Search Results - "Hefeneider, Steven H."

A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice by Tsung, Allan, McCoy, Sharon L, Klune, John R, Geller, David A, Billiar, Timothy R, Hefeneider, Steven H

“…Sepsis resulting from gram-negative bacterial infections is characterized by an excessive inflammatory immune response initiated by exposure of the host innate…”
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Upregulation of multiple toll-like receptors in ferret brain after blast exposure: Potential targets for treatment by Govindarajulu, Manoj, Patel, Mital Y., Wilder, Donna M., Krishnan, Jishnu, LaValle, Christina, Pandya, Jignesh D., Shear, Deborah A., Hefeneider, Steven H., Long, Joseph B., Arun, Peethambaran

“…•Blast exposure upregulated multiple TLRs in the brain of ferrets.•Differential expression of TLRs varied in different brain regions post-blast…”
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Activation of RAW264.7 Macrophages by Bacterial DNA and Lipopolysaccharide Increases Cell Surface DNA Binding and Internalization by McCoy, Sharon L., Kurtz, Stephen E., Hausman, Frances A., Trune, Dennis R., Bennett, Robert M., Hefeneider, Steven H.

“…Bacterial DNA containing unmethylated CpG motifs is a pathogen-associated molecular pattern (PAMP) that interacts with host immune cells via a toll-like…”
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C3H/HeJ Mouse Model for Spontaneous Chronic Otitis Media by MacArthur, Carol J., Hefeneider, Steven H., Kempton, J Beth, Trune, Dennis R.

“…Objectives/Hypothesis: Chronic otitis media is a significant clinical problem. Understanding the mechanisms of chronic otitis media is critical for its…”
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Failure of elevated heat shock protein 70 antibodies to alter cochlear function in mice by Trune, Dennis R, Kempton, J.Beth, Mitchell, Curtin R, Hefeneider, Steven H

“…Heat shock protein 70 (HSP70) has been suggested as the putative cochlear antigen underlying a proposed autoimmune etiology in certain cases of Meniere's…”
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Identification of a Peptide Derived from Vaccinia Virus A52R Protein That Inhibits Cytokine Secretion in Response to TLR-Dependent Signaling and Reduces In Vivo Bacterial-Induced Inflammation by McCoy, Sharon L, Kurtz, Stephen E, MacArthur, Carol J, Trune, Dennis R, Hefeneider, Steven H

“…TLRs recognize and respond to conserved motifs termed pathogen-associated molecular patterns. TLRs are characterized by an extracellular leucine-rich repeat…”
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Evaluation of the mouse model for acute otitis media by MacArthur, Carol J., Hefeneider, Steven H., Kempton, J. Beth, Parrish, Sarah K., McCoy, Sharon L., Trune, Dennis R.

“…Various animal models have been employed for otitis media research. The mouse has been studied less, in spite of its many advantages. To better understand the…”
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A Human Gene Coding for a Membrane-associated Nucleic Acid-binding Protein by Siess, Don C., Vedder, Colleen T., Merkens, Louise S., Tanaka, Toshiko, Freed, Alison C., McCoy, Sharon L., Heinrich, Michael C., Deffebach, Mark E., Bennett, Robert M., Hefeneider, Steven H.

“…Studies to clone a cell-surface DNA-binding protein involved in the binding and internalization of extracellular DNA have led to the isolation of a gene for a…”
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Autoimmune mouse antibodies recognize multiple antigens proposed in human immune-mediated hearing loss by Hefeneider, Steven H, McCoy, Sharon L, Hausman, Frances A, Trune, Dennis R

“…Autoimmune diseased mice with hearing loss will have autoantibodies against the various cochlear antigens proposed in clinical autoimmune inner ear disease…”
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Long-term effects of 60-Hz electric vs. magnetic fields on IL-1 and IL-2 activity in sheep by Hefeneider, Steven H., McCoy, Sharon L., Hausman, Frances A., Christensen, Heidi L., Takahashi, Diana, Perrin, Nancy, Bracken, T. Dan, Shin, K.Y., Hall, Arthur S.

