Search Results - "Hegardt, C."

Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic by Winter, C., Nilsson, M.P., Olsson, E., George, A.M., Chen, Y., Kvist, A., Törngren, T., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Jönsson, G., Grabau, D., Malmberg, M., Kristoffersson, U., Rehn, M., Gruvberger-Saal, S.K., Larsson, C., Borg, Å., Loman, N., Saal, L.H.

“…A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and…”
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Minimizing inequality in access to precision medicine in breast cancer by real‐time population‐based molecular analysis in the SCAN‐B initiative by Rydén, L., Loman, N., Larsson, C., Hegardt, C., Vallon‐Christersson, J., Malmberg, M., Lindman, H., Ehinger, A., Saal, L. H., Borg, Å.

“…Background Selection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are…”
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119 Breast cancer stem cell selectivity of nanomolar-active salinomycin analogs by Huang, X, Borgström, B, Kempengren, S, Persson, L, Hegardt, C, Oredsson, S

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52P RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer by Vallon-Christersson, J., Staaf, J., Häkkinen, J., Hegardt, C., Saal, L., Ehinger, A., Larsson, C., Loman, N., Rydén, L., Malmberg, M., Borg, Å.

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Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers by Glodzik, Dominik, Bosch, Ana, Hartman, Johan, Aine, Mattias, Vallon-Christersson, Johan, Reuterswärd, Christel, Karlsson, Anna, Mitra, Shamik, Niméus, Emma, Holm, Karolina, Häkkinen, Jari, Hegardt, Cecilia, Saal, Lao H., Larsson, Christer, Malmberg, Martin, Rydén, Lisa, Ehinger, Anna, Loman, Niklas, Kvist, Anders, Ehrencrona, Hans, Nik-Zainal, Serena, Borg, Åke, Staaf, Johan

“…Homologous recombination deficiency (HRD) is a defining characteristic in BRCA -deficient breast tumors caused by genetic or epigenetic alterations in key…”
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Abstract PD2-08: Predictors of axillary nodal metastasis based on gene expression and clinicopathological characteristics: Data from a population-based prospective study, the Sweden Cancerome Analysis Network – Breast (SCAN-B) by Dihge, L, Staaf, J, Vallon-Christersson, J, Hegardt, C, Häkkinen, J, Borg, Å, Rydén, L

“…Abstract Background Gene expression patterns show promise in estimating prognosis and directing adjuvant therapy, but its significance in guiding axillary…”
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RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer by Vallon-Christersson, J., Staaf, J., Häkkinen, J., Hegardt, C., Saal, L., Ehinger, A., Larsson, C., Loman, N., Rydén, L., Malmberg, M., Borg, Å.

“…BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on…”
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Abstract P3-02-02: Concordance between immunohistochemical and gene-expression based subtyping of early breast cancer using core needle biopsies and surgical specimens - experices from SCAN-B by Morgan, G, Larsson, C, Tahin, B, Vallon-Christersson, J, Häkkinen, J, Ehinger, A, Malmberg, M, Hegardt, C, Borg, Å, Rydén, L, Saal, LH, Hedenfalk, I, Loman, N

“…Abstract Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information…”
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Abstract P1-06-01: Putting multigene signatures to the test: Prognostic assessment in population-based contemporary clinical breast cancer by Staaf, J, Vallon-Christersson, J, Häkkinen, J, Saal, LH, Hegardt, C, Larsson, C, Ehinger, A, Ryden, L, Loman, N, Malmberg, M, Borg, Å

“…Abstract Background Gene expression signatures hold promise for a molecularly driven division of primary breast cancer with clinical implications. A gap still…”
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Abstract P4-09-03: On the development and clinical value of RNA-sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter SCAN-B study by Brueffer, C, Vallon-Christersson, J, Grabau, D, Ehinger, A, Häkkinen, J, Hegardt, C, Malina, J, Chen, Y, Bendahl, P-O, Manjer, J, Malmberg, M, Larsson, C, Loman, N, Ryden, L, Borg, Å, Saal, LH

