Search Results - "Hegazy, Gehan"

Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities by Bashmail, Hanan A., Alamoudi, Aliaa A., Noorwali, Abdulwahab, Hegazy, Gehan A., AJabnoor, Ghada, Choudhry, Hani, Al-Abd, Ahmed M.

“…The use of anti-cancer adjuvant therapy is rationalized by potentiating the efficacy, and/or protecting from major side effects of chemotherapeutics…”
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Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism by Bashmail, Hanan A, Alamoudi, Aliaa A, Noorwali, Abdulwahab, Hegazy, Gehan A, Ajabnoor, Ghada M, Al-Abd, Ahmed M

“…Thymoquinone (TQ) has shown substantial evidence for its anticancer effects. Using human breast cancer cells, we evaluated the chemomodulatory effect of TQ on…”
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Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications by Hegazy, Gehan A, Awan, Zuhier, Hashem, Enayat, Al-Ama, Nabil, Abunaji, Asmaa Basha

“…Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed…”
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Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents by Arafa, Reem K., Hegazy, Gehan H., Piazza, Gary A., Abadi, Ashraf H.

“…Several derivatives with a quinoline scaffold and a flexible, semi-flexible or rigid side chains at position 8 of the quinoline ring were synthesized and…”
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Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids by Hegazy, Gehan H., Ali, Hamed I.

“…The ibuprofenic acid and mefenamic acid esters coupled with [4-(4-substituted benzylidene amino)phenols] Schiff’s bases revealed remarkable analgesic…”
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Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats: Biochemical and immunohistochemical study by Mustafa, Hesham N, El Awdan, Sally A, Hegazy, Gehan A, Abdel Jaleel, Gehad A

“…The study aims to evaluate the protective effects of coenzyme Q10 (CoQ10) and Cynara scolymus L (CS) on doxorubicin (dox)-induced toxicity. Sixty male rats…”
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Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. A case-control study by Ali, Ehdaa Y, Hegazy, Gehan A, Hashem, Enayat M

“…To evaluate adipokine serum values of irisin, retinol-binding protein 4, and leptin in Saudi cases with type 2 diabetes mellitus (T2DM) for providing markers…”
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Keratometric Outcomes after Simultaneous versus Sequential Intracorneal Ring Segment Implantation with Femtosecond Laser and Corneal Collagen Crosslinking in Egyptian Patients with Keratoconus and Ectasia by Nasrat, Moataz Mohamed, Abdelsalam, Ahmed Medhat, Goily, Mohamed Bassam, Eldib, Amr A, Hegazy, Gehan A

“…Keratoconus (KC) is degenerative corneal disorder, with central and paracentral thinning and corneal ectasia. For KC progressive cases, primary treatment…”
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Protective role of antioxidants on thioacetamide-induced acute hepatic encephalopathy: Biochemical and Ultrastructural study by Mustafa, H.N, El Awdan, Sally A, Hegazy, Gehan A

“…Abstract Thioacetamide (TAA) has been used in development of animal models of acute hepatic encephalopathy (AHE). This experimental study was designed to…”
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Protective role of CoQ10 or L-carnitine on the integrity of the myocardium in doxorubicin induced toxicity by Mustafa, Hesham N, Hegazy, Gehan A, Awdan, Sally A. El, AbdelBaset, Marawan

“…Graphical abstract…”
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Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells by Algehani, Rinad A., Abou Khouzam, Raefa, Hegazy, Gehan A., Alamoudi, Aliaa A., El-Halawany, Ali M., El Dine, Riham S., Ajabnoor, Ghada A., Al-Abbasi, Fahad A., Baghdadi, Mohammed A., Elsayed, Ibrahim, Hattori, Masao, Al-Abd, Ahmed M.

