Search Results - "Hefeneider, SH"

Identification of a Peptide Derived from Vaccinia Virus A52R Protein That Inhibits Cytokine Secretion in Response to TLR-Dependent Signaling and Reduces In Vivo Bacterial-Induced Inflammation by McCoy, Sharon L, Kurtz, Stephen E, MacArthur, Carol J, Trune, Dennis R, Hefeneider, Steven H

“…TLRs recognize and respond to conserved motifs termed pathogen-associated molecular patterns. TLRs are characterized by an extracellular leucine-rich repeat…”
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DNA binding to mouse cells is mediated by cell-surface molecules: the role of these DNA-binding molecules as target antigens in murine lupus by Hefeneider, S H, McCoy, S L, Morton, J I, Bakke, A C, Cornell, K A, Brown, L E, Bennett, R M

“…Autoimmunity to a 28-29-kDa cell-surface DNA-binding molecule has previously been described in patients with systemic lupus erythematosus and related…”
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Activation of RAW264.7 Macrophages by Bacterial DNA and Lipopolysaccharide Increases Cell Surface DNA Binding and Internalization by McCoy, Sharon L., Kurtz, Stephen E., Hausman, Frances A., Trune, Dennis R., Bennett, Robert M., Hefeneider, Steven H.

“…Bacterial DNA containing unmethylated CpG motifs is a pathogen-associated molecular pattern (PAMP) that interacts with host immune cells via a toll-like…”
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A Human Gene Coding for a Membrane-associated Nucleic Acid-binding Protein by Siess, Don C., Vedder, Colleen T., Merkens, Louise S., Tanaka, Toshiko, Freed, Alison C., McCoy, Sharon L., Heinrich, Michael C., Deffebach, Mark E., Bennett, Robert M., Hefeneider, Steven H.

“…Studies to clone a cell-surface DNA-binding protein involved in the binding and internalization of extracellular DNA have led to the isolation of a gene for a…”
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Autoimmune mouse antibodies recognize multiple antigens proposed in human immune-mediated hearing loss by Hefeneider, Steven H, McCoy, Sharon L, Hausman, Frances A, Trune, Dennis R

“…Autoimmune diseased mice with hearing loss will have autoantibodies against the various cochlear antigens proposed in clinical autoimmune inner ear disease…”
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Steroid treatment improves cochlear function in the MRL.MpJ-Fas(lpr) autoimmune mouse by Trune, D R, Wobig, R J, Kempton, J B, Hefeneider, S H

“…Corticosteroid therapy is used to reverse autoimmune sensorineural hearing loss, although little is known of the mechanism by which this occurs. This has been…”
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Steroid treatment in young MRL.MpJ-Fas(lpr) autoimmune mice prevents cochlear dysfunction by Trune, D R, Wobig, R J, Kempton, J B, Hefeneider, S H

“…Corticosteroid therapy reverses clinical autoimmune sensorineural hearing loss, although little is known of how steroids restore normal auditory function. If…”
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Failure of elevated heat shock protein 70 antibodies to alter cochlear function in mice by Trune, Dennis R, Kempton, J.Beth, Mitchell, Curtin R, Hefeneider, Steven H

“…Heat shock protein 70 (HSP70) has been suggested as the putative cochlear antigen underlying a proposed autoimmune etiology in certain cases of Meniere's…”
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Decreased cochlear DNA receptor staining in MRL.MpJ-Fas(lpr) autoimmune mice with hearing loss by Kaylie, D M, Hefeneider, S H, Kempton, J B, Siess, D C, Vedder, C T, Merkens, L S, Trune, D R

“…Previous studies of decreased cochlear DNA binding in autoimmune mice suggested that antibodies against a cochlear cell surface DNA receptor cause autoimmune…”
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Inner ear DNA receptors in MRL/lpr autoimmune mice: potential 30 and 70 kDa link between autoimmune disease and hearing loss by Trune, Dennis R., Kempton, J. Beth, Hefeneider, Steven H., Bennett, Robert M.

