Search Results - "Hegde, Ashok N"

Recent Developments in Transcriptional and Translational Regulation Underlying Long-Term Synaptic Plasticity and Memory by Hegde, Ashok N, Smith, Spencer G

“…Formation of long-term synaptic plasticity that underlies long-term memory requires new protein synthesis. Years of research has elucidated some of the…”
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Perturbations of Ubiquitin-Proteasome-Mediated Proteolysis in Aging and Alzheimer's Disease by Hegde, Ashok N, Smith, Spencer G, Duke, Lindsey M, Pourquoi, Allison, Vaz, Savannah

“…The ubiquitin-proteasome pathway (UPP) has multiple roles in the normal nervous system, including the development of synaptic connections and synaptic…”
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Degradation of Transcriptional Repressor ATF4 during Long-Term Synaptic Plasticity by Smith, Spencer G, Haynes, Kathryn A, Hegde, Ashok N

“…Maintenance of long-term synaptic plasticity requires gene expression mediated by cAMP-responsive element binding protein (CREB). Gene expression driven by…”
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Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity by Dong, Chenghai, Bach, Svitlana V, Haynes, Kathryn A, Hegde, Ashok N

“…Proteolysis by the ubiquitin-proteasome pathway appears to have a complex role in synaptic plasticity, but its various functions remain to be elucidated. Using…”
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Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease by Hegde, Ashok N., Upadhya, Sudarshan C.

“…Proteolysis by the ubiquitin–proteasome pathway (UPP) is now widely recognized as a molecular mechanism controlling myriad normal functions in the nervous…”
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Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity by Hegde, Ashok N

“…A proteolytic pathway in which attachment of a small protein, ubiquitin, marks the substrates for degradation by a multi-subunit complex called the proteasome…”
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Proteasome Inhibition Enhances the Induction and Impairs the Maintenance of Late-Phase Long-Term Potentiation by Dong, Chenghai, Upadhya, Sudarshan C, Ding, Lan, Smith, Thuy K, Hegde, Ashok N

“…Protein degradation by the ubiquitin-proteasome pathway plays important roles in synaptic plasticity, but the molecular mechanisms by which proteolysis…”
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The proteasome and epigenetics: zooming in on histone modifications by Bach Svitlana V., Hegde Ashok N.

“…The proteasome is a structural complex of many proteins that degrades substrates marked by covalent linkage to ubiquitin. Many years of research has shown a…”
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The ubiquitin–proteasome pathway in health and disease of the nervous system by Hegde, Ashok N, Upadhya, Sudarshan C

“…In recent years, proteolysis by the ubiquitin–proteasome pathway has attained prominence as a new molecular mechanism that regulates many vital functions of…”
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Proteolysis, synaptic plasticity and memory by Hegde, Ashok N

“…Protein degradation has many critical functions in the nervous system such as refinement of synaptic connections during development and synaptic plasticity and…”
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The Ubiquitin-Proteasome Pathway and Synaptic Plasticity by Hegde, Ashok N

“…Proteolysis by the ubiquitin-proteasome pathway (UPP) has emerged as a new molecular mechanism that controls wide-ranging functions in the nervous system,…”
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Editorial: Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System by Hegde, Ashok N, van Leeuwen, Fred W

“…Editorial on the Research Topic Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System Proteolysis by the ubiquitin-proteasome…”
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Role of the ubiquitin proteasome system in Alzheimer's disease by Upadhya, Sudarshan C, Hegde, Ashok N

“…Though Alzheimer's disease (AD) is a syndrome with well-defined clinical and neuropathological manifestations, an array of molecular defects underlies its…”
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Ubiquitin‐proteasome‐mediated CREB repressor degradation during induction of long‐term facilitation by Upadhya, Sudarshan C., Smith, Thuy K., Hegde, Ashok N.

“…Long‐term facilitation in Aplysia and other forms of long‐term memory in invertebrates and vertebrates require the gene expression cascade induced by…”
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Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain by Ding, Lan, Mychaleckyj, Josyf C., Hegde, Ashok N.

“…RGS4 (regulator of G protein signaling 4) protein is a GTPase-activating protein specific for Gi/o and Gq α subunits. It is highly expressed in brain but the…”
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Mechanisms for Generating the Autonomous cAMP-Dependent Protein Kinase Required for Long-Term Facilitation in Aplysia by Chain, Daniel G, Casadio, Andrea, Schacher, Samuel, Hegde, Ashok N, Valbrun, Mireille, Yamamoto, Naoki, Goldberg, Alfred L, Bartsch, Dusan, Kandel, Eric R, Schwartz, James H

“…The formation of a persistently active cAMP-dependent protein kinase (PKA) is critical for establishing long-term synaptic facilitation (LTF) in Aplysia. The…”
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Proteasome regulates the mediators of cytoplasmic polyadenylation signaling during late-phase long-term potentiation by Dong, Chenghai, Vashisht, Anirudh, Hegde, Ashok N.

“…•We tested the link between the proteasome and translation during L-LTP.•We examined components of cytoplasmic polyadenylation signaling.•A polyadenylation…”
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Age-dependent changes in brain hydration and synaptic plasticity by Vashisht, Anirudh, Morykwas, Michael, Hegde, Ashok N., Argenta, Louis, McGee, Maria P.

“…•The mouse brain dehydrates during middle age by approximately 10%.•Ex-vivo, hippocampal neuronal function changes in proportion to tissue…”
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Expression of RGS4 Splice Variants in Dorsolateral Prefrontal Cortex of Schizophrenic and Bipolar Disorder Patients by Ding, Lan, Hegde, Ashok N

“…Background Previous molecular and genetic studies have implicated RGS4 (regulator of G protein signaling 4) in schizophrenia (SCZ) and bipolar disorder (BPD),…”
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MHC molecules in the vomeronasal organ: contributors to pheromonal discrimination? by Hegde, Ashok N.

“…The vomeronasal organ of the accessory olfactory system detects pheromones in several vertebrate species. Recent studies of vomeronasal sensory neurons have…”
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