Search Results - "Heesters, Balthasar A"

Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation by Heesters, Balthasar A., Chatterjee, Priyadarshini, Kim, Young-A., Gonzalez, Santiago F., Kuligowski, Michael P., Kirchhausen, Tomas, Carroll, Michael C.

“…Stromal-derived follicular dendritic cells (FDCs) are a major reservoir for antigen that are essential for formation of germinal centers, the site where memory…”
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KLRG1 and NKp46 discriminate subpopulations of human CD117 + CRTH2 - ILCs biased toward ILC2 or ILC3 by Nagasawa, Maho, Heesters, Balthasar A, Kradolfer, Chantal M A, Krabbendam, Lisette, Martinez-Gonzalez, Itziar, de Bruijn, Marjolein J W, Golebski, Korneliusz, Hendriks, Rudi W, Stadhouders, Ralph, Spits, Hergen, Bal, Suzanne M

“…Recently, human ILCs that express CD117 and CD127 but lack CRTH2 and NKp44 have been shown to contain precursors of ILC1, ILC2, and ILC3. However, these ILCs…”
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Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses by Das, Abhishek, Heesters, Balthasar A., Bialas, Allison, O’Flynn, Joseph, Rifkin, Ian R., Ochando, Jordi, Mittereder, Nanette, Carlesso, Gianluca, Herbst, Ronald, Carroll, Michael C.

“…A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GCs) in lymphoid tissues where self-reactive B cells expand and…”
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IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation by Golebski, Korneliusz, Ros, Xavier R., Nagasawa, Maho, van Tol, Sophie, Heesters, Balthasar A., Aglmous, Hajar, Kradolfer, Chantal M. A., Shikhagaie, Medya M., Seys, Sven, Hellings, P. W., van Drunen, Cornelis M., Fokkens, Wytske J., Spits, Hergen, Bal, Suzanne M.

“…Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue…”
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The follicular dendritic cell: At the germinal center of autoimmunity? by Krimpenfort, Luc T., Degn, Søren E., Heesters, Balthasar A.

“…Autoimmune diseases strain healthcare systems worldwide as their incidence rises, and current treatments put patients at risk for infections. An increased…”
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Protocol for the isolation and purification of human follicular dendritic cells for functional assays by Breeuwsma, Martijn, Heesters, Balthasar A.

“…In this protocol, we detail how to isolate and purify human follicular dendritic cells (FDCs) from lymphoid tissues. FDCs play a vital role in antibody…”
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Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes by Heesters, Balthasar A, Lindqvist, Madelene, Vagefi, Parsia A, Scully, Eileen P, Schildberg, Frank A, Altfeld, Marcus, Walker, Bruce D, Kaufmann, Daniel E, Carroll, Michael C

“…Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound…”
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Trafficking of B cell antigen in lymph nodes by Gonzalez, Santiago F, Degn, Søren E, Pitcher, Lisa A, Woodruff, Matthew, Heesters, Balthasar A, Carroll, Michael C

“…The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology (1). At the time, it revolutionized the thinking of…”
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Loss of intestinal sympathetic innervation elicits an innate immune driven colitis by Willemze, Rose A, Welting, Olaf, van Hamersveld, Patricia, Verseijden, Caroline, Nijhuis, Laurens E, Hilbers, Francisca W, Meijer, Sybren L, Heesters, Balthasar A, Folgering, Joost H A, Darwinkel, Harold, Blancou, Philippe, Vervoordeldonk, Margriet J, Seppen, Jurgen, Heinsbroek, Sigrid E M, de Jonge, Wouter J

“…Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in…”
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The Role of Dendritic Cells in S. pneumoniae Transport to Follicular Dendritic Cells by Heesters, Balthasar A., Carroll, Michael C.

“…Affinity-mature B cells require cognate antigen, retained by follicular dendritic cells (FDCs), for clonal selection within germinal centers. Studies on how…”
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Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice by Küçükköse, Emre, Heesters, Balthasar A, Villaudy, Julien, Verheem, André, Cercel, Madalina, van Hal, Susan, Boj, Sylvia F, Borel Rinkes, Inne H M, Punt, Cornelis J A, Roodhart, Jeanine M L, Laoukili, Jamila, Koopman, Miriam, Spits, Hergen, Kranenburg, Onno

“…BackgroundThe immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune…”
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Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins by Langereis, Martijn A., Bakkers, Mark J.G., Deng, Lingquan, Padler-Karavani, Vered, Vervoort, Stephin J., Hulswit, Ruben J.G., van Vliet, Arno L.W., Gerwig, Gerrit J., de Poot, Stefanie A.H., Boot, Willemijn, van Ederen, Anne Marie, Heesters, Balthasar A., van der Loos, Chris M., van Kuppeveld, Frank J.M., Yu, Hai, Huizinga, Eric G., Chen, Xi, Varki, Ajit, Kamerling, Johannis P., de Groot, Raoul J.

