Search Results - "Hegazy, Ahmed N."

Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism by Haghikia, Arash, Zimmermann, Friederike, Schumann, Paul, Jasina, Andrzej, Roessler, Johann, Schmidt, David, Heinze, Philipp, Kaisler, Johannes, Nageswaran, Vanasa, Aigner, Annette, Ceglarek, Uta, Cineus, Roodline, Hegazy, Ahmed N, van der Vorst, Emiel P C, Döring, Yvonne, Strauch, Christopher M, Nemet, Ina, Tremaroli, Valentina, Dwibedi, Chinmay, Kränkel, Nicolle, Leistner, David M, Heimesaat, Markus M, Bereswill, Stefan, Rauch, Geraldine, Seeland, Ute, Soehnlein, Oliver, Müller, Dominik N, Gold, Ralf, Bäckhed, Fredrik, Hazen, Stanley L, Haghikia, Aiden, Landmesser, Ulf

“…Abstract Aims Atherosclerotic cardiovascular disease (ACVD) is a major cause of mortality and morbidity worldwide, and increased low-density lipoproteins…”
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T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses by Baumann, Claudia, Bonilla, Weldy V., Fröhlich, Anja, Helmstetter, Caroline, Peine, Michael, Hegazy, Ahmed N., Pinschewer, Daniel D., Löhning, Max

“…Significance The alarmin IL-33 amplifies immune responses of Th2 and CD8 ⁺ cytotoxic T cells against invading pathogens; however, little is known about a…”
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IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release by Siede, Julia, Fröhlich, Anja, Datsi, Angeliki, Hegazy, Ahmed N, Varga, Domonkos V, Holecska, Vivien, Saito, Hirohisa, Nakae, Susumu, Löhning, Max

“…Immunomodulatory Foxp3+ regulatory T cells (Tregs) form a heterogeneous population consisting of subsets with different activation states, migratory properties…”
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Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis by Gámez-Belmonte, Reyes, Wagner, Yara, Mahapatro, Mousumi, Wang, Ru, Erkert, Lena, González-Acera, Miguel, Cineus, Roodline, Hainbuch, Saskia, Patankar, Jay V., Voehringer, David, Hegazy, Ahmed N., Neurath, Markus F., Wirtz, Stefan, Becker, Christoph

“…Gasdermin C is one of the least studied members of the gasdermin family of proteins, known for their critical involvement in pyroptosis and host defense…”
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Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation by Peine, Michael, Rausch, Sebastian, Helmstetter, Caroline, Fröhlich, Anja, Hegazy, Ahmed N, Kühl, Anja A, Grevelding, Christoph G, Höfer, Thomas, Hartmann, Susanne, Löhning, Max

“…Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th…”
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Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells by Burt, Philipp, Peine, Michael, Peine, Caroline, Borek, Zuzanna, Serve, Sebastian, Floßdorf, Michael, Hegazy, Ahmed N., Höfer, Thomas, Löhning, Max, Thurley, Kevin

“…Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving…”
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Anti-SARS-CoV2 antibody-mediated cytokine release syndrome in a patient with acute promyelocytic leukemia by Hegazy, Ahmed N, Krönke, Jan, Angermair, Stefan, Schwartz, Stefan, Weidinger, Carl, Keller, Ulrich, Treskatsch, Sascha, Siegmund, Britta, Schneider, Thomas

“…Passive immunization against SARS-CoV-2 limits viral burden and death from COVID-19; however, it poses a theoretical risk of disease exacerbation through…”
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Individual T Helper Cells Have a Quantitative Cytokine Memory by Helmstetter, Caroline, Flossdorf, Michael, Peine, Michael, Kupz, Andreas, Zhu, Jinfang, Hegazy, Ahmed N., Duque-Correa, Maria A., Zhang, Qin, Vainshtein, Yevhen, Radbruch, Andreas, Kaufmann, Stefan H., Paul, William E., Höfer, Thomas, Löhning, Max

“…The probabilistic expression of cytokine genes in differentiated T helper (Th) cell populations remains ill defined. By single-cell analyses and mathematical…”
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Accurate identification and quantification of commensal microbiota bound by host immunoglobulins by Jackson, Matthew A, Pearson, Claire, Ilott, Nicholas E, Huus, Kelsey E, Hegazy, Ahmed N, Webber, Jonathan, Finlay, B Brett, Macpherson, Andrew J, Powrie, Fiona, Lam, Lilian H

“…Identifying which taxa are targeted by immunoglobulins can uncover important host-microbe interactions. Immunoglobulin binding of commensal taxa can be assayed…”
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Aggravation of viral hepatitis by platelet-derived serotonin by Zinkernagel, Rolf M, Lang, Karl S, Lang, Philipp A, Contaldo, Claudio, Georgiev, Panco, El-Badry, Ashraf Mohammad, Recher, Mike, Kurrer, Michael, Cervantes-Barragan, Luisa, Ludewig, Burkhard, Calzascia, Thomas, Bolinger, Beatrice, Merkler, Doron, Odermatt, Bernhard, Bader, Michael, Graf, Rolf, Clavien, Pierre-Alain, Hegazy, Ahmed N, Löhning, Max, Harris, Nicola L, Ohashi, Pamela S, Hengartner, Hans

“…More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic,…”
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Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression by Bergthaler, Andreas, Flatz, Lukas, Hegazy, Ahmed N., Johnson, Susan, Horvath, Edit, Löhning, Max, Pinschewer, Daniel D., Zinkernagel, Rolf M.

