Search Results - "Hegde, Shweta M."

IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses by Carrero, Rosa M. Santana, Beceren-Braun, Figen, Rivas, Sarai C., Hegde, Shweta M., Gangadharan, Achintyan, Plote, Devin, Pham, Gabriel, Anthony, Scott M., Schluns, Kimberly S.

“…Previous studies have provided evidence that IL-15 expression within human tumors is crucial for optimal antitumor responses; however, the regulation of IL-15…”
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NKTR-255 is a polymer-conjugated IL-15 with unique mechanisms of action on T and natural killer cells by Robinson, Tanya O, Hegde, Shweta M, Chang, Allison, Gangadharan, Achintyan, Rivas, Sarai, Madakamutil, Loui, Zalevsky, Jonathan, Miyazaki, Takahiro, Schluns, Kimberly S

“…NKTR-255 is a PEG conjugate of recombinant human IL-15 (rhIL-15) being examined as a potential cancer immunotherapeutic. Since IL-15 responses can be mediated…”
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IL-15 deficient colon carcinomas have decreased cytolytic lymphocytes and skewed myeloid cell populations by Schluns, Kimberly S, Chou, Chih-Chien, Carrero, Rosa M Santana, Davis, Richard Eric, Hegde, Shweta M

“…Abstract Loss of IL-15 expression by colon tumors strongly correlates with classification as microsatellite stable, decreased tumor infiltrating lymphocytes…”
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