Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK

Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of converge...

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Bibliographic Details
Published in:	The EMBO journal Vol. 23; no. 16; pp. 3259 - 3269
Main Authors:	Unterseher, Frank, Hefele, Joerg A, Giehl, Klaudia, De Robertis, Eddy M, Wedlich, Doris, Schambony, Alexandra
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 18-08-2004 Blackwell Publishing Ltd Nature Publishing Group
Subjects:	Animals Cadherins - genetics Cadherins - metabolism Cell Polarity convergent extension Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Enzyme Activation Freshwater Gastrula - cytology Gastrula - metabolism In Situ Hybridization Intercellular Signaling Peptides and Proteins - metabolism JNK JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism planar cell polarity rac1 GTP-Binding Protein - metabolism Rho A rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Wnt Proteins Xenopus laevis Xenopus laevis - embryology Xenopus laevis - genetics Xenopus laevis - metabolism Xenopus Proteins XPAPC
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Summary:	Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively promotes convergence in CE movements. XPAPC signals through the small GTPases Rho A and Rac 1 and c‐jun N‐terminal kinase (JNK). Loss of XPAPC function blocks Rho A‐mediated JNK activation. Despite common downstream components, XPAPC and Wnt/PCP signalling are not redundant, and the activity of both, XPAPC and PCP signalling, is required to coordinate CE movements.
Bibliography:	ark:/67375/WNG-PLWCTDRG-J ArticleID:EMBJ7600332 istex:7E3DD3A40AE51692F3985F7FE37A398B508C88DB Supplementary Figure 1Supplementary Figure 2Supplementary Figure 3Supplementary Clip 1Supplementary Figure 4Supplementary Clip 2Supplementary Figure 5Supplementary Figure 6 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work
ISSN:	0261-4189 1460-2075
DOI:	10.1038/sj.emboj.7600332