeta) E693Q mutation enhances Abeta fibrillization in vitro and cerebral amyloid angiopathy (CAA) in vivo, brain…”
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Glial reactions and the clearance of amyloid [beta] protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type by Maat-Schieman, Marion L C, Yamaguchi, Haruyasu, Hegeman-Kleinn, Ingrid M, Welling-Graafland, Corrie, Natté, Remco, Roos, Raymund A C, van Duinen, Sjoerd G

“…Although the amyloid [beta] protein (A[beta]) E693Q mutation enhances A[beta] fibrillization in vitro and cerebral amyloid angiopathy (CAA) in vivo, brain…”
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