Search Results - "Hefta, Stanley A"

Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database by Omenn, Gilbert S., States, David J., Adamski, Marcin, Blackwell, Thomas W., Menon, Rajasree, Hermjakob, Henning, Apweiler, Rolf, Haab, Brian B., Simpson, Richard J., Eddes, James S., Kapp, Eugene A., Moritz, Robert L., Chan, Daniel W., Rai, Alex J., Admon, Arie, Aebersold, Ruedi, Eng, Jimmy, Hancock, William S., Hefta, Stanley A., Meyer, Helmut, Paik, Young-Ki, Yoo, Jong-Shin, Ping, Peipei, Pounds, Joel, Adkins, Joshua, Qian, Xiaohong, Wang, Rong, Wasinger, Valerie, Wu, Chi Yue, Zhao, Xiaohang, Zeng, Rong, Archakov, Alexander, Tsugita, Akira, Beer, Ilan, Pandey, Akhilesh, Pisano, Michael, Andrews, Philip, Tammen, Harald, Speicher, David W., Hanash, Samir M.

“…HUPO initiated the Plasma Proteome Project (PPP) in 2002. Its pilot phase has (1) evaluated advantages and limitations of many depletion, fractionation, and MS…”
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In Vitro Biomarker Discovery for Atherosclerosis by Proteomics by Fach, Estelle M, Garulacan, Leah-Ann, Gao, Ji, Xiao, Qing, Storm, Stephen M, Dubaquie, Yves P, Hefta, Stanley A, Opiteck, Gregory J

“…The purpose of this study was to identify in vitro and then prioritize a tractable set of protein biomarker candidates of atherosclerosis that may eventually…”
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Identification of in vitro protein biomarkers of idiosyncratic liver toxicity by Gao, Ji, Ann Garulacan, Leah, Storm, Stephen M, Hefta, Stanley A, Opiteck, Gregory J, Lin, Jun-Hsiang, Moulin, Frederic, Dambach, Donna M

“…Drug-induced idiosyncratic hepatotoxicity continues to be an important safety issue for the pharmaceutical industry. This toxicity is due, in part, to the…”
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Changes in the Protein Expression of Yeast as a Function of Carbon Source by Gao, Ji, Opiteck, Gregory J, Friedrichs, Mark S, Dongre, Ashok R, Hefta, Stanley A

“…Protein expression trends in yeast were monitored as a function of carbon source (glucose versus galactose) using multidimensional high performance liquid…”
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Biomarker Discovery in Urine by Proteomics by Pang, James X, Ginanni, Nicole, Dongre, Ashok R, Hefta, Stanley A, Opiteck, Gregory J

“…A hypothesis was formed that it would be possible to isolate an adequate amount of protein from a patient, having normal renal function, to identify biological…”
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Biomarker discovery in biological fluids by Gao, Ji, Garulacan, Leah-Ann, Storm, Stephen M., Opiteck, Gregory J., Dubaquie, Yves, Hefta, Stanley A., Dambach, Donna M., Dongre, Ashok R.

“…Discovery of novel protein biomarkers is essential for successful drug discovery and development. These novel protein biomarkers may aid accelerated drug…”
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A Microscale Electrospray Interface for Online, Capillary Liquid Chromatography/Tandem Mass Spectrometry of Complex Peptide Mixtures by Davis, Michael T, Stahl, Douglas C, Hefta, Stanley A, Lee, Terry D

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Time-Resolved Limited Proteolysis of Mitogen-Activated Protein Kinase-Activated Protein Kinase-2 Determined by LC/MS Only by Tao, Li, Kiefer, Susan E., Xie, Dianlin, Bryson, James W., Hefta, Stanley A., Doyle, Michael L.