“…Sialic acids (Sias), 9-carbon-backbone sugars, are among the most complex and versatile molecules of life. As terminal residues of glycans on proteins and…”
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Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases by van der Ploeg, Esmee K, Golebski, Korneliusz, van Nimwegen, Menno, Fergusson, Joannah R, Heesters, Balthasar A, Martinez-Gonzalez, Itziar, Kradolfer, Chantal M A, van Tol, Sophie, Scicluna, Brendon P, de Bruijn, Marjolein J W, de Boer, Geertje M, Tramper-Stranders, Gerdien A, Braunstahl, Gert-Jan, van IJcken, Wilfred F J, Nagtegaal, A Paul, van Drunen, Cornelis M, Fokkens, Wytske J, Huylebroeck, Danny, Spits, Hergen, Hendriks, Rudi W, Stadhouders, Ralph, Bal, Suzanne M

“…Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have been implicated in various immune disorders. In the mouse, circulatory…”
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Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens by Fergusson, Joannah R, Morgan, Michael D, Bruchard, Melanie, Huitema, Leonie, Heesters, Balthasar A, van Unen, Vincent, van Hamburg, Jan Piet, van der Wel, Nicole N, Picavet, Daisy, Koning, Frits, Tas, Sander W, Anderson, Mark S, Marioni, John C, Holländer, Georg A, Spits, Hergen

“…Expression of the Autoimmune regulator (AIRE) outside of the thymus has long been suggested in both humans and mice, but the cellular source in humans has…”
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A Meta-Analysis of the Effect of Corticosteroid Injection for Enthesopathy of the Extensor Carpi Radialis Brevis Origin by Claessen, Femke M.A.P., MD, PhD, Heesters, Balthasar A., PhD, Chan, Jimmy J., BSc, Kachooei, Amir Reza, MD, Ring, David, MD, PhD

“…Purpose The null hypothesis that there is no effect of corticosteroid injection on visual analog scale for pain in patients with enthesopathy of the extensor…”
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Follicular dendritic cells: dynamic antigen libraries by Heesters, Balthasar A., Myers, Riley C., Carroll, Michael C.

“…Key Points Follicular dendritic cells (FDCs) are non-haematopoietic cells that are of stromal origin. They are integrated into the continuous stromal network…”
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Antigen Presentation to B Cells by Heesters, Balthasar A, van der Poel, Cees E, Das, Abhishek, Carroll, Michael C

“…Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also…”
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Bacteria activate sensory neurons that modulate pain and inflammation by Chiu, Isaac M., Heesters, Balthasar A., Ghasemlou, Nader, Von Hehn, Christian A., Zhao, Fan, Tran, Johnathan, Wainger, Brian, Strominger, Amanda, Muralidharan, Sriya, Horswill, Alexander R., Wardenburg, Juliane Bubeck, Hwang, Sun Wook, Carroll, Michael C., Woolf, Clifford J.

“…Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting…”
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Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells by Heesters, Balthasar A, van Megesen, Kyah, Tomris, Ilhan, de Vries, Robert P, Magri, Giuliana, Spits, Hergen

“…Stromal-derived follicular dendritic cells (FDCs) are essential for germinal centers (GCs), the site where B cells maturate their antibodies. FDCs present…”
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Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response by Golebski, Korneliusz, Layhadi, Janice A., Sahiner, Umit, Steveling-Klein, Esther H., Lenormand, Madison M., Li, Rachael C.Y., Bal, Suzanne M., Heesters, Balthasar A., Vilà-Nadal, Gemma, Hunewald, Oliver, Montamat, Guillem, He, Feng Q., Ollert, Markus, Fedina, Oleksandra, Lao-Araya, Mongkol, Vijverberg, Susanne J.H., Maitland-van der Zee, Anke-Hilse, van Drunen, Cornelis M., Fokkens, Wytske J., Durham, Stephen R., Spits, Hergen, Shamji, Mohamed H.

“…The role of innate immune cells in allergen immunotherapy that confers immune tolerance to the sensitizing allergen is unclear. Here, we report a role of…”
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