Search Results - "Hegarty, John P."

Advances in therapeutic bacterial antisense biotechnology by Hegarty, John P., Stewart, David B.

“…Antisense therapeutics are a biotechnological form of antibiotic therapy using chemical analogues of short single-stranded nucleic acid sequences modified to…”
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Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation–Inhibition Balance in Autism Spectrum Disorder by Hegarty, John P., Weber, Dylan J., Cirstea, Carmen M., Beversdorf, David Q.

“…Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism…”
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Genetic and environmental influences on structural brain measures in twins with autism spectrum disorder by Hegarty, John P., Pegoraro, Luiz F. L., Lazzeroni, Laura C., Raman, Mira M., Hallmayer, Joachim F., Monterrey, Julio C., Cleveland, Sue C., Wolke, Olga N., Phillips, Jennifer M., Reiss, Allan L., Hardan, Antonio Y.

“…Atypical growth patterns of the brain have been previously reported in autism spectrum disorder (ASD) but these alterations are heterogeneous across…”
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Effects of stress on functional connectivity during problem solving by Nair, Neetu, Hegarty, John P., Ferguson, Bradley J., Hecht, Patrick M., Tilley, Michael, Christ, Shawn E., Beversdorf, David Q.

“…Our purpose was to examine how stress affects functional connectivity (FC) in language processing regions of the brain during a verbal problem solving task…”
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Genetic and environmental influences on corticostriatal circuits in twins with autism by Hegarty II, John P., Lazzeroni, Laura C., Raman, Mira M., Hallmayer, Joachim F., Cleveland, Sue C., Wolke, Olga N., Phillips, Jennifer M., Reiss, Allan L., Hardan, Antonio Y.

“…Corticostriatal circuits (CSC) have been implicated in the presentation of some restricted and repetitive behaviours (RRBs) in children with autism-spectrum…”
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The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients by Schieffer, Kathleen M., Sabey, Kate, Wright, Justin R., Toole, David R., Drucker, Rebecca, Tokarev, Vasily, Harris, Leonard R., Deiling, Sue, Eshelman, Melanie A., Hegarty, John P., Yochum, Gregory S., Koltun, Walter A., Lamendella, Regina, Stewart, David B.

“…Diverticular disease is commonly associated with the older population in the United States. As individual’s age, diverticulae, or herniation of the mucosa…”
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Erythropoietin-PLGA-PEG as a local treatment to promote functional recovery and neurovascular regeneration after peripheral nerve injury by Manto, Kristen M, Govindappa, Prem Kumar, Martinazzi, Brandon, Han, Aijie, Hegarty, John P, Koroneos, Zachary, Talukder, M A Hassan, Elfar, John C

“…Traumatic peripheral nerve injury (TPNI) is a major medical problem with no universally accepted pharmacologic treatment. We hypothesized that encapsulation of…”
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Beta-adrenergic antagonism alters functional connectivity during associative processing in a preliminary study of individuals with and without autism by Hegarty, John P, Zamzow, Rachel M, Ferguson, Bradley J, Christ, Shawn E, Porges, Eric C, Johnson, Jeffrey D, Beversdorf, David Q

“…Beta-adrenergic antagonism (e.g. propranolol) has been associated with cognitive/behavioral benefits following stress-induced impairments and for some…”
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Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study by Sangster, William, Hegarty, John P, Schieffer, Kathleen M, Wright, Justin R, Hackman, Jada, Toole, David R, Lamendella, Regina, Stewart, Sr, David B

“…This study sought to characterize the bacterial and fungal microbiota changes associated with Clostridium difficile infection (CDI) among inpatients with…”
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Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile by Sharma, Arun K., Krzeminski, Jacek, Weissig, Volkmar, Hegarty, John P., Stewart, David B.

