Search Results - "Hefty, P. Scott"

Chlamydia trachomatis -containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense by Fischer, Annette, Harrison, Kelly S, Ramirez, Yesid, Auer, Daniela, Chowdhury, Suvagata Roy, Prusty, Bhupesh K, Sauer, Florian, Dimond, Zoe, Kisker, Caroline, Hefty, P Scott, Rudel, Thomas

“…Obligate intracellular replicate in a membrane-bound vacuole called inclusion, which serves as a signaling interface with the host cell. Here, we show that the…”
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A conserved C-terminal domain of TamB interacts with multiple BamA POTRA domains in Borreliella burgdorferi by Hall, Kari T, Kenedy, Melisha R, Johnson, David K, Hefty, P Scott, Akins, Darrin R

“…Lyme disease is the leading tick-borne infection in the United States, caused by the pathogenic spirochete Borreliella burgdorferi, formerly known as Borrelia…”
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Conditional gene expression in Chlamydia trachomatis using the tet system by Wickstrum, Jason, Sammons, Lindsay R, Restivo, Keasha N, Hefty, P Scott

“…Chlamydia trachomatis is maintained through a complex bi-phasic developmental cycle that incorporates numerous processes that are poorly understood. This is…”
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Sigma 54-Regulated Transcription Is Associated with Membrane Reorganization and Type III Secretion Effectors during Conversion to Infectious Forms of Chlamydia trachomatis by Soules, Katelyn R., LaBrie, Scott D., May, Benjamin H., Hefty, P. Scott

“…The factors that control the growth and infectious processes for Chlamydia are still poorly understood. This study used recently developed genetic tools to…”
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Simple Resazurin-Based Microplate Assay for Measuring Chlamydia Infections by OSAKA, Ichie, HEFTY, P. Scott

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Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer by LaBrie, Scott D, Dimond, Zoë E, Harrison, Kelly S, Baid, Srishti, Wickstrum, Jason, Suchland, Robert J, Hefty, P Scott

“…Transposon mutagenesis is a widely applied and powerful genetic tool for the discovery of genes associated with selected phenotypes. is a clinically…”
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QAUST: Protein Function Prediction Using Structure Similarity, Protein Interaction, and Functional Motifs by Smaili, Fatima Zohra, Tian, Shuye, Roy, Ambrish, Alazmi, Meshari, Arold, Stefan T., Mukherjee, Srayanta, Hefty, P. Scott, Chen, Wei, Gao, Xin

“…The number of available protein sequences in public databases is increasing exponentially. However, a significant percentage of these sequences lack functional…”
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Small-Molecule Inhibitor of the Shigella flexneri Master Virulence Regulator VirF by Koppolu, Veerendra, Osaka, Ichie, Skredenske, Jeff M, Kettle, Bria, Hefty, P Scott, Li, Jiaqin, Egan, Susan M

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A CURE for the COVID-19 Era: A Vaccine-Focused Online Immunology Laboratory by Baid, Srishti, Hefty, P Scott, Morgan, Dyan E

“…During the COVID-19 pandemic, universities across the globe quickly shifted to online education. Laboratory courses faced unique challenges and were forced to…”
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Chlamydial Type III Secretion System Is Encoded on Ten Operons Preceded by Sigma 70-Like Promoter Elements by HEFTY, P. Scott, STEPHENS, Richard S

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An Automated Image-Based Method for Rapid Analysis of Chlamydia Infection as a Tool for Screening Antichlamydial Agents by OSAKA, Ichie, HILLS, Jeffrey M, KIEWEG, Sarah L, SHINOGLE, Heather E, MOORE, David S, SCOTT HEFTY, P

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Global Analysis of Borrelia burgdorferi Genes Regulated by Mammalian Host-Specific Signals by BROOKS, Chad S, HEFTY, P. Scott, JOLLIFF, Sarah E, AKINS, Darrin R

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The Loss of Expression of a Single Type 3 Effector (CT622) Strongly Reduces Chlamydia trachomatis Infectivity and Growth by Cossé, Mathilde M, Barta, Michael L, Fisher, Derek J, Oesterlin, Lena K, Niragire, Béatrice, Perrinet, Stéphanie, Millot, Gaël A, Hefty, P Scott, Subtil, Agathe

“…Invasion of epithelial cells by the obligate intracellular bacterium results in its enclosure inside a membrane-bound compartment termed an inclusion. The…”
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The Atypical OmpR/PhoB Response Regulator ChxR from Chlamydia trachomatis Forms Homodimers In Vivo and Binds a Direct Repeat of Nucleotide Sequences by HICKEY, John M, WELDON, Lindsey, HEFTY, P. Scott

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Computational modeling of TC0583 as a putative component of the Chlamydia muridarum V-type ATP synthase complex and assessment of its protective capabilities as a vaccine antigen by Tifrea, Delia F., Barta, Michael L., Pal, Sukumar, Hefty, P. Scott, de la Maza, Luis M.

“…Numerous Chlamydia trachomatis proteins have been identified as potential subunit vaccines, of which the major outer-membrane protein (MOMP) has, so far,…”
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Atypical response regulator ChxR from Chlamydia trachomatis is structurally poised for DNA binding by Barta, Michael L, Hickey, John M, Anbanandam, Asokan, Dyer, Kevin, Hammel, Michal, Hefty, P Scott

“…ChxR is an atypical two-component signal transduction response regulator (RR) of the OmpR/PhoB subfamily encoded by the obligate intracellular bacterial…”
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Ab Initio Structural Modeling of and Experimental Validation for Chlamydia trachomatis Protein CT296 Reveal Structural Similarity to Fe(II) 2-Oxoglutarate-Dependent Enzymes by Kemege, Kyle E, Hickey, John M, Lovell, Scott, Battaile, Kevin P, Zhang, Yang, Hefty, P. Scott

“…Chlamydia trachomatis is a medically important pathogen that encodes a relatively high percentage of proteins with unknown function. The three-dimensional…”
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Comprehensive genome analysis and comparisons of the swine pathogen, Chlamydia suis reveals unique ORFs and candidate host-specificity factors by Dimond, Zoe E, Hefty, P Scott

“…ABSTRACT Chlamydia suis, a ubiquitous swine pathogen, has the potential for zoonotic transmission to humans and often encodes for resistance to the primary…”
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Fructose-1-kinase has pleiotropic roles in Escherichia coli by Weeramange, Chamitha, Menjivar, Cindy, O’Neil, Pierce T., El Qaidi, Samir, Harrison, Kelly S., Meinhardt, Sarah, Bird, Cole L., Sreenivasan, Shwetha, Hardwidge, Philip R., Fenton, Aron W., Hefty, P. Scott, Bose, Jeffrey L., Swint-Kruse, Liskin

“…In Escherichia coli, the master transcription regulator catabolite repressor activator (Cra) regulates >100 genes in central metabolism. Cra binding to DNA is…”
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Chromosomal Recombination Targets in Chlamydia Interspecies Lateral Gene Transfer by Suchland, Robert J, Carrell, Steven J, Wang, Yibing, Hybiske, Kevin, Kim, Debbie B, Dimond, Zoe E, Hefty, P Scott, Rockey, Daniel D

“…Lateral gene transfer (LGT) among strains is common, in both isolates generated in the laboratory and those examined directly from patients. In contrast, there…”
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