“…Several terpenoids were isolated from Ganoderma colossum with potential chemotherapeutic properties against different solid tumor cells. Herein, we further…”
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Diet influences levels of plasma lipopolysaccharide (LPS) and its soluble receptor (sCD14) in Saudis by Bahijri, Suhad Maatoug, Ajabnoor, Ghada Mohammad, Hegazy, Gehan Abdel-Fattah, Borai, Anwar Abdullah, Eldakhakhny, Basmah Medhat, Alsheikh, Lubna Nihad, Harakeh, Steve Mustapha

“…This study aimed to investigate the association between serum levels of LPS, sCD14 and hs-CRP, and markers of obesity, and dietary composition of healthy…”
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New ibuprofen derivatives as H2S and NO donors as safer anti-inflammatory agents by Hassan, Ghaneya S, Hegazy, Gehan H, Ibrahim, Noha M, Fahim, Samar H

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Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone by Al-Salem, Huda S.A., Hegazy, Gehan H., El-Taher, Kamal E.H., El-Messery, Shahenda M., Al-Obaid, Abdulrahman M., El-Subbagh, Hussein I.

“…Structures of compounds 47, 63, 68 and 73, the most active anticonvulsants with a remarkable 100% protection against PTZ induced convulsions. [Display omitted]…”
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Expression Levels of lncRNA NEAT1, miRNA-21, and IL-17 in a Group of Egyptian Patients with Behçet’s Disease: Relation to Disease Manifestations and Activity by Hussein, Wafaa, Ramadan, Hala, Labib, Safa, Hegazy, Gehan, Shaker, Olfat, Yusuf, Sherif, Hassanien, Mohammed, Haroon, Maysa

“…Long noncoding ribonucleic acids (lncRNAs), small noncoding RNAs known as microRNAs (miRNAs) as well as some cytokines are recently thought to have a role in…”
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Design, synthesis, and pharmacological characterization of some 2‐substituted‐3‐phenyl‐quinazolin‐4(3H)‐one derivatives as phosphodiesterase inhibitors by Amin, Kamilia M., Hegazy, Gehan H., George, Riham F., Ibrahim, Nahla R., Mohamed, Nada M.

“…Some 3‐phenyl‐quinazolin‐4(3H)‐one‐2‐thioethers (3a–e, 5a,b, 7a–e, 9a–d, 10a–d, and 12) along with 2‐aminoquinazoline derivatives 13a–c were prepared and…”
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Synthesis, docking and biological activities of novel hybrids celecoxib and anthraquinone analogs as potent cytotoxic agents by Almutairi, Maha S, Hegazy, Gehan H, Haiba, Mogedda E, Ali, Hamed I, Khalifa, Nagy M, Soliman, Abd El-mohsen M

“…Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesized using condensation reactions of celecoxib with…”
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Hepatoprotective effect of Moringa oleifera extract on TNF-α and TGF-β expression in acetaminophen-induced liver fibrosis in rats by Aly, Omnia, Abouelfadl, Dalia M, Shaker, Olfat G, Hegazy, Gehan A, Fayez, Ahmed M, Zaki, Hanan Hassan

“…BackgroundIt has been reported that Moringa oleifera (MO) has different medicinal properties. The aim of this study was to evaluate the hepatoprotective role…”
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Significance of Interleukin 23 in Systemic Lupus Patients: Relation to Disease Activity and Damage Indices by Haroon, Maysa M, Hegazy, Gehan A, Hassanien, Mohammed A, Shaker, Olfat, Hussein, Wafaa H

“…Dysregulation of both cellular and humoral immune responses is central in systemic lupus erythematosus (SLE) pathogenetic mechanisms. Proinflammatory…”
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Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors by Al-Ashmawy, Aisha A.K., Ragab, Fatma A., Elokely, Khaled M., Anwar, Manal M., Perez-Leal, Oscar, Rico, Mario C., Gordon, John, Bichenkov, Eugeney, Mateo, George, Kassem, Emad M.M., Hegazy, Gehan H., Abou-Gharbia, Magid, Childers, Wayne

“…[Display omitted] PI3Kα/mTOR ATP-competitive inhibitors are considered as one of the promising molecularly targeted cancer therapeutics. Based on lead compound…”
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