Search Results - "Hegde, Bindu"

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway by Singh, Rajbir, Chandrashekharappa, Sandeep, Bodduluri, Sobha R., Baby, Becca V., Hegde, Bindu, Kotla, Niranjan G., Hiwale, Ankita A., Saiyed, Taslimarif, Patel, Paresh, Vijay-Kumar, Matam, Langille, Morgan G. I., Douglas, Gavin M., Cheng, Xi, Rouchka, Eric C., Waigel, Sabine J., Dryden, Gerald W., Alatassi, Houda, Zhang, Huang-Ge, Haribabu, Bodduluri, Vemula, Praveen K., Jala, Venkatakrishna R.

“…The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of…”
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Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy by Chuntova, Pavlina, Downey, Kira M, Hegde, Bindu, Almeida, Neil D, Okada, Hideho

“…Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with…”
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Inflammasome-Independent Leukotriene B4 Production Drives Crystalline Silica–Induced Sterile Inflammation by Hegde, Bindu, Bodduluri, Sobha R., Satpathy, Shuchismita R., Alghsham, Ruqaih S., Jala, Venkatakrishna R., Uriarte, Silvia M., Chung, Dong-Hoon, Lawrenz, Matthew B., Haribabu, Bodduluri

“…Abstract Silicosis is a lung inflammatory disease caused by chronic exposure to crystalline silica (CS). Leukotriene B4 (LTB4) plays an important role in…”
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Zinc Oxide Nanowires Exposure Induces a Distinct Inflammatory Response via CCL11-Mediated Eosinophil Recruitment by Alghsham, Ruqaih S, Satpathy, Shuchismita R, Bodduluri, Sobha R, Hegde, Bindu, Jala, Venkatakrishna R, Twal, Waleed, Burlison, Joseph A, Sunkara, Mahendra, Haribabu, Bodduluri

“…High aspect ratio zinc oxide nanowires (ZnONWs) have become one of the most important products in nanotechnology. The wide range applications of ZnONWs have…”
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Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Immisch et al by Chheda, Zinal S, Mueller, Sabine, Hegde, Bindu, Yamamichi, Akane, Butterfield, Lisa H, Okada, Hideho

“…While their liquid chromatography-tandem mass spectrometry (LC-MS/MS) failed to detect endogenously processed mutant H3.3-derived peptides in U87MG cells…”
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IMMU-28. INDUCTION OF TERTIARY LYMPHOID STRUCTURE-LIKE T-CELL CLUSTERS BY DELIVERY OF A NOVEL GENE COMBINATION INTO AN IMMUNOCOMPETENT MOUSE MODEL OF GLIOBLASTOMA by Downey, Kira, Hegde, Bindu, Chheda, Zinal, Zhang, Jason, Okada, Hideho

“…Abstract The lack of conventional lymphatic drainage to and from the brain parenchyma restricts the capacity of the peripheral immune system to recognize and…”
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RASA2 ablation in T cells boosts antigen sensitivity and long-term function by Carnevale, Julia, Shifrut, Eric, Kale, Nupura, Nyberg, William A., Blaeschke, Franziska, Chen, Yan Yi, Li, Zhongmei, Bapat, Sagar P., Diolaiti, Morgan E., O’Leary, Patrick, Vedova, Shane, Belk, Julia, Daniel, Bence, Roth, Theodore L., Bachl, Stefanie, Anido, Alejandro Allo, Prinzing, Brooke, Ibañez-Vega, Jorge, Lange, Shannon, Haydar, Dalia, Luetke-Eversloh, Marie, Born-Bony, Maelys, Hegde, Bindu, Kogan, Scott, Feuchtinger, Tobias, Okada, Hideho, Satpathy, Ansuman T., Shannon, Kevin, Gottschalk, Stephen, Eyquem, Justin, Krenciute, Giedre, Ashworth, Alan, Marson, Alexander

“…The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive signals from both extrinsic factors and intrinsic inhibitory…”
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Abstract 74: Engineering tertiary lymphoid structures for glioblastoma: A novel gene combination promotes therapeutic TLS formation in an immune-competent mouse model of GBM by Downey, Kira Morgan, Hegde, Bindu, Chheda, Zinal, Zhang, Jason, Okada, Hideho

“…Abstract The absence of conventional lymphatic access to the brain parenchyma restricts the capacity of the peripheral immune system to recognize and elicit…”
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Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth by Satpathy, Shuchismita R., Jala, Venkatakrishna R., Bodduluri, Sobha R., Krishnan, Elangovan, Hegde, Bindu, Hoyle, Gary W., Fraig, Mostafa, Luster, Andrew D., Haribabu, Bodduluri

“…Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study,…”
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IMMU-38. CRISPR BASED GENOME EDITING OF HUMAN T CELLS TO TARGET H3.3K27M MUTATION IN GLIOMAS by Hegde, Bindu, Roth, Theodore, Nguyen, David, Chheda, Zinal, Apathy, Ryan, Marson, Alex, Okada, Hideho

“…Abstract We recently identified an HLA-A*02:01-restricted CD8 T cell epitope encompassing the H3.3K27M mutation, which is common in diffuse midline glioma, and…”
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Inflammasome Independent Leukotriene B4 Production Drives Crystalline Silica Induced Sterile Inflammation in Lungs by Hegde, Bindu, Satpathy, Shuchismita, Bodduluri, Sobha Rani, Jala, Venkatakrishna R, Bodduluri, Haribabu