“…This study was designed to assess the effect of exposure to long‐term extremely low‐frequency electric and magnetic fields (ELF–EMF) from a 500 kV transmission…”
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Identification of a Cell-Surface DNA Receptor and Its Association with Systemic Lupus Erythematosus by Hefeneider, Steven H, Bennett, Robert M, Pham, Tuan Q, Cornell, Kenneth, McCoy, Sharon L, Heinrich, Michael C

“…We have previously reported the existence of a cell-membrane-associated molecule on human PBMC, which binds DNA and has the characteristics of a receptor…”
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DNA binding to mouse cells is mediated by cell-surface molecules: the role of these DNA-binding molecules as target antigens in murine lupus by Hefeneider, S H, McCoy, S L, Morton, J I, Bakke, A C, Cornell, K A, Brown, L E, Bennett, R M

“…Autoimmunity to a 28-29-kDa cell-surface DNA-binding molecule has previously been described in patients with systemic lupus erythematosus and related…”
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A novel inhibitory peptide of Toll-like receptor signaling limits LPS-induced production of inflammatory mediators and enhances survival in mice (89.12) by Hefeneider, Steven H, McCoy, Sharon L, Billiar, Timothy R, Tsung, Allan

“…Sepsis resulting from gram-negative bacterial infections is characterized by an excessive inflammatory immune response initiated by exposure of the host innate…”
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Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production by Hefeneider, S H, Cornell, K A, Brown, L E, Bakke, A C, McCoy, S L, Bennett, R M

“…The molecular basis for the cellular interaction of DNA and nucleosomes and the physiological consequences of this binding were examined. Both DNA and…”
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Steroid treatment improves cochlear function in the MRL.MpJ-Fas(lpr) autoimmune mouse by Trune, D R, Wobig, R J, Kempton, J B, Hefeneider, S H

“…Corticosteroid therapy is used to reverse autoimmune sensorineural hearing loss, although little is known of the mechanism by which this occurs. This has been…”
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Steroid treatment in young MRL.MpJ-Fas(lpr) autoimmune mice prevents cochlear dysfunction by Trune, D R, Wobig, R J, Kempton, J B, Hefeneider, S H

“…Corticosteroid therapy reverses clinical autoimmune sensorineural hearing loss, although little is known of how steroids restore normal auditory function. If…”
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Decreased Cochlear DNA Receptor Staining in MRL.MpJ-Faslpr Autoimmune Mice With Hearing Loss by Kaylie, David M., Hefeneider, Steven H., Kempton, J. Beth, Siess, Don C., Vedder, Colleen T., Merkens, Louise S., Trune, Dennis R.

“…Objectives Previous studies of decreased cochlear DNA binding in autoimmune mice suggested that antibodies against a cochlear cell surface DNA receptor cause…”
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Decreased Cochlear DNA Receptor Staining in MRL.MpJ‐ Fas lpr Autoimmune Mice With Hearing Loss by Kaylie, David M., Hefeneider, Steven H., Kempton, J. Beth, Siess, Don C., Vedder, Colleen T., Merkens, Louise S., Trune, Dennis R.

“…Objectives Previous studies of decreased cochlear DNA binding in autoimmune mice suggested that antibodies against a cochlear cell surface DNA receptor cause…”
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Steroid treatment in young MRL.MpJ- Fas lpr autoimmune mice prevents cochlear dysfunction by Trune, Dennis R., Wobig, Roger J., Kempton, J.Beth, Hefeneider, Steven H.

“…Corticosteroid therapy reverses clinical autoimmune sensorineural hearing loss, although little is known of how steroids restore normal auditory function. If…”
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Steroid treatment improves cochlear function in the MRL.MpJ- Fas lpr autoimmune mouse by Trune, Dennis R., Wobig, Roger J., Kempton, J.Beth, Hefeneider, Steven H.

“…Corticosteroid therapy is used to reverse autoimmune sensorineural hearing loss, although little is known of the mechanism by which this occurs. This has been…”
Get full text