Search Results - "Hegelund, Anne Charlotte"

Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation by Bjerre Knudsen, Lotte, Madsen, Lars Wichmann, Andersen, Søren, Almholt, Kasper, de Boer, Anne S, Drucker, Daniel J, Gotfredsen, Carsten, Egerod, Frederikke Lihme, Hegelund, Anne Charlotte, Jacobsen, Helene, Jacobsen, Søren Dyring, Moses, Alan C, Mølck, Anne-Marie, Nielsen, Henriette S, Nowak, Jette, Solberg, Helene, Thi, Tu D. L, Zdravkovic, Milan

“…Liraglutide is a glucagon-like peptide-1 (GLP-1) analog developed for type 2 diabetes. Long-term liraglutide exposure in rodents was associated with thyroid…”
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Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues by Glendorf, Tine, Knudsen, Louise, Stidsen, Carsten E, Hansen, Bo F, Hegelund, Anne Charlotte, Sørensen, Anders R, Nishimura, Erica, Kjeldsen, Thomas

“…Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to…”
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Comparison of intracellular signalling by insulin and the hypermitogenic AspB10 analogue in MCF-7 breast adenocarcinoma cells by Oleksiewicz, Martin B., Bonnesen, Christine, Hegelund, Anne Charlotte, Lundby, Anders, Holm, Gitte-Mai Nelander, Jensen, Marianne B., Krabbe, Jonas S.

“…We compared mitogenicity and intracellular signalling by human insulin and the AspB10 (X‐10) human insulin analogue in MCF‐7 human mammary adenocarcinoma…”
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Administration of recombinant FVIIa (rFVIIa) to concizumab‐dosed monkeys is safe, and concizumab does not affect the potency of rFVIIa in hemophilic rabbits by Lauritzen, Brian, Olling, Janne, Abel, Kristin L., Augustsson, Cecilia, Balling, Kristoffer, Bjelke, Mads, Hegelund, Anne Charlotte, Hilden, Ida

“…Essentials Hemophilia patients on concizumab prophylaxis may need rFVIIa to treat breakthrough bleeds. Effect and safety of concizumab + rFVIIa were tested…”
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A weighted method for estimation of receptor occupancy for pharmacodynamic measurements in drug development by Sternebring, Ola, Alifrangis, Lene, Christensen, Toke Folke, Ji, Hong, Hegelund, Anne Charlotte, Högerkorp, Carl-Magnus

“…Background Flow cytometry‐based receptor occupancy (RO) assessments for pharmacodynamic (PD) response measurements along with drug pharmacokinetic (PK)…”
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Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues by Lundby, Anders, Bolvig, Pernille, Hegelund, Anne Charlotte, Hansen, Bo F., Worm, Jesper, Lützen, Anne, Billestrup, Nils, Bonnesen, Christine, Oleksiewicz, Martin B.

“…There is a medical need for new insulin analogues. Yet, molecular alterations to the insulin molecule can theoretically result in analogues with carcinogenic…”
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Validation of a flow cytometry-based assay to assess C5aR receptor occupancy on neutrophils and monocytes for use in drug development by Quadrini, Karen J., Hegelund, Anne Charlotte, Cortes, Kasia E., Xue, Chengsen, Kennelly, Susan M., Ji, Hong, Högerkorp, Carl-Magnus, Mc Closkey, Thomas W.

“…The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is…”
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Synchronization in G₀/G₁ enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin by Bonnesen, Christine, Nelander, Gitte-Mai, Hansen, Bo Falck, Jensen, Pia, Krabbe, Jonas S, Jensen, Marianne B, Hegelund, Anne Charlotte, Svendsen, Jette E, Oleksiewicz, Martin B

“…Evaluating mitogenic signaling specifically through the human insulin receptor (IR) is relevant for the preclinical safety assessment of developmental insulin…”
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Glucagon-Like Peptide-1 Receptor Agonists Activate Rodent Thyroid C-Cells Causing Calcitonin Release and C-Cell Proliferation by Knudsen, Lotte Bjerre, Madsen, Lars Wichmann, Andersen, Søren, Almholt, Kasper, de Boer, Anne S, Drucker, Daniel J, Gotfredsen, Carsten, Egerod, Frederikke Lihme, Hegelund, Anne Charlotte, Jacobsen, Helene, Jacobsen, Søren Dyring, Moses, Alan C, Mølck, Anne Marie, Nielsen, Henriette S, Nowak, Jette, Solberg, Helene, Thi, Tu D. L, Zdravkovic, Milan

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Synchronization in G sub(0)/G sub(1) enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin by Bonnesen, Christine, Nelander, Gitte-Mai, Hansen, Bo Falck, Jensen, Pia, Krabbe, Jonas S, Jensen, Marianne B, Hegelund, Anne Charlotte, Svendsen, Jette E, Oleksiewicz, Martin B

“…Evaluating mitogenic signaling specifically through the human insulin receptor (IR) is relevant for the preclinical safety assessment of developmental insulin…”
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Generalized Cellular Hypertrophy is Induced by a Dual-Acting PPAR Agonist in Rat Urinary Bladder Urothelium In Vivo by Oleksiewicz, Martin B., Thorup, Inger, Nielsen, Henriette S., Andersen, Hanne V., Hegelund, Anne Charlotte, Iversen, Lars, Guldberg, Torben S., Brinck, Peter R., Sjogren, Ingrid, Thinggaard, Ulla K., Jørgensen, Lis, Jensen, Marianne B.

“…Some developmental dual-acting PPARα/γ agonists, such as ragaglitazar, have shown carcinogenic effects in the rodent urinary bladder urothelium after…”
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