Search Results - "Hegarty, Shauna"

Cathepsin S from both tumor and tumor‐associated cells promote cancer growth and neovascularization by Small, Donna M., Burden, Roberta E., Jaworski, Jakub, Hegarty, Shauna M., Spence, Shaun, Burrows, James F., McFarlane, Cheryl, Kissenpfennig, Adrien, McCarthy, Helen O., Johnston, James A., Walker, Brian, Scott, Christopher J.

“…Recent murine studies have demonstrated that tumor‐associated macrophages in the tumor microenvironment are a key source of the pro‐tumorigenic cysteine…”
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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis by Lindsay, Colin R., Lawn, Samuel, Campbell, Andrew D., Faller, William J., Rambow, Florian, Mort, Richard L., Timpson, Paul, Li, Ang, Cammareri, Patrizia, Ridgway, Rachel A., Morton, Jennifer P., Doyle, Brendan, Hegarty, Shauna, Rafferty, Mairin, Murphy, Ian G., McDermott, Enda W., Sheahan, Kieran, Pedone, Katherine, Finn, Alexander J., Groben, Pamela A., Thomas, Nancy E., Hao, Honglin, Carson, Craig, Norman, Jim C., Machesky, Laura M., Gallagher, William M., Jackson, Ian J., Van Kempen, Leon, Beermann, Friedrich, Der, Channing, Larue, Lionel, Welch, Heidi C., Ozanne, Brad W., Sansom, Owen J.

“…Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular…”
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Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis by BURDEN, Roberta E, GORMLEY, Julie A, SCOTT, Christopher J, JAQUIN, Thomas J, SMALL, Donna M, QUINN, Derek J, HEGARTY, Shauna M, WARD, Claire, WALKER, Brian, JOHNSTON, James A, OLWILL, Shane A

“…Purpose: Cathepsin S is a cysteine protease that promotes the invasion of tumor and endothelial cells during cancer progression. Here we investigated the…”
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A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung by Glasgow, Arlene M A, Small, Donna M, Scott, Aaron, McLean, Denise T, Camper, Nicolas, Hamid, Umar, Hegarty, Shauna, Parekh, Dhruv, O'Kane, Cecilia, Lundy, Fionnuala T, McNally, Paul, Elborn, J Stuart, McAuley, Danny F, Weldon, Sinéad, Taggart, Clifford C

“…Secretory leucocyte protease inhibitor and elafin are members of the whey acidic protein (WAP), or WAP four disulfide-core (WFDC), family of proteins and have…”
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Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis by Faller, William J, Rafferty, Mairin, Hegarty, Shauna, Gremel, Gabriela, Ryan, Denise, Fraga, Mario F, Esteller, Manel, Dervan, Peter A, Gallagher, William M

“…DNA methylation plays a major role in cancer by silencing tumour suppressor genes. In melanoma, only a discrete number of methylated genes have been identified…”
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Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis by Ryan, Denise, Rafferty, Mairin, Hegarty, Shauna, O'Leary, Patrick, Faller, William, Gremel, Gabriela, Bergqvist, Michael, Agnarsdottir, Margret, Strömberg, Sara, Kampf, Caroline, Pontén, Fredrik, Millikan, Robert C., Dervan, Peter A., Gallagher, William M.

“…Summary In this study, we used array‐comparative genomic hybridization (aCGH) and fluorescent in situ hybridization (FISH) to examine genetic aberrations in…”
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Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo by Vicente-Perez, Eva M., Larrañeta, Eneko, McCrudden, Maelíosa T.C., Kissenpfennig, Adrien, Hegarty, Shauna, McCarthy, Helen O., Donnelly, Ryan F.

“…[Display omitted] We address, for the first time, the impact of skin insertion on multiple occasions of polymeric microneedle arrays in an animal model in…”
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Increased claudin‐4 expression is associated with poor prognosis and high tumour grade in breast cancer by Lanigan, Fiona, McKiernan, Eadaoin, Brennan, Donal J., Hegarty, Shauna, Millikan, Robert C., McBryan, Jean, Jirstrom, Karin, Landberg, Goran, Martin, Finian, Duffy, Michael J., Gallagher, William M.

“…The role of intercellular tight junctions in breast epithelial cells is traditionally thought to be in maintaining polarity and barrier function. However,…”
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CENP‐F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer by O'Brien, Sallyann L., Fagan, Ailís, Fox, Edward J.P., Millikan, Robert C., Culhane, Aedín C., Brennan, Donal J., McCann, Amanda H., Hegarty, Shauna, Moyna, Siobhan, Duffy, Michael J., Higgins, Desmond G., Jirström, Karin, Landberg, Göran, Gallagher, William M.

“…DNA microarrays have the potential to classify tumors according to their transcriptome. Tissue microarrays (TMAs) facilitate the validation of biomarkers by…”
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The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL by McKeen, Hayley D, Brennan, Donal J, Hegarty, Shauna, Lanigan, Fiona, Jirstrom, Karin, Byrne, Christopher, Yakkundi, Anita, McCarthy, Helen O, Gallagher, William M, Robson, Tracy

“…FKBPs (FK506-binding proteins) have long been recognized as key regulators of the response to immunosuppressant drugs and as co-chaperones of steroid receptor…”
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FKBPL: a marker of good prognosis in breast cancer by Nelson, Laura, McKeen, Hayley D, Marshall, Andrea, Mulrane, Laoighse, Starczynski, Jane, Storr, Sarah J, Lanigan, Fiona, Byrne, Christopher, Arthur, Ken, Hegarty, Shauna, Ali, Ahlam Abdunnabi, Furlong, Fiona, McCarthy, Helen O, Ellis, Ian O, Green, Andrew R, Rakha, Emad, Young, Leonie, Kunkler, Ian, Thomas, Jeremy, Jack, Wilma, Cameron, David, Jirström, Karin, Yakkundi, Anita, McClements, Lana, Martin, Stewart G, Gallagher, William M, Dunn, Janet, Bartlett, John, O'Connor, Darran, Robson, Tracy

“…FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering…”
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Abstract 4402: Fsn0503: A novel therapeutic antibody for the treatment of colorectal cancer by Gormley, Julie A., Olwill, Shane A., Hegarty, Shauna M., Scott, Christopher J., Burden, Roberta E., Johnston, James A., Kay, Elaine W.

“…Abstract Local invasion and metastasis is the primary cause of death in many cancers. Extracellular matrix degradation by proteolytic enzymes facilitates…”
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