“…Abstract Occupational exposure to Crystalline Silica (CS) is a major public health concern with millions of workers continuously exposed to CS. Deposition of…”
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Inflammasome-Independent Leukotriene B 4 Production Drives Crystalline Silica-Induced Sterile Inflammation by Hegde, Bindu, Bodduluri, Sobha R, Satpathy, Shuchismita R, Alghsham, Ruqaih S, Jala, Venkatakrishna R, Uriarte, Silvia M, Chung, Dong-Hoon, Lawrenz, Matthew B, Haribabu, Bodduluri

“…Silicosis is a lung inflammatory disease caused by chronic exposure to crystalline silica (CS). Leukotriene B (LTB ) plays an important role in neutrophilic…”
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Considerations when treating high-grade pediatric glioma patients with immunotherapy by Crotty, Erin, Downey, Kira, Ferrerosa, Lauren, Flores, Catherine, Hegde, Bindu, Raskin, Scott, Hwang, Eugene, Vitanza, Nicholas, Okada, Hideho

“…Children with high-grade gliomas (pHGGs) represent a clinical population in substantial need of new therapeutic options given the inefficacy and toxicity of…”
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Targeted delivery of microbial metabolite, urolithin A protects from chemically (DSS or TNBS) induced colitis in pre-clinical models by Singh, Rajbir, Hegde, Bindu, Von Baby, Becca, Sadeep, C, Kotla, Niranjan, Chandrasekar, Bhargavi, Marepally, Srujan, Bodduluri, Haribabu, Vemula, Praveen K, Jala, Venkatakrishna R

“…Abstract Epidemiological data suggests that consumption of diets rich in phytochemicals are protective in inflammatory bowel diseases (IBDs). However, the…”
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Enhancement of gut barrier function by microbial metabolite, urolithin A via AhR-Nrf2 dependent pathways in IBD by Jala, Venkatakrishna R, Singh, Rajbir, Chandrashekarappa, Sandeep, Bodduluri, Sobha Rani, Becca, Baby V, Hegde, Bindu, Kotla, Niranjan, Hiwale, Ankita A, Saiyed, Taslimarif, Patel, Paresh, Vijay-Kumar, Matam, Langille, Morgan, Douglas, Gavin M, Dryden, Gerald, Cheng, Xi, Rouchka, Eric, Waigel, Sabine J, Alatassi, Houda, Zhang, Huang-Ge, Haribabu, Bodduluri, Vemula, Praveen K

“…Abstract Inflammatory bowel diseases (IBD) consisting of Crohn’s and ulcerative colitis are resultant of dysregulation of the immune system leading to…”
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Abstract 578: A functional approach to identifying and engineering TCRs results in highly-potent and specific TCRs for TCR-T cell therapy by Leonard, John D., Ramirez, Alejandro, Romero, Jason, Kleiner, Jake, Dreux, Joanna, Hegde, Bindu, Xie, Bryan, Sharathchandra, Akshay, Katz, Nathan, DeAlmeida, Venita I., Gerber, Hans-Peter, Gee, Marvin H., Sibener, Leah V.

“…Abstract Peptide-HLA (pHLA)- targeting therapeutics, such as T cell receptor-engineered T cells (TCR-T), have had clinical success in treating solid tumors…”
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A semi-synthetic natural product blocks collagen induced arthritis by preferentially suppressing the production of IL-6 by Kulkarni-Almeida, Asha, Shah, Meet, Jadhav, Mahesh, Hegde, Bindu, Trivedi, Jacqueline, Mishra, Prabhu D., Mahajan, Girish B., Dadarkar, Shruta, Gupte, Ravindra, Dagia, Nilesh

“…Rheumatoid arthritis (RA), an autoimmune-inflammatory disease is characterized by dysregulation of signal transduction pathways, increased production of…”
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Vitamin E is a MIF Inhibitor by Hegde, Bindu, Vadnal, Prashant, Sanghavi, Jingal, Korde, Vaidehi, Kulkarni-Almeida, Asha A., Dagia, Nilesh M.

“…► In this study, we investigated the hypothesis that Vitamin E possesses MIF inhibitory activity. ► Vitamin E inhibits enzymatic activity of MIF. ► Vitamin E…”
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NF-κB dependent anti-inflammatory activity of chlorojanerin isolated from Saussurea heteromalla by Saklani, Arvind, Hegde, Bindu, Mishra, Prabha, Singh, Ruchi, Mendon, Monica, Chakrabarty, Debarshi, Kamath, Divya V., Lobo, Aurelio, Mishra, Prabhu Dutt, Dagia, Nilesh M., Padigaru, Muralidhara, Kulkarni-Almeida, Asha A.

“…Medicinal plants have shown great promise as a source of novel drug compounds for the treatment of inflammatory disorders. In our search for new entities with…”
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Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth by Satpathy, Shuchismita R., Jala, Venkatakrishna R., Bodduluri, Sobha R., Krishnan, Elangovan, Hegde, Bindu, Hoyle, Gary, Fraig, Mostafa, Luster, Andrew D., Haribabu, Bodduluri

“…Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study,…”
Get full text