“…Inner ear function and systemic autoimmune disease were evaluated in the MRL/lpr mouse to determine their relationship with alterations in cell surface DNA…”
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Quantification of DNA binding to cell-surfaces by flow cytometry by McCoy, Sharon L., Hausman, Frances A., Deffebach, Mark E., Bakke, Antony, Merkens, Louise S., Bennett, Robert M., Hefeneider, Steven H.

“…DNA binding to cell-surfaces has been documented in several studies. The interaction of DNA with cells has been shown to have therapeutic potential as a…”
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Long-term effects of 60-Hz electric vs. magnetic fields on IL-1 and IL-2 activity in sheep by Hefeneider, Steven H., McCoy, Sharon L., Hausman, Frances A., Christensen, Heidi L., Takahashi, Diana, Perrin, Nancy, Bracken, T. Dan, Shin, K.Y., Hall, Arthur S.

“…This study was designed to assess the effect of exposure to long‐term extremely low‐frequency electric and magnetic fields (ELF–EMF) from a 500 kV transmission…”
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In vivo interleukin 2 administration augments the generation of alloreactive cytolytic T lymphocytes and resident natural killer cells by Hefeneider, SH, Conlon, PJ, Henney, CS, Gillis, S

“…Interleukin 2 (IL 2) is a T cell growth factor that has been shown to modulate several in vitro immune responses. Produced by T cells, the lymphokine has been…”
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The modulation of human aortic endothelial cell ICAM-1 (CD-54) expression by serum containing high titers of anti-HLA antibodies by Hosenpud, J D, Shipley, G D, Morris, T E, Hefeneider, S H, Wagner, C R

“…Allograft recipients who have preformed antibodies to MHC determinants or develop these antibodies post-transplantation have a higher incidence of cellular…”
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Autoimmunity to a 28–30 kD cell membrane DNA binding protein: occurrence in selected sera from patients with SLE and mixed connective tissue disease (MCTD) by BENNETT, R. M., CORNELL, K. A., MERRITT, M. J., BAKKE, A. C., HSU, P. H., HEFENEIDER, S. H.

“…SUMMARY Previous experiments have established the presence of a 30‐kD DNA binding protein on the surface of human leukocytes. Herein we report that selected…”
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Molecular characterization of interleukin 2 by Gillis, S, Mochizuki, D Y, Conlon, P J, Hefeneider, S H, Ramthun, C A, Gillis, A E, Frank, M B, Henney, C S, Watson, J D

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Time course and contact dependence of allogeneic lymphocyte-induced human aortic endothelial cell-derived interleukin-6 by Morris, T E, Shipley, G D, Wagner, C R, Hefeneider, S H, Hosenpud, J D

“…Vascular endothelial cells secrete the pluripotent cytokine interleukin-6, and the induction of this secretion can be regulated by a number of other…”
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The production and characterization of murine monoclonal antibodies to a DNA receptor on human leukocytes by Bennet, RM, Hefeneider, SH, Bakke, A, Merritt, M, Smith, CA, Mourich, D, Heinrich, MC

“…Two murine mAb have been generated with a reactivity toward a 30,000 m.w. DNA binding protein found on the cell surface of human leukocytes; mAb 12A has an…”
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Identification of a Cell-Surface DNA Receptor and Its Association with Systemic Lupus Erythematosus by Hefeneider, Steven H, Bennett, Robert M, Pham, Tuan Q, Cornell, Kenneth, McCoy, Sharon L, Heinrich, Michael C

“…We have previously reported the existence of a cell-membrane-associated molecule on human PBMC, which binds DNA and has the characteristics of a receptor…”
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Recombinant murine and human IL 1 alpha bind to human endothelial cells with an equal affinity, but have an unequal ability to induce endothelial cell adherence of lymphocytes by Thieme, TR, Hefeneider, SH, Wagner, CR, Burger, DR

“…Consistent with the reports of others, we have demonstrated that human peripheral blood lymphocytes adhere to cultured human umbilical vein-derived endothelial…”
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