“…Abstract Background: In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and…”
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Abstract P2-02-09: Breast cancer subtype distribution and circulating tumor DNA in response to neoadjuvant chemotherapy: Experiences from a preoperative cohort within SCAN-B by Loman, N, Chen, Y, Aaltonen, K, Brueffer, C, George, AM, Zander, L, Vallon-Christersson, J, Häkkinen, J, Förnvik, D, Rigo, R, Ehinger, A, Malmberg, M, Larsson, C, Hegardt, C, Borg, Å, Rydén, L, Saal, LH

“…Abstract Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information. In the…”
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Abstract P1-07-17: The SCAN-B study: 5-year summary of a large-scale population-based prospective breast cancer translational genomics platform covering a wide geography of Sweden (NCT02306096) by Saal, LH, Hegardt, C, Vallon-Christersson, J, Häkkinen, J, Ehinger, A, Manjer, J, Larsson, C, Loman, N, Rydén, L, Malmberg, M, Borg, Å

“…Abstract Background: Breast cancer exhibits significant molecular, pathological, and clinical heterogeneity. Current clinicopathological evaluation is…”
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Induction of apoptotic cell death by putrescine by Takao, Koichi, Rickhag, Mattias, Hegardt, Cecilia, Oredsson, Stina, Persson, Lo

“…The polyamines are essential for cellular growth and differentiation. Ornithine decarboxylase (ODC), which catalyses the first step in the biosynthesis of the…”
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Dealing with disasters by Hegardt, Christian

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Reduction of the putative CD44 super(+)CD24 super(-) breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047 by Cirenajwis, H, Smiljanic, S, Honeth, G, Hegardt, C, Marton, L J, Oredsson, S M

“…Cancer stem cells (CSCs) are considered to be of particular concern in cancer as they possess inherent properties of self-renewal and differentiation, along…”
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P3-06-08: SCAN-B: An Accelerated Translational Pipeline from Profile to Prognosis and Prediction for Individual Breast Cancer Patients by Loman, N, Saal, LH, Häkkinen, J, Vallon-Christersson, J, Ringnér, M, Hegardt, C, Jönsson, G, Gruvberger-Saal, SK, Kvist, A, Reuterswärd, C, Schulz, R, Karlsson, A, Jönsson, M, Grabau, D, Manjer, J, Carlson, J, Malina, J, Larsson, C, Rydén, L, Borg, Å

“…Abstract The South Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative is a multidisciplinary network of clinical providers of breast cancer (BC)…”
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Different cell cycle kinetic effects of N super(1),N super(11)-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines by Myhre, L, Alm, K, Hegardt, C, Staaf, J, Joensson, G, Larsson, S, Oredsson, S M

“…Polyamine analogues are presently undergoing clinical evaluation in the treatment of cancer. To better understand under what circumstances treatment with a…”
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Intratumor versus intertumor heterogeneity in gene expression profiles of soft-tissue sarcomas by Francis, Princy, Fernebro, Josefin, Edén, Patrik, Laurell, Anna, Rydholm, Anders, Domanski, Henryk A., Breslin, Thomas, Hegardt, Cecilia, Borg, Åke, Nilbert, Mef

“…Soft‐tissue sarcomas (STSs) constitute more than 30 histologic entities. In addition, within each entity, tumors are often heterogeneous in macroscopic…”
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Different Roles of Spermine in Glucocorticoid- and Fas-Induced Apoptosis by Hegardt, Cecilia, Andersson, Gunnar, Oredsson, Stina M.

“…Two experimental systems representative of the mitochondrial and death receptor apoptotic pathways are the dexamethasone-induced programmed cell death in mouse…”
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Spermine prevents cytochrome c release in glucocorticoid-induced apoptosis in mouse thymocytes by Hegardt, Cecilia, Andersson, Gunnar, Oredsson, Stina M

“…Apoptosis can be induced in primary cultures of mouse thymocytes using the glucocorticoid dexamethasone. Addition of the polyamine spermine simultaneously with…”
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