“…Mass spectrometry has gained prominence in limited proteolysis studies largely due to its unparalleled precision in determining protein molecular mass…”
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A high-yield method to extract peptides from rat brain tissue by Kline, Tiffany R, Pang, James, Hefta, Stanley A, Opiteck, Gregory J, Kiefer, Susan E, Scheffler, Julie E

“…A process to extract and enrich extracellular peptides and proteins from tissues should have broad utility in the burgeoning proteomics field. To address this…”
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Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification by Kasuya, Junko, Paz, I. Benjamin, Maddux, Betty A, Goldfine, Ira D, Hefta, Stanley A, Fujita-Yamaguchi, Yoko

“…Protein microsequencing of human placental IGF-I receptors purified by immunoaffinity chromatography using IGF-I receptor specific monoclonal antibody revealed…”
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Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA) by Leusch, Hans-Georg, Hefta, Stanley A., Drzeniek, Zofia, Hummel, Klaus, Markos-Pusztai, Zsuzanna, Wagener, Christoph

“…Immobilized carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA) bound 3 strains of E. coli of human origin. The binding was dose…”
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Article: Time-Resolved Limited Proteolysis of Mitogen-Activated Protein Kinase-Activated Protein Kinase-2 Determined by LC/MS Only by Tao, Li, Kiefer, Susan E, Xie, Dianlin, Bryson, James W, Hefta, Stanley A, Doyle, Michael L

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Semi-Automated Sample Preparation for Plasma Proteomics by Ho, Keith, Xiao, Qing, Fach, Estelle M., Hulmes, Jeffrey D., Bethea, Deidra, Opiteck, Gregory J., Lu, Joseph Y., Kayne, Paul S., Hefta, Stanley A.

“…The discovery of new biomarkers will be an essential step to enhance our ability to better diagnose and treat human disease. The proteomics research community…”
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Proteomics in the post-genome age by Dongre, Ashok R., Opiteck, Gregory, Cosand, Wesley L., Hefta, Stanley A.

“…The genome sequencing effort has helped spawn the burgeoning field of proteomics. This review article examines state‐of‐the‐art proteomics methods that are…”
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Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor by Enghild, J J, Salvesen, G, Hefta, S A, Thøgersen, I B, Rutherfurd, S, Pizzo, S V

“…The human blood protein pre-alpha-inhibitor is composed of one heavy and one light protein chain. The chains are covalently linked to each other by a structure…”
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Isolation and sequence of an active-site peptide containing a catalytic aspartic acid from two Streptococcus sobrinus alpha-glucosyltransferases by MOOSER, G, HEFTA, S. A, PAXTON, R. J, SHIVELY, J. E, LEE, T. D

“…An active-site peptide containing an aspartic acid implicated in catalysis has been isolated and sequenced from two Streptococcus sobrinus extracellular…”
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Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin by ENGHILD, J. J, SALVESEN, G, THØGERSEN, I. B, VALNICKOVA, Z, PIZZO, S. V, HEFTA, S. A

“…HC2/bikunin is a human plasma proteinase inhibitor composed of two polypeptide chains that resist dissociation under reducing conditions in SDS-polyacrylamide…”
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Purification, characterization, gene sequence, and significance of a bacterioferritin from Mycobacterium leprae by PESSOLANI, M. C. V, SMITH, D. R, RIVOIRE, B, MCCORMICK, J, HEFTA, S. A, COLE, S. T, BRENNAN, P. J

“…The study of tissue-derived Mycobacterium leprae provides insights to the immunopathology of leprosy and helps identify broad molecular features necessary for…”
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Molecular cloning of a cDNA Coding Biliary Glycoprotein I: Primary Structure of a Glycoprotein Immunologically Crossreactive with Carcinoembryonic Antigen by Hinoda, Yuji, Neumaier, Michael, Hefta, Stanley A., Drzeniek, Zofia, Wagener, Christoph, Shively, Louise, Laura J. F. Hefta, Shively, John E., Paxton, Raymond J.

“…We have isolated and sequenced four over-lapping cDNA clones from a normal adult human colon library, which together gave the entire nucleotide sequence for…”
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Microscale Immobilized Protease Reactor Columns for Peptide Mapping by Liquid Chromatography/Mass Spectral Analyses by Davis, M.T., Lee, T.D., Ronk, M., Hefta, S.A.

“…Methods and procedures for the construction and operation of a microscale immobilized protease (trypsin) reactor are described. Optimization of reactor…”
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