Search Results - "Heffron, J J A"

n-Hexane toxicity in Jurkat T-cells is mediated by reactive oxygen species by McDermott, Catherine, O’Donoghue, Maria Hutch, Heffron, James J. A.

“…Here we assess the role of reactive oxygen species (ROS) formation in the manifestation of n -hexane toxicity in Jurkat T-cells and the chemo-protective…”
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In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: Results of testing patients surviving fulminant MH and unrelated low-risk subjects by ØRDING, H., BRANCADORO, V., COZZOLINO, S., ELLIS, F. R., GLAUBER, V., GONANO, E. F., HALSALL, P. J., HARTUNG, E., HEFFRON, J. J. A., HEYTENS, L., KOZAK-RIBBENS, G., KRESS, H., KRTVOSIC-HORBER, R., LEHMANN-HORN, F., MORTIER, W., NIVOCHE, Y., RANKLEV-TWETMAN, E., SIGURDSSON, S., SNOECK, M., STIEGLITZ, P., TEGAZZIN, V., URWYLER, A., WAPPLER, F.

“…Background: Determination of sensitivity and specificity of the in vitro contracture test (IVCT) for malignant hyperthermia (MH) susceptibility using the…”
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A Mutation in the Transmembrane/Luminal Domain of the Ryanodine Receptor Is Associated with Abnormal Ca2+Release Channel Function and Severe Central Core Disease by Lynch, Patrick J., Tong, Jiefei, Lehane, Mary, Mallet, Alejandro, Giblin, Linda, James J. A. Heffron, Vaughan, Pat, Zafra, Gildardo, MacLennan, David H., McCarthy, Tommie V.

“…Central core disease is a rare, nonprogressive myopathy that is characterized by hypotonia and proximal muscle weakness. In a large Mexican kindred with an…”
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3,4-Methylenedioxymethamphetamine (ecstasy) activates skeletal muscle nicotinic acetylcholine receptors by Klingler, Werner, Heffron, James J A, Jurkat-Rott, Karin, O'sullivan, Grainne, Alt, Andreas, Schlesinger, Friedrich, Bufler, Johannes, Lehmann-Horn, Frank

“…Adverse 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) effects are usually ascribed to neurotransmitter release in the central nervous system. Since…”
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Macrosomia prediction using ultrasound fetal abdominal circumference of 35 centimeters or more by Jazayeri, Allahyar, Heffron, Julia A, Phillips, Rosemary, Spellacy, William N

“…Objective: To determine if birth weights greater than 4000 g can be predicted by ultrasound measurements of abdominal circumferences. Methods: In 1996, 254…”
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Sub-chronic toxicity of low concentrations of industrial volatile organic pollutants in vitro by McDermott, Catherine, Allshire, Ashley, van Pelt, Frank N.A.M., Heffron, James J.A.

“…Organic solvents form an important class of pollutants in the ambient air and have been associated with neurotoxicity and immunotoxicity in humans. Here we…”
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In Vitro Exposure of Jurkat T-Cells to Industrially Important Organic Solvents in Binary Combination: Interaction Analysis by McDermott, Catherine, Allshire, Ashley, van Pelt, Frank, Heffron, James J. A.

“…Humans are frequently exposed to mixtures of environmental pollutants at low levels over prolonged periods of time yet most toxicity studies deal with acute…”
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Localization of the malignant hyperthermia susceptibility locus to human chromosome 19ql2-13.2 by McCarthy, Tommie V, Healy, J. M. Sandra, Heffron, James J. A, Lehane, Mary, Deufel, Thomas, Lehmann-Horn, Frank, Farrall, Martin, Johnson, Keith

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Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle by Glover, Louise, Heffron, James J. A, Ohlendieck, Kay

“…1 Department of Pharmacology, University College Dublin, Belfield, Dublin 4, Ireland; 2 Irish Malignant Hyperthermia Diagnostic Centre, Department of…”
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Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility by Wappler, F, Anetseder, M, Baur, C P, Censier, K, Doetsch, S, Felleiter, P, Fiege, M, Fricker, R, Halsall, P J, Hartung, E, Heffron, J J A, Heytens, L, Hopkins, P M, Klingler, W, Lehmann-Horn, F, Nivoche, Y, Tegazzin, V, Tzanova, I, Urwyler, A, Weisshorn, R, Schulte am Esch, J

“…The in vitro contracture test with halothane and caffeine is the gold standard for the diagnosis of susceptibility to malignant hyperthermia (MH). However, the…”
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Validation of a method for acute and subchronic exposure of cells in vitro to volatile organic solvents by McDermott, Catherine, Allshire, Ashley, van Pelt, Frank N.A.M., Heffron, James J.A.

“…In vitro assessment of organic solvents can be problematic as the volatile nature of these compounds makes maintaining a constant exposure level difficult…”
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Toxicity of Industrially Relevant Chlorinated Organic Solvents In Vitro by McDermott, Catherine, Heffron, James J.A.

“…The cytotoxic effects of 4 industrially important chlorinated organic solvents, dichloromethane (DCM), 1,2-dichloroethane (DCE), trichloroethylene (TCE), and…”
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Antepartum and postpartum Papanicolaou smears : Are they both necessary? by JAZAYERI, A, HEFFRON, J. A, HARNETTY, P, JAZAYERI, M, GOULD, S. F

“…To determine if a Papanicolaou smear performed during pregnancy needs to be repeated at the postpartum visit. A retrospective chart review was performed on…”
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Monitoring and assessment of a research student's project by Heffron, J J

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Reactive nonstress test despite severe congenital brain damage : What does the test measure? by CARDOSI, R. J, HEFFRON, J. A, SPELLACY, W. N

“…Antenatal testing with the nonstress test is common in the evaluation of high-risk pregnancies. A reactive test gives the clinician reassurance of fetal…”
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Choice of nuclear technology and legislative certainty for nuclear safety and liability in Turkey by Heffron, R. J. A., Hatino lu, B.

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Using a pattern recognition approach to link inorganic chemical fingerprints of ambient PM2.5–0.1 with in vitro biological effects by Healy, David A., Hellebust, Stig, Silvari, Virginia, Lopez, José M., Whittaker, Andrew G., Wenger, John C., Heffron, James J. A., Sodeau, John R.

“…Atmospheric fine particulates act as prime vehicles for the transport of toxic chemicals into the human respiratory system on a daily basis and adverse human…”
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Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2 by MCCARTHY, T. V, HEALY, J. M. S, HEFFRON, J. J. A, LEHANE, M, DEUFEL, T, LEHMANN-HORN, F, FARRALL, M, JOHNSON, K

“…Malignant hyperthermia (MH) is an inherited human skeletal muscle disorder and is one of the main causes of death due to anaesthesia. The reported incidence of…”
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Implications of seasonal priming and reproductive activity on the interpretation of Comet assay data derived from the clam, Tapes semidecussatus Reeves 1864, exposed to contaminated sediments by Hartl, M.G.J., Coughlan, B.M., Sheehan, D., Mothersill, C., van Pelt, F.N.A.M., O'Reilly, S.J., Heffron, J.J.A., O'Halloran, J., O'Brien, N.M.

“…We explore the use of the clam Tapes semidecussatus Reeves 1864 as an indicator for the presence of potentially genotoxic substances in estuarine sediments…”
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Minister's boson by Heffron, James J. A

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