“…Conventional antibiotics for C. difficile infection (CDI) have mechanisms of action without organismal specificity, potentially perpetuating the dysbiosis…”
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Morphological differences in the lateral geniculate nucleus associated with dyslexia by Giraldo-Chica, Mónica, Hegarty, 2nd, John P, Schneider, Keith A

“…Developmental dyslexia is a common learning disability characterized by normal intelligence but difficulty in skills associated with reading, writing and…”
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A Twin Study of Altered White Matter Heritability in Youth With Autism Spectrum Disorder by Hegarty, 2nd, John P, Monterrey, Julio C, Tian, Qiyuan, Cleveland, Sue C, Gong, Xinyi, Phillips, Jennifer M, Wolke, Olga N, McNab, Jennifer A, Hallmayer, Joachim F, Reiss, Allan L, Hardan, Antonio Y, Lazzeroni, Laura C

“…White matter alterations are frequently reported in autism spectrum disorder (ASD), yet the etiology is currently unknown. The objective of this investigation…”
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Correlation between virulence gene expression and proton pump inhibitors and ambient pH in Clostridium difficile: results of an in vitro study by STEWART, David B, HEGARTY, John P

“…Proton pump inhibitors (PPIs) are associated with the development of Clostridium difficile infection in humans. Though it is assumed that PPIs mediate this…”
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Phage tail-like particles kill Clostridium difficile and represent an alternative to conventional antibiotics by Sangster, William, MD, Hegarty, John P., PhD, Stewart, David B., MD, FACS, FASCRS

“…Background Current Clostridium difficile infection (CDI) antibiotic regimens have become increasingly ineffective at achieving cure and preventing recurrence…”
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Altered gut microbiota composition with antibiotic treatment impairs functional recovery after traumatic peripheral nerve crush injury in mice: effects of probiotics with butyrate producing bacteria by Rodenhouse, Andrew, Talukder, M A Hassan, Lee, Jung Il, Govindappa, Prem Kumar, O'Brien, Mary, Manto, Kristen M, Lloyd, Kelsey, Wandling, Grant D, Wright, Justin R, Chen See, Jeremy R, Anderson, Samantha L, Lamendella, Regina, Hegarty, John P, Elfar, John C

“…Antibiotics (ABX) are widely used for life-threatening infections and also for routine surgical operations. Compelling evidence suggests that ABX-induced…”
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Proton pump inhibitors induce changes in colonocyte gene expression that may affect Clostridium difficile infection by Hegarty, John P., PhD, Sangster, William, MD, Harris, Leonard R., BSc, Stewart, David B., MD

“…Background Proton pump inhibitors seem to promote Clostridium difficile infection (CDI). Although the current literature suggests that this association is…”
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A proton MR spectroscopy study of the thalamus in twins with autism spectrum disorder by Hegarty, John P., Gu, Meng, Spielman, Daniel M., Cleveland, Sue C., Hallmayer, Joachim F., Lazzeroni, Laura C., Raman, Mira M., Frazier, Thomas W., Phillips, Jennifer M., Reiss, Allan L., Hardan, Antonio Y.

“…Multiple lines of research have reported thalamic abnormalities in individuals with autism spectrum disorder (ASD) that are associated with social…”
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An interleukin-4 polymorphism is associated with susceptibility to Clostridium difficile infection in patients with inflammatory bowel disease: Results of a retrospective cohort study by Connelly, Tara M., MB, BCh, MS, Koltun, Walter A., MD, Sangster, William, MD, Berg, Arthur S., PhD, Hegarty, John P., PhD, Harris, Leonard, BS, Deiling, Susan, BA, Stewart, David B., MD

“…Background Clinical studies have suggested that patients with inflammatory bowel disease (IBD) are at greater risk for developing Clostridium difficile…”
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Functional recovery and muscle atrophy in pre-clinical models of peripheral nerve transection and gap-grafting in mice: effects of 4-aminopyridine by Lee, Jung, Talukder, M, Karuman, Zara, Gurjar, Anagha, Govindappa, Prem, Guddadarangaiah, Jagadeeshaprasad, Manto, Kristen, Wandling, Grant, Hegarty, John, Waning, David, Elfar, John

“…We recently demonstrated a repurposing beneficial effect of 4-aminopyridine (4-AP), a potassium channel blocker, on functional recovery and muscle atrophy…”
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NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells by Yu, Wei, Hegarty, John P, Berg, Arthur, Chen, Xi, West, Gail, Kelly, Ashley A, Wang, Yunhua, Poritz, Lisa S, Koltun, Walter A, Lin, Zhenwu

“…NKX2-3 is associated with inflammatory bowel disease (IBD). NKX2-3 is expressed in microvascular endothelial cells and the muscularis mucosa of the…”
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