“…The Clone 13 (Cl13) strain of lymphocytic choriomeningitis virus is widely studied as a model of chronic systemic viral infection. Here, we used reverse…”
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Impaired antibody response causes persistence of prototypic T cell-contained virus by Bergthaler, Andreas, Flatz, Lukas, Verschoor, Admar, Hegazy, Ahmed N, Holdener, Martin, Fink, Katja, Eschli, Bruno, Merkler, Doron, Sommerstein, Rami, Horvath, Edit, Fernandez, Marylise, Fitsche, André, Senn, Beatrice M, Verbeek, J Sjef, Odermatt, Bernhard, Siegrist, Claire-Anne, Pinschewer, Daniel D

“…CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators…”
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Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation by Miragaia, Ricardo J., Gomes, Tomás, Chomka, Agnieszka, Jardine, Laura, Riedel, Angela, Hegazy, Ahmed N., Whibley, Natasha, Tucci, Andrea, Chen, Xi, Lindeman, Ida, Emerton, Guy, Krausgruber, Thomas, Shields, Jacqueline, Haniffa, Muzlifah, Powrie, Fiona, Teichmann, Sarah A.

“…Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to…”
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Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage by Bhattacharya, Anannya, Hegazy, Ahmed N., Deigendesch, Nikolaus, Kosack, Lindsay, Cupovic, Jovana, Kandasamy, Richard K., Hildebrandt, Andrea, Merkler, Doron, Kühl, Anja A., Vilagos, Bojan, Schliehe, Christopher, Panse, Isabel, Khamina, Kseniya, Baazim, Hatoon, Arnold, Isabelle, Flatz, Lukas, Xu, Haifeng C., Lang, Philipp A., Aderem, Alan, Takaoka, Akinori, Superti-Furga, Giulio, Colinge, Jacques, Ludewig, Burkhard, Löhning, Max, Bergthaler, Andreas

“…Tissue damage caused by viral hepatitis is a major cause of morbidity and mortality worldwide. Using a mouse model of viral hepatitis, we…”
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The alarmin IL-33 promotes regulatory T-cell function in the intestine by Schiering, Chris, Krausgruber, Thomas, Chomka, Agnieszka, Fröhlich, Anja, Adelmann, Krista, Wohlfert, Elizabeth A., Pott, Johanna, Griseri, Thibault, Bollrath, Julia, Hegazy, Ahmed N., Harrison, Oliver J., Owens, Benjamin M. J., Löhning, Max, Belkaid, Yasmine, Fallon, Padraic G., Powrie, Fiona

“…The alarmin interleukin-33 is constitutively expressed at barrier sites and released in response to tissue damage; here, the IL-33 receptor ST2 is shown to be…”
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Microbiota RORgulates intestinal suppressor T cells by Hegazy, Ahmed N, Powrie, Fiona

“…Gut microbes influence the balance of regulatory T cell subtypes to control inflammation [Also see Reports by Ohnmacht et al. and Sefik et al. ] The immune…”
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Take my breath away—mitochondrial dysfunction drives CD8+ T cell exhaustion by Richter, Felix Clemens, Saliutina, Mariia, Hegazy, Ahmed N., Bergthaler, Andreas

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The role of adipose tissue in inflammatory bowel diseases by Weidinger, Carl, Hegazy, Ahmed N, Siegmund, Britta

“…PURPOSE OF REVIEWThe occurrence of creeping fat wrapping segments of inflamed gut represents a characteristic yet incompletely understood hallmark of Crohnʼs…”
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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease by West, Nathaniel R, Hegazy, Ahmed N, Owens, Benjamin M J, Bullers, Samuel J, Linggi, Bryan, Buonocore, Sofia, Coccia, Margherita, Görtz, Dieter, This, Sébastien, Stockenhuber, Krista, Pott, Johanna, Friedrich, Matthias, Ryzhakov, Grigory, Baribaud, Frédéric, Brodmerkel, Carrie, Cieluch, Constanze, Rahman, Nahid, Müller-Newen, Gerhard, Owens, Raymond J, Kühl, Anja A, Maloy, Kevin J, Plevy, Scott E, Keshav, Satish, Travis, Simon P L, Powrie, Fiona

“…The cytokine oncostatin M drives intestinal inflammation in mice, and its abundance in the intestine of patients with inflammatory bowel disease predicts…”
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Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation by Hegazy, Ahmed N., West, Nathaniel R., Stubbington, Michael J.T., Wendt, Emily, Suijker, Kim I.M., Datsi, Angeliki, This, Sebastien, Danne, Camille, Campion, Suzanne, Duncan, Sylvia H., Owens, Benjamin M.J., Uhlig, Holm H., McMichael, Andrew, Bergthaler, Andreas, Teichmann, Sarah A., Keshav, Satish, Powrie, Fiona

“…Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these…”
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