The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer

The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer

The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound use...

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Bibliographic Details
Published in:Gene Vol. 647; pp. 235 - 243
Main Authors: Shafei, Ayman, Ramzy, Maggie M., Hegazy, Abdelhares I., Husseny, Ahmed K., EL-hadary, Usama G., Taha, Mazen M., Mosa, Ali A.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 20-03-2018
Subjects:
Bisphenol A
Cancer
Endocrine disrupting chemicals
Epigenetics
Molecular signaling
BMP
ERβ
EDC
ERα
Molecular signaling
HBOC
Endocrine disrupting chemicals
DNMT
MMP
Bisphenol A
BPA
PCOS
Epigenetics
miRNA
TNBC
Cancer
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Summary:The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound used in the production of water bottles, cans, and teeth suture materials. It is known to be a xenoestrogen as it interacts with estrogen receptors and acts as agonist or antagonist via estrogen receptor-dependent signaling pathways. BPA has been associated with serious health effects in humans and wildlife. It elicits several endocrine disorders and plays a role in the pathogenesis of several hormone-dependent tumors such as breast, ovarian, prostate cancer and others. More complicate to this picture, its effects rely on several and diverse molecular and epigenetic mechanisms that converge upon endocrine and reproductive systems. The present review gives an overview of general hazards of BPA, its epigenetic modifications and the molecular mechanisms of BPA action in different types of cancers as the increase in information about responses and action mechanisms of BPA may bring a better understanding of the risks of BPA exposure in humans and provide an important platform on which human health can be improved. •BPA is a very common hormone-disrupting substance that acts as a xenoestrogen.•BPA increases the incidence and susceptibility to neoplastic transformations.•Prenatal exposure to BPA may increase the propensity to develop cancer during adulthood.•BPA exposure causes epigenetic modifications affecting gene expression.•BPA has many molecular singling in different types of cancers.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2018.01.016