Search Results - "Heffner, T.G."

The pharmacology of the novel and selective sigma ligand, PD 144418 by AKUNNE, H. C, WHETZEL, S. Z, WILEY, J. N, CORBIN, A. E, NINTEMAN, F. W, TECLE, H, PEI, Y, PUGSLEY, T. A, HEFFNER, T. G

“…The pharmacology of PD 144418 (1-propyl-5-(3-p-tolyl-isoxazol-5-yl)-1,2,3,6-tetrahydropyridine) was characterized using neurochemical, biochemical and…”
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Synthesis of catecholamines from [3H]tyrosine in brain during the performance of operant behavior by Heffner, T G, Seiden, L S

“…Changes in the synthesis rates of dopamine (DA) and norepinephrine (NE) in brain were found to accompany the performance of positively reinforced operant…”
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PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT 1A agonist actions. II. Preclinical behavioral effects by Corbin, A.E, Meltzer, L.T, Ninteman, F.W, Wiley, J.N, Christoffersen, C.L, Wustrow, D.J, Wise, L.D, Pugsley, T.A, Heffner, T.G

“…PD 158771 has been described in receptor binding and biochemical tests as a partial agonist at dopamine (DA) D2 and D3 receptors as well as an agonist at…”
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PD 158771, a potential antipsychotic agent with D 2/D 3 partial agonist and 5-HT 1A agonist actions. I. Neurochemical effects by Akunne, H.C, Zoski, K.T, Davis, M.D, Cooke, L.W, Meltzer, L.T, Whetzel, S.Z, Shih, Y.H, Wustrow, D.J, Wise, L.D, MacKenzie, R.G, Georgic, L.M, Heffner, T.G, Pugsley, T.A

“…The neurochemical effects of a novel dopamine (DA) D 2-like and serotonin (5-HT) 5-HT 1A agonist, PD 158771, are described. PD 158771 exhibited affinities for…”
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PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT1A agonist actions. II. Preclinical behavioral effects by CORBIN, A. E, MELTZER, L. T, NINTEMAN, F. W, WILEY, J. N, CHRISTOFFERSEN, C. L, WUSTROW, D. J, WISE, L. D, PUGSLEY, T. A, HEFFNER, T. G

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Reduced amide bond neurotensin 8–13 mimetics with potent in vivo activity by Wustrow, D.J., Davis, M.D., Akunne, H.C., Corbin, A.E., Wiley, J.N., Wise, L.D., Heffner, T.G.

“…Appropriately substituted 8–9 (ΨCH 2NH) isosteres of neurotensin (NT) 8–13 have been found which are active as NT agonists in vitro and in vivo. SAR studies…”
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PD 158771, a potential antipsychotic agent with D2/D3 partial agonist and 5-HT1A agonist actions. I. Neurochemical effects by AKUNNE, H. C, ZOSKI, K. T, GEORGIC, L. M, HEFFNER, T. G, PUGSLEY, T. A, DAVIS, M. D, COOKE, L. W, MELTZER, L. T, WHETZEL, S. Z, SHIH, Y. H, WUSTROW, D. J, WISE, L. D, MACKENZIE, R. G

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Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists by Pugsley, T.A., Akunne, H.C., Whetzel, S.Z., Demattos, S., Corbin, A.E., Wiley, J.N., Wustrow, D.J., Wise, L.D., Heffner, T.G.

“…In in vitro studies, SR 48692, a nonpeptide neurotensin receptor antagonist, inhibited the binding of [ 3H] or [ 125I]neurotensin to membrane preparations from…”
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Novel small molecule neurotensin antagonists: 3-(1,5-diaryl-1,5-dioxopentan-3-yl)benzoic acids by Johnson, S.J., Akunne, H.C., Heffner, T.G., Kesten, S.R., Pugsley, T.A., Wise, L.D., Wustrow, D.J.

“…Screening in a neurotensin (NT) receptor binding assay resulted in the discovery of compound 1 with NT receptor binding affinity of 450 nM. SAR studies that…”
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Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents by Sebolt-Leopold, J S, Vincent, P W, Beningo, K A, Elliott, W L, Leopold, W R, Heffner, T G, Wiley, J N, Stier, M A, Suto, M J

“…RB 6145, the ring-opened analog of RSU 1069, and PD 130908, the desoxy ring-opened analog of RSU 1069, were compared to RSU 1069 for their emetic potential in…”
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Lack of involvement of haloperidol-sensitive sigma binding sites in modulation of dopamine neuronal activity and induction of dystonias by antipsychotic drugs by Meltzer, L T, Christoffersen, C L, Serpa, K A, Pugsley, T A, Razmpour, A, Heffner, T G

“…The present studies evaluated previous suggestions that haloperidol-sensitive sigma binding sites are involved in the modulation of dopamine (DA) neuronal…”
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The effect of water-deprivation on locomotor activity in rats treated with 6-hydroxydopamine by Seiden, L S, Pachman, S H, Heffner, T G, Shaughnessy, R A, Vosmer, G

“…Male albino rats treated with 6-hydroxydopamine (6-OHDA) became more hyperactive than did vehicle-treated controls when both groups were water-deprived. Rats…”
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Locomotor hyperactivity in neonatal rats following electrolytic lesions of mesocortical dopamine neurons by Heffner, T G, Heller, A, Miller, F E, Kotake, C, Seiden, L S

“…These experiments examined the effects on locomotor activity of brain lesions that destroyed either mesocortical or nigrostriatal dopamine (DA) neuronal…”
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